Hereditary nonpolyposis colorectal cancer epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1] Hereditary nonpolyposis colorectal cancer commonly affects young adult population. The median age of diagnosis is between 40 to 45 years.[1] Hereditary nonpolyposis colorectal cancer affects males and females equally. Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly. Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.[2]</nowiki>
Epidemiology and Demographics
- Incidence of HNPCC is not well known but it is estimated that 0.5 to 13 percent of cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer.
Prevalence
- The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1]
Age
- Hereditary nonpolyposis colorectal cancer commonly affects young adult population.
- The average age of diagnosis is often less than 45 years old.[1]
Gender
- Hereditary nonpolyposis colorectal cancer affects males and females equally.
- In some particular genetic mutations such as MLH1 males have significantly higher risk than females at all ages.[1]
Race
- Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly.
- Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A (1998). "Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease". N. Engl. J. Med. 338 (21): 1481–7. doi:10.1056/NEJM199805213382101. PMID 9593786.
- ↑ Monteiro santos EM, Valentin MD, Carneiro F, et al. Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries. BMC Cancer. 2012;12:64.<nowiki>