Hypercalcemia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Causes

Common Causes

Primary hyperparathyroidism is the most common cause of hypercalcemia. It is due to excess PTH release by the parathyroid glands. This excess occurs due to an enlargement of one or more of the parathyroid glands, or a growth (usually not cancer) on one of the glands.

Other common causes include:

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning Aluminum intoxication, Hypervitaminosis D, Vitamin A intoxication, Vitamin D intoxication
Dermatologic Leprosy
Drug Side Effect caspofungin acetate, Dexlansoprazole, Lithium, Nandrolone, Tamoxifen, Thiazide diuretics
Ear Nose Throat Oral candidiasis
Endocrine Abnormal parathyroid gland function, Acromegaly, Acute osteoporosis, Addison's Disease, Adrenal insufficiency, Autonomous hyperparathyroidism (post long-term renal failure), Bartter's Syndrome, Cushing's syndrome, Familial isolated hyperparathyroidism, Hyperparathyroidism (in the preceding oliguric-anuric phase), Hyperthyroidism, Isolated or multinodal adenoma, Multiple endocrine neoplasia (MEN), Parathyroid carcinoma, Parathyroid hyperplasia, Pheochromocytoma, Primary hyperparathyroidism, Primary Parathyroid hyperplasia, Secretion of prostaglandins, Severe secondary hyperparathyroidism, Solitary parathyroid adenoma, Vasoactive intestinal polypeptide-producing tumor (VIPoma)
Environmental No underlying causes
Gastroenterologic Hepatocellular carcinoma, Hypervitaminosis D, Oral candidiasis, Total parenteral nutrition
Genetic Familial hypocalcuric hypercalcemia, Familial isolated hyperparathyroidism, Gitelman syndrome, William's syndrome
Hematologic Hodgkin's lymphoma, Leukemia, Lymphoma, Multiple myeloma, Plasma cell granuloma, Polycythemia
Iatrogenic No underlying causes
Infectious Disease Coccidioidomycosis, Leprosy, Oral candidiasis
Musculoskeletal / Ortho Acute osteoporosis, Bone fracture, Paget's Disease, Rebound hypercalcemia after rhabdomyolysis
Neurologic No underlying causes
Nutritional / Metabolic Dehydration, Milk-alkali syndrome, Osteomalacia, Total parenteral nutrition, Vitamin A intoxication, Vitamin D intoxication, Vitamin D metabolic disorders
Obstetric/Gynecologic Breast cancer, Ovarian cancer, Paget's Disease
Oncologic Breast cancer, Bronchial carcinoma, Carcinoma, Hematologic malignancy (multiple myeloma, lymphoma, leukemia), Hepatocellular carcinoma, Hodgkin's lymphoma, Isolated or multinodal adenoma, Kidney cancer, Leukemia, Lymphoma, Malignancy, Multiple endocrine neoplasia (MEN), Multiple Myeloma, Ovarian cancer, Paget's Disease, Parathyroid carcinoma, Pheochromocytoma, Plasma cell granuloma, Silicone-Induced granuloma, Solid tumor with humoral mediation of hypercalcemia (e.g. lung or kidney cancer, pheochromocytoma), Solid tumor with metastasis (e.g. breast cancer), Solitary parathyroid adenoma, Vasoactive intestinal polypeptide-producing tumor (VIPoma)
Ophthalmologic No underlying causes
Overdose / Toxicity , Aluminum intoxication, Aspirin (in large amounts), Drugs, Hypervitaminosis D, Vitamin A intoxication, Vitamin D intoxication
Psychiatric No underlying causes
Pulmonary Berylliosis, Bronchial carcinoma, Granulomatous diseases with tuberculosis, Histoplasmosis, Sarcoidosis, Tuberculosis, Tuberculosis
Renal / Electrolyte Acute renal failure, After kidney transplant, Bartter's Syndrome, Chronic renal failure, Familial hypocalcuric hypercalcemia, Kidney cancer, Medullary sponge kidney, Milk-alkali syndrome, Rebound hypercalcemia after rhabdomyolysis, Renal failure
Rheum / Immune / Allergy Acute osteoporosis, Sarcoidosis, Sjogren's syndrome
Sexual No underlying causes
Trauma No underlying causes
Urologic Acute renal failure, Chronic renal failure, Milk-alkali syndrome, Renal failure
Miscellaneous Idiopathic hypercalcemia (in infants), Immobilization, Paraplegia