IL17A
| Interleukin 17A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | IL17A ; CTLA8; IL-17; IL-17A; IL17 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1651 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
 | |||||||||||
 | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Interleukin 17A, also known as IL17A, is a human gene.[1]
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.[1]
See also
References
Further reading
- Gaffen SL (2005). "Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis". Arthritis Res. Ther. 6 (6): 240–7. doi:10.1186/ar1444. PMID 15535837.
- Lubberts E, Koenders MI, van den Berg WB (2006). "The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models". Arthritis Res. Ther. 7 (1): 29–37. doi:10.1186/ar1478. PMID 15642151.
- Yao Z, Painter SL, Fanslow WC; et al. (1996). "Human IL-17: a novel cytokine derived from T cells". J. Immunol. 155 (12): 5483–6. PMID 7499828.
- Rouvier E, Luciani MF, Mattéi MG; et al. (1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". J. Immunol. 150 (12): 5445–56. PMID 8390535.
- Fossiez F, Djossou O, Chomarat P; et al. (1996). "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines". J. Exp. Med. 183 (6): 2593–603. PMID 8676080.
- Yao Z, Spriggs MK, Derry JM; et al. (1998). "Molecular characterization of the human interleukin (IL)-17 receptor". Cytokine. 9 (11): 794–800. PMID 9367539.
- Murphy KP, Gagne P, Pazmany C, Moody MD (1998). "Expression of human interleukin-17 in Pichia pastoris: purification and characterization". Protein Expr. Purif. 12 (2): 208–14. doi:10.1006/prep.1997.0832. PMID 9518462.
- Teunissen MB, Koomen CW, de Waal Malefyt R; et al. (1998). "Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes". J. Invest. Dermatol. 111 (4): 645–9. doi:10.1046/j.1523-1747.1998.00347.x. PMID 9764847.
- Shalom-Barak T, Quach J, Lotz M (1998). "Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappaB". J. Biol. Chem. 273 (42): 27467–73. PMID 9765276.
- Shin HC, Benbernou N, Fekkar H; et al. (1999). "Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway". Cytokine. 10 (11): 841–50. doi:10.1006/cyto.1998.0375. PMID 9878122.
- Laan M, Cui ZH, Hoshino H; et al. (1999). "Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways". J. Immunol. 162 (4): 2347–52. PMID 9973514.
- Kotake S, Udagawa N, Takahashi N; et al. (1999). "IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis". J. Clin. Invest. 103 (9): 1345–52. PMID 10225978.
- Shin HC, Benbernou N, Esnault S, Guenounou M (1999). "Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway". Cytokine. 11 (4): 257–66. doi:10.1006/cyto.1998.0433. PMID 10328864.
- Andoh A, Takaya H, Makino J; et al. (2001). "Cooperation of interleukin-17 and interferon-gamma on chemokine secretion in human fetal intestinal epithelial cells". Clin. Exp. Immunol. 125 (1): 56–63. PMID 11472426.
- Laan M, Palmberg L, Larsson K, Lindén A (2002). "Free, soluble interleukin-17 protein during severe inflammation in human airways". Eur. Respir. J. 19 (3): 534–7. PMID 11936535.
- Andoh A, Fujino S, Bamba S; et al. (2002). "IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts". J. Immunol. 169 (4): 1683–7. PMID 12165487.
- Andoh A, Shimada M, Bamba S; et al. (2002). "Extracellular signal-regulated kinases 1 and 2 participate in interleukin-17 plus tumor necrosis factor-alpha-induced stabilization of interleukin-6 mRNA in human pancreatic myofibroblasts". Biochim. Biophys. Acta. 1591 (1–3): 69–74. PMID 12183057.
- Hsieh HG, Loong CC, Lin CY (2003). "Interleukin-17 induces src/MAPK cascades activation in human renal epithelial cells". Cytokine. 19 (4): 159–74. PMID 12297109.
- Aggarwal S, Ghilardi N, Xie MH; et al. (2003). "Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17". J. Biol. Chem. 278 (3): 1910–4. doi:10.1074/jbc.M207577200. PMID 12417590.
- Maertzdorf J, Osterhaus AD, Verjans GM (2003). "IL-17 expression in human herpetic stromal keratitis: modulatory effects on chemokine production by corneal fibroblasts". J. Immunol. 169 (10): 5897–903. PMID 12421973.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.