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==Overview==
==Overview==
According to the [[American College of Gastroenterology Guidelines|American College of Gastroenterology]], [[Patient|patients]] with hereditary nonpolyposis colorectal cancer should undergo [[colonoscopy]] every 2 years beginning at age 20 - 25 years, until the age of 40, followed by an annual [[colonoscopy]]. [[Diagnosis|Diagnostic]] and [[Screening (medicine)|screening]] [[endoscopy]] is recommended in the case of hereditary nonpolyposis colorectal cancer.
==Other Diagnostic Studies==
[[Diagnosis|Diagnostic]] and [[Screening (medicine)|screening]] [[colonoscopy]] is recommended in the case of hereditary nonpolyposis colorectal cancer. In addition, annual upper [[endoscopy]] is highly suggested in [[Family|families]] with [[Stomach cancer|gastric cancer]].<ref name="hpcc">Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (hereditary nonpolyposis colorectal cancer , Lynch syndrome) proposed by the International Collaborative group on hereditary nonpolyposis colorectal cancer . Gastroenterology. 1999;116(6):1453-6.</ref>
===Colonoscopy===
*[[Patient|Patients]] with hereditary nonpolyposis colorectal cancer should undergo [[Diagnosis|diagnostic]] [[colonoscopy]] every 2 years beginning at age 20 - 25 years, until the age of 40, followed by an annual [[colonoscopy]].<ref name="AGG">Rex DK, Johnson DA, Lieberman DA et al. Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. Am J Gastroenterol 2000;95:868–77.</ref>
===Genetic Testing===
*The Amsterdam clinical criteria identifies candidates for [[genetic testing]], and [[genetic testing]] can make a diagnosis of Lynch syndrome.
*[[Genetic testing]] is commercially available through [[Myriad Genetics]], and consists of a [[blood test]].<ref name="hpcc">Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (hereditary nonpolyposis colorectal cancer , Lynch syndrome) proposed by the International Collaborative group on hereditary nonpolyposis colorectal cancer. Gastroenterology. 1999;116(6):1453-6.</ref>
===ACG Guidelines - Colorectal Cancer Screening===
*''[[Patient|Patients]] with positive [[Test|tests]] can be offered [[genetic testing]] and when [[genetic testing]] is positive in a [[proband]], at risk [[family]] members can be offered [[genetic testing]]. Those [[Patient|patients]] with positive [[genetic testing]], or those at risk when [[genetic testing]] is unsuccessful in an affected [[proband]], should undergo [[colonoscopy]] every 2 years beginning at age 20 - 25 years, until age 40 years, then annually thereafter (Grade 2 B).''<ref name="AGG">Rex DK, Johnson DA, Lieberman DA et al. Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. Am J Gastroenterol 2000;95:868–77.</ref>


==References==
==References==
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Latest revision as of 21:41, 29 April 2019

Hereditary Nonpolyposis Colorectal Cancer Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]

Overview

According to the American College of Gastroenterology, patients with hereditary nonpolyposis colorectal cancer should undergo colonoscopy every 2 years beginning at age 20 - 25 years, until the age of 40, followed by an annual colonoscopy. Diagnostic and screening endoscopy is recommended in the case of hereditary nonpolyposis colorectal cancer.

Other Diagnostic Studies

Diagnostic and screening colonoscopy is recommended in the case of hereditary nonpolyposis colorectal cancer. In addition, annual upper endoscopy is highly suggested in families with gastric cancer.[1]

Colonoscopy

Genetic Testing

ACG Guidelines - Colorectal Cancer Screening

References

  1. 1.0 1.1 Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (hereditary nonpolyposis colorectal cancer , Lynch syndrome) proposed by the International Collaborative group on hereditary nonpolyposis colorectal cancer . Gastroenterology. 1999;116(6):1453-6.
  2. 2.0 2.1 Rex DK, Johnson DA, Lieberman DA et al. Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. Am J Gastroenterol 2000;95:868–77.


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