ITGB7: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Integrin beta-7''' is an [[integrin]] [[protein]] that in humans is encoded by the ''ITGB7'' [[gene]].<ref name="pmid2040616">{{cite journal | vauthors = Erle DJ, Rüegg C, Sheppard D, Pytela R | title = Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes | journal = The Journal of Biological Chemistry | volume = 266 | issue = 17 | pages = 11009–16 | date = Jun 1991 | pmid = 2040616 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITGB7 integrin, beta 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3695| accessdate = }}</ref> It can pair with [[ITGA4]] (CD49d) to form the [[heterodimer|heterodimeric]] integrin [[Receptor (biochemistry)|receptor]] α{{sub|4}}β{{sub|7}}, or with [[ITGAE]] (CD103) to form α{{sub|E}}β{{sub|7}}.<ref name="pmid19910492">{{cite journal | vauthors = Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ | title = Anti-integrin monoclonal antibodies | journal = Journal of Cell Science | volume = 122 | issue = Pt 22 | pages = 4009–11 | date = Nov 2009 | pmid = 19910492 | pmc = 3329622 | doi = 10.1242/jcs.056770 }} </ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Structure ==
{{GNF_Protein_box
| image = PBB_Protein_ITGB7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2brq.
| PDB = {{PDB2|2brq}}
| Name = Integrin, beta 7
| HGNCid = 6162
| Symbol = ITGB7
| AltSymbols =;
| OMIM = 147559
| ECnumber = 
| Homologene = 20247
| MGIid = 96616
| GeneAtlas_image1 = PBB_GE_ITGB7_205718_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3695
    | Hs_Ensembl = ENSG00000139626
    | Hs_RefseqProtein = NP_000880
    | Hs_RefseqmRNA = NM_000889
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 51871375
    | Hs_GenLoc_end = 51887267
    | Hs_Uniprot = P26010
    | Mm_EntrezGene = 16421
    | Mm_Ensembl = ENSMUSG00000001281
    | Mm_RefseqmRNA = NM_013566
    | Mm_RefseqProtein = NP_038594
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 102044030
    | Mm_GenLoc_end = 102059969
    | Mm_Uniprot = P26011
  }}
}}
'''Integrin, beta 7''', also known as '''ITGB7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ITGB7 integrin, beta 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3695| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Like all integrin subunits, β{{sub|7}} is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for [[ligand (biochemistry)|ligand]] through conformational changes.<ref name="pmid14519389">{{cite journal | vauthors = Carman CV, Springer TA | title = Integrin avidity regulation: are changes in affinity and conformation underemphasized? | journal = Current Opinion in Cell Biology | volume = 15 | issue = 5 | pages = 547–56 | date = Oct 2003 | pmid = 14519389 | doi = 10.1016/j.ceb.2003.08.003 }}</ref> Beginning with the apical end of the protein, farthest from the cell membrane, the β{{sub|7}} is composed of a head and upper legs, collectively known as the headpiece, lower legs, a [[transmembrane domain]] and a [[cytoplasmic]] tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is [[N-terminal]] to the I-like domain.  Below the hybrid domain is the PSI domain, which completes the headpiece.  The lower legs consist of [[EGF domain]]s 1-4 and the β tail domain. Finally there is a transmembrane domain, and the [[C-terminal]] cytoplasmic tail.<ref name="pmid22232704">{{cite journal | vauthors = Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA | title = Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion | journal = The Journal of Cell Biology | volume = 196 | issue = 1 | pages = 131–46 | date = Jan 2012 | pmid = 22232704 | pmc = 3255974 | doi = 10.1083/jcb.201110023 }}</ref>
{{PBB_Summary
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}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ITGB7 has been shown to [[Protein-protein_interaction|interact]] with [[EED (protein)|EED]].<ref name="pmid9765275">{{cite journal | vauthors = Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B | title = The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27459–66 | date = Oct 1998 | pmid = 9765275 | doi = 10.1074/jbc.273.42.27459 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ | title = Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering | journal = The Journal of Cell Biology | volume = 117 | issue = 1 | pages = 179–89 | date = Apr 1992 | pmid = 1372909 | pmc = 2289398 | doi = 10.1083/jcb.117.1.179 }}
| citations =
* {{cite journal | vauthors = Chan BM, Elices MJ, Murphy E, Hemler ME | title = Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY | journal = The Journal of Biological Chemistry | volume = 267 | issue = 12 | pages = 8366–70 | date = Apr 1992 | pmid = 1373725 | doi =  }}
*{{cite journal | author=Rüegg C, Postigo AA, Sikorski EE, ''et al.'' |title=Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering. |journal=J. Cell Biol. |volume=117 |issue= 1 |pages= 179-89 |year= 1992 |pmid= 1372909 |doi= }}
* {{cite journal | vauthors = Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD, Krissansen GW | title = The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1 | journal = International Immunology | volume = 4 | issue = 9 | pages = 1031–40 | date = Sep 1992 | pmid = 1382574 | doi = 10.1093/intimm/4.9.1031 }}
*{{cite journal | author=Chan BM, Elices MJ, Murphy E, Hemler ME |title=Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8366-70 |year= 1992 |pmid= 1373725 |doi=  }}
* {{cite journal | vauthors = Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD, Krissansen GW | title = Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization | journal = Mammalian Genome | volume = 2 | issue = 4 | pages = 272–3 | year = 1992 | pmid = 1543919 | doi = 10.1007/BF00355438 }}
*{{cite journal | author=Jiang WM, Jenkins D, Yuan Q, ''et al.'' |title=The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1. |journal=Int. Immunol. |volume=4 |issue= 9 |pages= 1031-40 |year= 1992 |pmid= 1382574 |doi= }}
* {{cite journal | vauthors = Yuan QA, Jiang WM, Krissansen GW, Watson JD | title = Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains | journal = International Immunology | volume = 3 | issue = 12 | pages = 1373–4 | date = Dec 1991 | pmid = 1777426 | doi = 10.1093/intimm/3.12.1373 }}
*{{cite journal | author=Baker E, Sutherland GR, Jiang WM, ''et al.'' |title=Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization. |journal=Mamm. Genome |volume=2 |issue= 4 |pages= 272-3 |year= 1992 |pmid= 1543919 |doi= }}
* {{cite journal | vauthors = Yuan QA, Jiang WM, Krissansen GW, Watson JD | title = Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains | journal = International Immunology | volume = 2 | issue = 11 | pages = 1097–108 | year = 1991 | pmid = 2083230 | doi = 10.1093/intimm/2.11.1097 }}
*{{cite journal | author=Yuan QA, Jiang WM, Krissansen GW, Watson JD |title=Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. |journal=Int. Immunol. |volume=3 |issue= 12 |pages= 1373-4 |year= 1992 |pmid= 1777426 |doi= }}
* {{cite journal | vauthors = Erle DJ, Brown T, Christian D, Aris R | title = Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression | journal = American Journal of Respiratory Cell and Molecular Biology | volume = 10 | issue = 3 | pages = 237–44 | date = Mar 1994 | pmid = 7509610 | doi = 10.1165/ajrcmb.10.3.7509610 }}
*{{cite journal | author=Erle DJ, Rüegg C, Sheppard D, Pytela R |title=Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11009-16 |year= 1991 |pmid= 2040616 |doi= }}
* {{cite journal | vauthors = Postigo AA, Sánchez-Mateos P, Lazarovits AI, Sánchez-Madrid F, de Landázuri MO | title = Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes | journal = Journal of Immunology | volume = 151 | issue = 5 | pages = 2471–83 | date = Sep 1993 | pmid = 7689608 | doi =  }}
*{{cite journal | author=Yuan QA, Jiang WM, Krissansen GW, Watson JD |title=Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains. |journal=Int. Immunol. |volume=2 |issue= 11 |pages= 1097-108 |year= 1991 |pmid= 2083230 |doi= }}
* {{cite journal | vauthors = Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM | title = Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution | journal = The Journal of Biological Chemistry | volume = 269 | issue = 8 | pages = 6016–25 | date = Feb 1994 | pmid = 8119947 | doi =  }}
*{{cite journal | author=Erle DJ, Brown T, Christian D, Aris R |title=Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression. |journal=Am. J. Respir. Cell Mol. Biol. |volume=10 |issue= 3 |pages= 237-44 |year= 1994 |pmid= 7509610 |doi=  }}
* {{cite journal | vauthors = Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ | title = Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1 | journal = Journal of Immunology | volume = 159 | issue = 3 | pages = 1497–505 | date = Aug 1997 | pmid = 9233649 | doi =  }}
*{{cite journal | author=Postigo AA, Sánchez-Mateos P, Lazarovits AI, ''et al.'' |title=Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes. |journal=J. Immunol. |volume=151 |issue= 5 |pages= 2471-83 |year= 1993 |pmid= 7689608 |doi=  }}
* {{cite journal | vauthors = Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH | title = The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition | journal = Structure | volume = 6 | issue = 6 | pages = 793–801 | date = Jun 1998 | pmid = 9655832 | doi = 10.1016/S0969-2126(98)00080-X }}
*{{cite journal | author=Shaw SK, Cepek KL, Murphy EA, ''et al.'' |title=Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution. |journal=J. Biol. Chem. |volume=269 |issue= 8 |pages= 6016-25 |year= 1994 |pmid= 8119947 |doi=  }}
* {{cite journal | vauthors = Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B | title = The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27459–66 | date = Oct 1998 | pmid = 9765275 | doi = 10.1074/jbc.273.42.27459 }}
*{{cite journal | author=Tidswell M, Pachynski R, Wu SW, ''et al.'' |title=Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1. |journal=J. Immunol. |volume=159 |issue= 3 |pages= 1497-505 |year= 1997 |pmid= 9233649 |doi= }}
* {{cite journal | vauthors = Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB | title = Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin | journal = The Journal of Experimental Medicine | volume = 191 | issue = 9 | pages = 1555–67 | date = May 2000 | pmid = 10790430 | pmc = 2213439 | doi = 10.1084/jem.191.9.1555 }}
*{{cite journal | author=Tan K, Casasnovas JM, Liu JH, ''et al.'' |title=The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. |journal=Structure |volume=6 |issue= 6 |pages= 793-801 |year= 1998 |pmid= 9655832 |doi= }}
* {{cite journal | vauthors = Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB | title = The role of alpha and beta chains in ligand recognition by beta 7 integrins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 33 | pages = 25652–64 | date = Aug 2000 | pmid = 10837471 | doi = 10.1074/jbc.M001228200 }}
*{{cite journal | author=Rietzler M, Bittner M, Kolanus W, ''et al.'' |title=The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27459-66 |year= 1998 |pmid= 9765275 |doi= }}
* {{cite journal | vauthors = Puig-Kröger A, Sanz-Rodríguez F, Longo N, Sánchez-Mateos P, Botella L, Teixidó J, Bernabéu C, Corbí AL | title = Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells | journal = Journal of Immunology | volume = 165 | issue = 8 | pages = 4338–45 | date = Oct 2000 | pmid = 11035069 | doi = 10.4049/jimmunol.165.8.4338 }}
*{{cite journal | author=Taraszka KS, Higgins JM, Tan K, ''et al.'' |title=Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin. |journal=J. Exp. Med. |volume=191 |issue= 9 |pages= 1555-67 |year= 2000 |pmid= 10790430 |doi= }}
* {{cite journal | vauthors = Guilliano MJ, Foxx-Orenstein AE, Lebman DA | title = The microenvironment of human Peyer's patches inhibits the increase in CD38 expression associated with the germinal center reaction | journal = Journal of Immunology | volume = 166 | issue = 4 | pages = 2179–85 | date = Feb 2001 | pmid = 11160270 | doi = 10.4049/jimmunol.166.4.2179 }}
*{{cite journal | author=Higgins JM, Cernadas M, Tan K, ''et al.'' |title=The role of alpha and beta chains in ligand recognition by beta 7 integrins. |journal=J. Biol. Chem. |volume=275 |issue= 33 |pages= 25652-64 |year= 2000 |pmid= 10837471 |doi= 10.1074/jbc.M001228200 }}
* {{cite journal | vauthors = Calderwood DA, Huttenlocher A, Kiosses WB, Rose DM, Woodside DG, Schwartz MA, Ginsberg MH | title = Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration | journal = Nature Cell Biology | volume = 3 | issue = 12 | pages = 1060–8 | date = Dec 2001 | pmid = 11781567 | doi = 10.1038/ncb1201-1060 }}
*{{cite journal | author=Puig-Kröger A, Sanz-Rodríguez F, Longo N, ''et al.'' |title=Maturation-dependent expression and function of the CD49d integrin on monocyte-derived human dendritic cells. |journal=J. Immunol. |volume=165 |issue= 8 |pages= 4338-45 |year= 2000 |pmid= 11035069 |doi= }}
* {{cite journal | vauthors = Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH | title = Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 5 | pages = 2272–7 | date = Mar 2003 | pmid = 12606711 | pmc = 151330 | doi = 10.1073/pnas.262791999 }}
*{{cite journal | author=Guilliano MJ, Foxx-Orenstein AE, Lebman DA |title=The microenvironment of human Peyer's patches inhibits the increase in CD38 expression associated with the germinal center reaction. |journal=J. Immunol. |volume=166 |issue= 4 |pages= 2179-85 |year= 2001 |pmid= 11160270 |doi= }}
*{{cite journal | author=Calderwood DA, Huttenlocher A, Kiosses WB, ''et al.'' |title=Increased filamin binding to beta-integrin cytoplasmic domains inhibits cell migration. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1060-8 |year= 2002 |pmid= 11781567 |doi= 10.1038/ncb1201-1060 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Calderwood DA, Fujioka Y, de Pereda JM, ''et al.'' |title=Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2272-7 |year= 2003 |pmid= 12606711 |doi= 10.1073/pnas.262791999 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&orth_acc=co00001489 ITGB7] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
 
{{PDB Gallery|geneid=3695}}
{{Integrins}}

Latest revision as of 01:50, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Integrin beta-7 is an integrin protein that in humans is encoded by the ITGB7 gene.[1][2] It can pair with ITGA4 (CD49d) to form the heterodimeric integrin receptor α4β7, or with ITGAE (CD103) to form αEβ7.[3]

Structure

Like all integrin subunits, β7 is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes.[4] Beginning with the apical end of the protein, farthest from the cell membrane, the β7 is composed of a head and upper legs, collectively known as the headpiece, lower legs, a transmembrane domain and a cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the C-terminal cytoplasmic tail.[5]

Interactions

ITGB7 has been shown to interact with EED.[6]

References

  1. ↑ Erle DJ, Rüegg C, Sheppard D, Pytela R (Jun 1991). "Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes". The Journal of Biological Chemistry. 266 (17): 11009–16. PMID 2040616.
  2. ↑ "Entrez Gene: ITGB7 integrin, beta 7".
  3. ↑ Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ (Nov 2009). "Anti-integrin monoclonal antibodies". Journal of Cell Science. 122 (Pt 22): 4009–11. doi:10.1242/jcs.056770. PMC 3329622. PMID 19910492.
  4. ↑ Carman CV, Springer TA (Oct 2003). "Integrin avidity regulation: are changes in affinity and conformation underemphasized?". Current Opinion in Cell Biology. 15 (5): 547–56. doi:10.1016/j.ceb.2003.08.003. PMID 14519389.
  5. ↑ Yu Y, Zhu J, Mi LZ, Walz T, Sun H, Chen J, Springer TA (Jan 2012). "Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion". The Journal of Cell Biology. 196 (1): 131–46. doi:10.1083/jcb.201110023. PMC 3255974. PMID 22232704.
  6. ↑ Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B (Oct 1998). "The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins". The Journal of Biological Chemistry. 273 (42): 27459–66. doi:10.1074/jbc.273.42.27459. PMID 9765275.

Further reading

  • Rüegg C, Postigo AA, Sikorski EE, Butcher EC, Pytela R, Erle DJ (Apr 1992). "Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte adherence to fibronectin and VCAM-1 and in homotypic cell clustering". The Journal of Cell Biology. 117 (1): 179–89. doi:10.1083/jcb.117.1.179. PMC 2289398. PMID 1372909.
  • Chan BM, Elices MJ, Murphy E, Hemler ME (Apr 1992). "Adhesion to vascular cell adhesion molecule 1 and fibronectin. Comparison of alpha 4 beta 1 (VLA-4) and alpha 4 beta 7 on the human B cell line JY". The Journal of Biological Chemistry. 267 (12): 8366–70. PMID 1373725.
  • Jiang WM, Jenkins D, Yuan Q, Leung E, Choo KH, Watson JD, Krissansen GW (Sep 1992). "The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1". International Immunology. 4 (9): 1031–40. doi:10.1093/intimm/4.9.1031. PMID 1382574.
  • Baker E, Sutherland GR, Jiang WM, Yuan Q, Leung E, Watson JD, Krissansen GW (1992). "Mapping of the human integrin beta 7 gene (ITG beta 7) to 12q13.13 by non-isotopic in situ hybridization". Mammalian Genome. 2 (4): 272–3. doi:10.1007/BF00355438. PMID 1543919.
  • Yuan QA, Jiang WM, Krissansen GW, Watson JD (Dec 1991). "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains". International Immunology. 3 (12): 1373–4. doi:10.1093/intimm/3.12.1373. PMID 1777426.
  • Yuan QA, Jiang WM, Krissansen GW, Watson JD (1991). "Cloning and sequence analysis of a novel beta 2-related integrin transcript from T lymphocytes: homology of integrin cysteine-rich repeats to domain III of laminin B chains". International Immunology. 2 (11): 1097–108. doi:10.1093/intimm/2.11.1097. PMID 2083230.
  • Erle DJ, Brown T, Christian D, Aris R (Mar 1994). "Lung epithelial lining fluid T cell subsets defined by distinct patterns of beta 7 and beta 1 integrin expression". American Journal of Respiratory Cell and Molecular Biology. 10 (3): 237–44. doi:10.1165/ajrcmb.10.3.7509610. PMID 7509610.
  • Postigo AA, Sánchez-Mateos P, Lazarovits AI, Sánchez-Madrid F, de Landázuri MO (Sep 1993). "Alpha 4 beta 7 integrin mediates B cell binding to fibronectin and vascular cell adhesion molecule-1. Expression and function of alpha 4 integrins on human B lymphocytes". Journal of Immunology. 151 (5): 2471–83. PMID 7689608.
  • Shaw SK, Cepek KL, Murphy EA, Russell GJ, Brenner MB, Parker CM (Feb 1994). "Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution". The Journal of Biological Chemistry. 269 (8): 6016–25. PMID 8119947.
  • Tidswell M, Pachynski R, Wu SW, Qiu SQ, Dunham E, Cochran N, Briskin MJ, Kilshaw PJ, Lazarovits AI, Andrew DP, Butcher EC, Yednock TA, Erle DJ (Aug 1997). "Structure-function analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1". Journal of Immunology. 159 (3): 1497–505. PMID 9233649.
  • Tan K, Casasnovas JM, Liu JH, Briskin MJ, Springer TA, Wang JH (Jun 1998). "The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition". Structure. 6 (6): 793–801. doi:10.1016/S0969-2126(98)00080-X. PMID 9655832.
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External links

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