Hereditary nonpolyposis colorectal cancer history and symptoms: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (13 intermediate revisions by 4 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Hereditary nonpolyposis colorectal cancer}} | {{Hereditary nonpolyposis colorectal cancer}} | ||
{{CMG}}{{AE}}{{MV}} | {{CMG}}{{AE}}{{MV}}{{Akram}} | ||
==Overview== | ==Overview== | ||
The hallmark of hereditary nonpolyposis colorectal cancer is | The hallmark of hereditary nonpolyposis colorectal cancer is a first-degree relative with known MMR/EPCAM [[gene]] [[mutation]]. A positive [[family history]] of [[colorectal cancer]] and meeting [[Amsterdam criteria|Amsterdam I or II criteria]] or revised Bethesda guidelines is highly suggestive of hereditary nonpolyposis colorectal cancer. Some [[symptoms]] that are associated with [[colorectal cancer]] are change in [[bowel]] habits, [[hematochezia]], and [[rectal pain]]. | ||
==History and | ==History and Symptoms== | ||
=== | === History === | ||
Specific areas of focus when obtaining history, are outlined below:<ref>Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 1999;116(6):1453-6.</ref> | |||
* | :*Positive history of hereditary nonpolyposis colorectal cancer in a first degree [[family]] member | ||
* | :*At least two successive generations affected by hereditary nonpolyposis colorectal cancer ([[Histology|histologically]] confirmed) | ||
:*History of [[Colorectal cancer|colorectal carcinoma]] and/or [[Endometrial cancer|endometrial carcinoma]] or [[transitional cell carcinoma]] of the [[ureter]] | |||
* [[ | |||
=== | ===Common Symptoms=== | ||
* | *Common symptoms include: | ||
* | ** Change in bowel habits: | ||
*** Change in frequency ([[constipation]] and/or [[diarrhea]]) | |||
*** Change in the quality of [[Human feces|stool]] | |||
*** Change in consistency of [[Human feces|stool]] | |||
** [[Hematochezia]] or [[bleeding]] per [[rectum]] | |||
** [[Mucus]] in [[Human feces|stool]] | |||
** [[Abdomen|Abdominal]] [[Cramp|cramps]] or [[discomfort]] | |||
** [[Melena]] (usually associated with upper [[Gastrointestinal tract|gastrointestinal]] [[disease]]) | |||
** [[Tenesmus]] (usually associated with [[Rectum|rectal]] [[cancer]]) | |||
** Diminished caliber of [[Human feces|stool]] (usually associated with [[Rectum|rectal]] [[cancer]]) | |||
** [[Rectum|Rectal]] [[pain]] (usually associated with [[Rectum|rectal]] [[cancer]]) | |||
** [[Nausea and vomiting|Nausea/vomiting]] | |||
** Unexplained [[weight loss]] | |||
** Unexplained [[Anorexia|loss of appetite]] | |||
** [[Fatigue|Weakness]] | |||
** [[Fatigue]] | |||
** [[Metrorrhagia]] in [[Menopause|premenopausal]] women | |||
** [[Menopause|Postmenopausal]] [[vaginal bleeding]] <ref name="pmid22513918">{{cite journal| author=Kong A, Johnson N, Kitchener HC, Lawrie TA| title=Adjuvant radiotherapy for stage I endometrial cancer. | journal=Cochrane Database Syst Rev | year= 2012 | volume= 4 | issue= | pages= CD003916 | pmid=22513918 | doi=10.1002/14651858.CD003916.pub4 | pmc=PMC4164955 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22513918 }} </ref> | |||
** [[Coitus|Postcoital]] [[bleeding]] | |||
==References== | ==References== | ||
| Line 50: | Line 45: | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Gastroenterology]] | |||
[[Category:Surgery]] | |||
Latest revision as of 21:07, 29 April 2019
|
Hereditary Nonpolyposis Colorectal Cancer Microchapters |
|
Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Hereditary nonpolyposis colorectal cancer history and symptoms On the Web |
|
American Roentgen Ray Society Images of Hereditary nonpolyposis colorectal cancer history and symptoms |
|
FDA on Hereditary nonpolyposis colorectal cancer history and symptoms |
|
CDC on Hereditary nonpolyposis colorectal cancer history and symptoms |
|
Hereditary nonpolyposis colorectal cancer history and symptoms in the news |
|
Blogs on Hereditary nonpolyposis colorectal cancer history and symptoms |
|
Directions to Hospitals Treating Hereditary nonpolyposis colorectal cancer |
|
Risk calculators and risk factors for Hereditary nonpolyposis colorectal cancer history and symptoms |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
The hallmark of hereditary nonpolyposis colorectal cancer is a first-degree relative with known MMR/EPCAM gene mutation. A positive family history of colorectal cancer and meeting Amsterdam I or II criteria or revised Bethesda guidelines is highly suggestive of hereditary nonpolyposis colorectal cancer. Some symptoms that are associated with colorectal cancer are change in bowel habits, hematochezia, and rectal pain.
History and Symptoms
History
Specific areas of focus when obtaining history, are outlined below:[1]
- Positive history of hereditary nonpolyposis colorectal cancer in a first degree family member
- At least two successive generations affected by hereditary nonpolyposis colorectal cancer (histologically confirmed)
- History of colorectal carcinoma and/or endometrial carcinoma or transitional cell carcinoma of the ureter
Common Symptoms
- Common symptoms include:
- Change in bowel habits:
- Change in frequency (constipation and/or diarrhea)
- Change in the quality of stool
- Change in consistency of stool
- Hematochezia or bleeding per rectum
- Mucus in stool
- Abdominal cramps or discomfort
- Melena (usually associated with upper gastrointestinal disease)
- Tenesmus (usually associated with rectal cancer)
- Diminished caliber of stool (usually associated with rectal cancer)
- Rectal pain (usually associated with rectal cancer)
- Nausea/vomiting
- Unexplained weight loss
- Unexplained loss of appetite
- Weakness
- Fatigue
- Metrorrhagia in premenopausal women
- Postmenopausal vaginal bleeding [2]
- Postcoital bleeding
- Change in bowel habits:
References
- ↑ Vasen HF, Watson P, Mecklin JP, Lynch HT. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology. 1999;116(6):1453-6.
- ↑ Kong A, Johnson N, Kitchener HC, Lawrie TA (2012). "Adjuvant radiotherapy for stage I endometrial cancer". Cochrane Database Syst Rev. 4: CD003916. doi:10.1002/14651858.CD003916.pub4. PMC 4164955. PMID 22513918.