Hereditary nonpolyposis colorectal cancer history and symptoms
Hereditary Nonpolyposis Colorectal Cancer Microchapters |
Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases |
---|
Diagnosis |
Treatment |
Case Studies |
Hereditary nonpolyposis colorectal cancer history and symptoms On the Web |
American Roentgen Ray Society Images of Hereditary nonpolyposis colorectal cancer history and symptoms |
FDA on Hereditary nonpolyposis colorectal cancer history and symptoms |
CDC on Hereditary nonpolyposis colorectal cancer history and symptoms |
Hereditary nonpolyposis colorectal cancer history and symptoms in the news |
Blogs on Hereditary nonpolyposis colorectal cancer history and symptoms |
Directions to Hospitals Treating Hereditary nonpolyposis colorectal cancer |
Risk calculators and risk factors for Hereditary nonpolyposis colorectal cancer history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
The hallmark of hereditary nonpolyposis colorectal cancer is a first-degree relative with known MMR/EPCAM gene mutation. A positive family history of colorectal cancer and meeting Amsterdam I or II criteria or revised Bethesda guidelines is highly suggestive of HNPCC. Some symptoms that are associated with colorectal cancer are change in bowel habits, hematochezia, and rectal pain.[1]
History
Family History
- Positive history of the disease in a first degree family member
- At least two successive generations affected by HNPCC (histologially confirmed)
- History of colorectal carcinoma and/or endometrial carcinoma or transitional cell carcinoma of the ureter [2]
Symptoms
Colon cancer often causes no symptoms until it has reached a relatively advanced stage. When symptoms do occur, they depend on the site of the lesion. General symptoms include:
- Change in bowel habits
- Change in frequency (constipation and/or diarrhea)
- Change in the quality of stools
- Change in consistency of stools
- Hematochezia or bleeding per rectum
- Mucus in stools
- Abdominal cramps or discomfort
- Melena (usually associated with upper gastrointestinal disease)
- Tenesmus (usually associated with rectal cancer)
- Diminished caliber of stools (usually associated with rectal cancer)
- Rectal pain (usually associated with rectal cancer)
- Nausea/vomiting
- Unexplained weight loss
- Unexplained loss of appetite
- Weakness
- Fatigue
- Dizziness
- Palpitations
- Metrorrhagia in premenopausal women
- Postmenopausal vaginal bleeding [3]
- Postcoital bleeding
References
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.
- ↑ Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 1999;116(6):1453-6.
- ↑ Kong A, Johnson N, Kitchener HC, Lawrie TA (2012). "Adjuvant radiotherapy for stage I endometrial cancer". Cochrane Database Syst Rev. 4: CD003916. doi:10.1002/14651858.CD003916.pub4. PMC 4164955. PMID 22513918.