Ifenprodil: Difference between revisions

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Ifenprodil
Names
	IUPAC name 4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
Identifiers
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL305187 ;
ChemSpider	3561 ;
DrugBank	DB08954 ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D08064 ;
PubChem CID	3689;
	InChI InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 Key: UYNVMODNBIQBMV-UHFFFAOYSA-N ; InChI=1/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3 Key: UYNVMODNBIQBMV-UHFFFAOYAU;
	SMILES OC(c1ccc(O)cc1)C(N2CCC(CC2)Cc3ccccc3)C;
Properties
Chemical formula	C21H27NO2
Molar mass	325.445
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

VisualWikitext

Revision as of 15:59, 10 April 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ifenprodil is a selective inhibitor of the NMDA receptor.^[1] Its effect is specific to receptors composed of the NR1 (glycine-binding NMDA receptor subunit 1; GluN1) and NR2B (glutamate-binding NMDA receptor subunit 2; GluN2B) subunits.^[2]

NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.

References

↑ Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758–65. PMID 2555674.
↑ Korinek M, Kapras V, Vyklicky V, Adamusova E, Borovska J, Vales K, Stuchlik A, Horak M, Chodounska H, Vyklicky L Jr (Dec 2011). "Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects". Steroids. 76 (13): 1409–18. doi:10.1016/j.steroids.2011.09.002. PMID 21925193.

Template:Peripheral vasodilators

[pmid2555674-1] Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758–65. PMID 2555674.

[2] Korinek M, Kapras V, Vyklicky V, Adamusova E, Borovska J, Vales K, Stuchlik A, Horak M, Chodounska H, Vyklicky L Jr (Dec 2011). "Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects". Steroids. 76 (13): 1409–18. doi:10.1016/j.steroids.2011.09.002. PMID 21925193.

[1]

[2]

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 ==Overview==
 '''Ifenprodil''' is a selective inhibitor of the [[NMDA receptor]].<ref name="pmid2555674">{{cite journal |author=Reynolds IJ, Miller RJ |title=Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines |journal=Mol. Pharmacol. |volume=36 |issue=5 |pages=758–65 |year=1989 |pmid=2555674 |doi=}}</ref> Its effect is specific to receptors composed of the NR1 (glycine-binding NMDA receptor subunit 1; GluN1) and NR2B (glutamate-binding NMDA receptor subunit 2; GluN2B) subunits.<ref>{{cite journal |author=Korinek M, Kapras V, Vyklicky V, Adamusova E, Borovska J, Vales K, Stuchlik A, Horak M, Chodounska H, Vyklicky L Jr |title=Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects |journal=Steroids |volume=76 |issue=13 |pages=1409–18 |date=Dec 2011 |pmid=   21925193 |doi=10.1016/j.steroids.2011.09.002 }}</ref>
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-{{Glutamate_receptor_ligands}}
 {{Peripheral vasodilators}}

Ifenprodil: Difference between revisions

Revision as of 15:59, 10 April 2015

Overview

References

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