Hereditary nonpolyposis colorectal cancer epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
* Incidence of HNPCC is not well known but it is estimated that 0.5 to 13 percent of cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer. | * Incidence of HNPCC is not well known but it is estimated that 0.5 to 13 percent of cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer.<ref name="pmid8162607">{{cite journal| author=Aaltonen LA, Sankila R, Mecklin JP, Järvinen H, Pukkala E, Peltomäki P et al.| title=A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden. | journal=Cancer Detect Prev | year= 1994 | volume= 18 | issue= 1 | pages= 57-63 | pmid=8162607 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8162607 }} </ref><ref name="pmid1503398">{{cite journal| author=Houlston RS, Collins A, Slack J, Morton NE| title=Dominant genes for colorectal cancer are not rare. | journal=Ann Hum Genet | year= 1992 | volume= 56 | issue= Pt 2 | pages= 99-103 | pmid=1503398 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1503398 }} </ref> | ||
===Prevalence=== | ===Prevalence=== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Overview
The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1] Hereditary nonpolyposis colorectal cancer commonly affects young adult population. The median age of diagnosis is between 40 to 45 years.[1] Hereditary nonpolyposis colorectal cancer affects males and females equally. Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly. Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.[2]</nowiki>
Epidemiology and Demographics
- Incidence of HNPCC is not well known but it is estimated that 0.5 to 13 percent of cases of colorectal cancer are due to hereditary nonpolyposis colorectal cancer.[3][4]
Prevalence
- The prevalence of hereditary nonpolyposis colorectal cancer is approximately 2-7% of all diagnosed cases of colorectal cancer.[1]
Age
- Hereditary nonpolyposis colorectal cancer commonly affects young adult population.
- The average age of diagnosis is often less than 45 years old.[1]
Gender
- Hereditary nonpolyposis colorectal cancer affects males and females equally.
- In some particular genetic mutations such as MLH1 males have significantly higher risk than females at all ages.[1]
Race
- Hereditary nonpolyposis colorectal cancer usually affects individuals of the white race more commonly.
- Ethnically-diverse individuals are less likely to develop MMR mutations related with hereditary nonpolyposis colorectal cancer.
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Aaltonen LA, Salovaara R, Kristo P, Canzian F, Hemminki A, Peltomäki P, Chadwick RB, Kääriäinen H, Eskelinen M, Järvinen H, Mecklin JP, de la Chapelle A (1998). "Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease". N. Engl. J. Med. 338 (21): 1481–7. doi:10.1056/NEJM199805213382101. PMID 9593786.
- ↑ Monteiro santos EM, Valentin MD, Carneiro F, et al. Predictive models for mutations in mismatch repair genes: implication for genetic counseling in developing countries. BMC Cancer. 2012;12:64.<nowiki>
- ↑ Aaltonen LA, Sankila R, Mecklin JP, Järvinen H, Pukkala E, Peltomäki P; et al. (1994). "A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden". Cancer Detect Prev. 18 (1): 57–63. PMID 8162607.
- ↑ Houlston RS, Collins A, Slack J, Morton NE (1992). "Dominant genes for colorectal cancer are not rare". Ann Hum Genet. 56 (Pt 2): 99–103. PMID 1503398.