Hyperparathyroidism laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Laboratory Findings

Serum Calcium

In cases of primary, tertiary and quintary hyperparathyroidism increased PTH consequently leads to increased serum calcium (hypercalcemia) due to:

1. increased bone resorption, allowing flow of calcium from bone to blood
2. reduced renal clearance of calcium
3. increased intestinal calcium absorption

By contrast, in secondary and quartary hyperparathyroidism effectiveness of PTHis reduced.

Serum Phosphorus

In primary hyperparathyroidism, serum phosphorus levels are abnormally low as a result of decreased renal tubular phosphorus reabsorption. This contrasts with secondary hyperparathyroidism, in which serum phosphorus levels are generally elevated because of renal disease.

Alkaline Phosphatase

Alkaline phosphatase levels are elevated in all types of hyperparathyroidism.