Hyperandrogenism

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Many patients with hyperandrogenism have one of three syndromes:

• Polycystic Ovary Syndrome
• Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
• Congenital adrenal hyperplasia due to 3 beta-hydroxysteroid dehydrogenase deficiency

History and Symptoms

General appearance

1. Muscular male body habitus (e.g. shoulder girdle)
2. Android Obesity

Miscellaneous Changes

1. Deepening of voice
2. Clitorimegaly
3. Increased Libido

Menstrual irregularity

1. Amenorrhea
2. Infertility

Endocrine changes

1. Hypertension
2. Hyperlipidemia
3. Glucose Intolerance

Skin changes

1. Hirsutism involving face, chin, chest and perineum
2. Alopecia
   1. Vertex or crown Hair Loss
   2. Bitemporal Hair Loss may also occur
3. Acanthosis Nigricans (HAIR-AN Syndrome)
4. Oily skin
5. Acne Vulgaris
6. Male sweat changes (malodorous perspiration)