Hereditary nonpolyposis colorectal cancer history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
*Hereditary nonpolyposis colorectal cancer often causes no symptoms until it has reached a relatively advanced stage. | |||
*When symptoms do occur, they depend on the site of the lesion. | |||
*Common symptoms, include: | |||
* Change in bowel habits | * Change in bowel habits | ||
:* Change in frequency ([[constipation]] and/or [[diarrhea]]) | :* Change in frequency ([[constipation]] and/or [[diarrhea]]) |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
The hallmark of hereditary nonpolyposis colorectal cancer is a first-degree relative with known MMR/EPCAM gene mutation. A positive family history of colorectal cancer and meeting Amsterdam I or II criteria or revised Bethesda guidelines is highly suggestive of hereditary nonpolyposis colorectal cancer. Some symptoms that are associated with colorectal cancer are change in bowel habits, hematochezia, and rectal pain.[1]
History
Family History
- Positive history of the disease in a first degree family member
- At least two successive generations affected by hereditary nonpolyposis colorectal cancer (histologially confirmed)
- History of colorectal carcinoma and/or endometrial carcinoma or transitional cell carcinoma of the ureter [2]
Symptoms
- Hereditary nonpolyposis colorectal cancer often causes no symptoms until it has reached a relatively advanced stage.
- When symptoms do occur, they depend on the site of the lesion.
- Common symptoms, include:
- Change in bowel habits
- Change in frequency (constipation and/or diarrhea)
- Change in the quality of stools
- Change in consistency of stools
- Hematochezia or bleeding per rectum
- Mucus in stools
- Abdominal cramps or discomfort
- Melena (usually associated with upper gastrointestinal disease)
- Tenesmus (usually associated with rectal cancer)
- Diminished caliber of stools (usually associated with rectal cancer)
- Rectal pain (usually associated with rectal cancer)
- Nausea/vomiting
- Unexplained weight loss
- Unexplained loss of appetite
- Weakness
- Fatigue
- Dizziness
- Palpitations
- Metrorrhagia in premenopausal women
- Postmenopausal vaginal bleeding [3]
- Postcoital bleeding
References
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.
- ↑ Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 1999;116(6):1453-6.
- ↑ Kong A, Johnson N, Kitchener HC, Lawrie TA (2012). "Adjuvant radiotherapy for stage I endometrial cancer". Cochrane Database Syst Rev. 4: CD003916. doi:10.1002/14651858.CD003916.pub4. PMC 4164955. PMID 22513918.