Hereditary nonpolyposis colorectal cancer overview: Difference between revisions
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==[[Hereditary nonpolyposis colorectal cancer overview|Overview]]== | ==[[Hereditary nonpolyposis colorectal cancer overview|Overview]]== | ||
'''Hereditary nonpolyposis colorectal cancer''' ''(HNPCC)'' is characterized by an increased risk of [[colorectal cancer]] and other cancers of the [[Endometrial cancer|endometrium]], [[Ovarian cancer|ovary]], [[Stomach cancer|stomach]], [[Gastrointestinal cancer|small intestine]], [[Gallbladder cancer|hepatobiliary tract]], upper urinary tract, [[Brain tumor|brain]], and [[Skin cancer|skin]]. HNPCC is subdivided into Lynch Syndrome I (familial colon cancer) and Lynch Syndrome II (other cancer of the gastrointestinal system or the reproductive system). The increased risk for these cancers is due to inherited mutations that degrade the self-repair capability of [[DNA]].In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. The Amsterdam clinical criteria identifies candidates for genetic testing, and genetic testing can make a diagnosis of HPNCC. Surgery remains the mainstay therapy for HNPCC.<ref>Hereditary nonpolyposis colorectal cancer.Wikipedia.https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015</ref> | '''Hereditary nonpolyposis colorectal cancer''' ''(HNPCC)'' is characterized by an increased risk of [[colorectal cancer]] and other cancers of the [[Endometrial cancer|endometrium]], [[Ovarian cancer|ovary]], [[Stomach cancer|stomach]], [[Gastrointestinal cancer|small intestine]], [[Gallbladder cancer|hepatobiliary tract]], upper urinary tract, [[Brain tumor|brain]], and [[Skin cancer|skin]]. HNPCC is subdivided into Lynch Syndrome I (familial colon cancer) and Lynch Syndrome II (other cancer of the gastrointestinal system or the reproductive system). The increased risk for these cancers is due to inherited mutations that degrade the self-repair capability of [[DNA]]. In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. The Amsterdam clinical criteria identifies candidates for genetic testing, and genetic testing can make a diagnosis of HPNCC. Surgery remains the mainstay therapy for HNPCC.<ref>Hereditary nonpolyposis colorectal cancer.Wikipedia.https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015</ref> | ||
==[[Hereditary nonpolyposis colorectal cancer historical perspective|Historical Perspective]]== | ==[[Hereditary nonpolyposis colorectal cancer historical perspective|Historical Perspective]]== | ||
Revision as of 19:42, 1 December 2015
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Hereditary Nonpolyposis Colorectal Cancer Microchapters |
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Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Hereditary nonpolyposis colorectal cancer overview On the Web |
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American Roentgen Ray Society Images of Hereditary nonpolyposis colorectal cancer overview |
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Hereditary nonpolyposis colorectal cancer overview in the news |
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Directions to Hospitals Treating Hereditary nonpolyposis colorectal cancer |
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Risk calculators and risk factors for Hereditary nonpolyposis colorectal cancer overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
Hereditary nonpolyposis colorectal cancer (HNPCC) is characterized by an increased risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. HNPCC is subdivided into Lynch Syndrome I (familial colon cancer) and Lynch Syndrome II (other cancer of the gastrointestinal system or the reproductive system). The increased risk for these cancers is due to inherited mutations that degrade the self-repair capability of DNA. In the United States, about 160,000 new cases of colorectal cancer are diagnosed each year. The Amsterdam clinical criteria identifies candidates for genetic testing, and genetic testing can make a diagnosis of HPNCC. Surgery remains the mainstay therapy for HNPCC.[1]
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Hereditary nonpolyposis colorectal cancer from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
Staging | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | Chest X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
See also
References
- ↑ Hereditary nonpolyposis colorectal cancer.Wikipedia.https://en.wikipedia.org/wiki/Hereditary_nonpolyposis_colorectal_cancer Accessed on December 01, 2015