Hereditary nonpolyposis colorectal cancer differential diagnosis: Difference between revisions
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==Overview== | ==Overview== | ||
Hereditary nonpolyposis colorectal cancer must be differentiated from other diseases that cause familial colorectal cancer, such as: | Hereditary nonpolyposis colorectal cancer must be differentiated from other diseases that cause familial colorectal cancer, such as: | ||
[[juvenile polyposis]], [[familial adenomatous polyposis]], [[Cowden syndrome]], and MYH-associated polyposis. | [[juvenile polyposis]], [[familial adenomatous polyposis]], [[Cowden syndrome]], and MYH-associated polyposis. | ||
==Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases== | ==Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases== | ||
HNPCC must be differentiated from other diseases, such as: | HNPCC must be differentiated from other diseases, such as:<ref>Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.</ref> | ||
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Revision as of 00:53, 24 January 2019
Hereditary Nonpolyposis Colorectal Cancer Microchapters |
Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]Ali Akram, M.B.B.S.[3]
Overview
Hereditary nonpolyposis colorectal cancer must be differentiated from other diseases that cause familial colorectal cancer, such as: juvenile polyposis, familial adenomatous polyposis, Cowden syndrome, and MYH-associated polyposis.
Differentiating Hereditary Nonpolyposis Colorectal Cancer from other Diseases
HNPCC must be differentiated from other diseases, such as:[1]
Diseases | History and Symptoms | Physical Examination | Laboratory Findings | Other Findings | ||||||
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Abdominal Pain | Rectal Bleeding | Fatigue | Abdominal Tenderness | Hyperpigmentation | Anemia | Gene(s) | Gastrointestinal Tumors | Cancers | ||
Hereditary Non–Polyposis Colon Cancer | – | + | + | +/– | – | + | ||||
Carney Syndrome | – | – | – | – | – | |||||
Familial Adenomatous Polyposis | + | + | + | +/– | – | + |
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Peutz–Jeghers syndrome | + | + | + | + | + | + |
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Juvenile Polyposis Syndrome | + | + | – | – | – |
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Cowden Syndrome | – | – | – | – | – |
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Differential Diagnosis | Similar Features | Differentiating Features |
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Familial adenomatous polyposis |
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Juvenile polyposis |
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Cowden syndrome |
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References
- ↑ Kladny J, Lubinski J. Lynch syndrome (HNPCC). Hered Cancer Clin Pract. 2008;6(2):99-102.