Hereditary nonpolyposis colorectal cancer overview: Difference between revisions
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Revision as of 00:20, 24 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Hereditary nonpolyposis colorectal cancer is characterized by an increased risk of colorectal cancer and other cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. HNPCC is subdivided into Lynch Syndrome I (familial colon cancer) and Lynch Syndrome II (other cancer of the gastrointestinal system or the reproductive system). The increased risk for these cancers is due to inherited mutations that degrade the self-repair capability of DNA.
Lynch syndrome was named in honor of Dr. Henry T. Lynch, professor of medicine at Creighton University Medical Center.[1]