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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein hairless''' is a [[protein]] that in humans is encoded by the ''HR'' [[gene]].<ref name="pmid10051399">{{cite journal |vauthors=Ahmad W, Zlotogorski A, Panteleyev AA, Lam H, Ahmad M, ul Haque MF, Abdallah HM, Dragan L, Christiano AM | title = Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family | journal = Genomics | volume = 56 | issue = 2 | pages = 141–8 |date=Apr 1999 | pmid = 10051399 | pmc =  | doi = 10.1006/geno.1998.5699 }}</ref><ref name="pmid9463324">{{cite journal |vauthors=Nothen MM, Cichon S, Vogt IR, Hemmer S, Kruse R, Knapp M, Holler T, Faiyaz ul Haque M, Haque S, Propping P, Ahmad M, Rietschel M | title = A gene for universal congenital alopecia maps to chromosome 8p21-22 | journal = Am J Hum Genet | volume = 62 | issue = 2 | pages = 386–90 |date=Apr 1998 | pmid = 9463324 | pmc = 1376893 | doi = 10.1086/301717 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HR hairless homolog (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55806| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Hairless homolog (mouse)
| HGNCid = 5172
| Symbol = HR
| AltSymbols =; AU; ALUNC; HSA277165
| OMIM = 602302
| ECnumber = 
| Homologene = 3774
| MGIid = 96223
| GeneAtlas_image1 = PBB_GE_HR_220163_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HR_210086_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016604 |text = nuclear body}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 55806
    | Hs_Ensembl = ENSG00000168453
    | Hs_RefseqProtein = NP_005135
    | Hs_RefseqmRNA = NM_005144
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 22027873
    | Hs_GenLoc_end = 22045326
    | Hs_Uniprot = O43593
    | Mm_EntrezGene = 15460
    | Mm_Ensembl = ENSMUSG00000022096
    | Mm_RefseqmRNA = NM_021877
    | Mm_RefseqProtein = NP_068677
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 69289136
    | Mm_GenLoc_end = 69308630
    | Mm_Uniprot = Q4QY90
  }}
}}
'''Hairless homolog (mouse)''', also known as '''HR''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HR hairless homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55806| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases. Mutations in this gene have been documented in cases of autosomal recessive congenital alopecia and atrichia with papular lesions.<ref name="entrez">{{cite web | title = Entrez Gene: HR hairless homolog (mouse)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55806| accessdate = }}</ref>
| summary_text = This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for [[thyroid hormone]] and interacts with [[histone deacetylases]].<ref name="entrez" />
}}
}}
==Human Genetics==
Variations in this gene is involved in low levels of hair (baldness / [[alopecia]] / [[hypotrichosis]])<ref>{{cite journal | journal=Clin Exp Dermatol. | date=Mar 2016 | volume=41 |issue=2 |pages=175-8 | title=Identification of mutations in U2HR in two Chinese families with Marie Unna hereditary hypotrichosis |author=Zhong Z, Zhong M, Lu Y, Lu L, Wang J, Xu D, Wang F, Xu G, Chen J}}</ref>  Mutations in this gene in humans have been documented in cases of autosomal recessive congenital [[alopecia]] <ref>{{cite journal  | author=Ahmad W |title=Alopecia universalis associated with a mutation in the human hairless gene |journal=Science |volume=279 |issue= 5351 |pages= 720–4 |year= 1998 |pmid= 9445480 |doi=10.1126/science.279.5351.720  |name-list-format=vanc| author2=Faiyaz ul Haque M  | author3=Brancolini V  | display-authors=3  | last4=Tsou  | first4=HC  | last5=Ul Haque  | first5=S  | last6=Lam  | first6=H  | last7=Aita  | first7=VM  | last8=Owen  | first8=J  | last9=Deblaquiere  | first9=M  }}</ref> and  [[atrichia with papular lesions]].<ref name=hr1>{{cite journal  | author=Ahmad W |title=A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers |journal=Am. J. Hum. Genet. |volume=63 |issue= 4 |pages= 984–91 |year= 1998 |pmid= 9758627 |doi=10.1086/302069 |pmc=1377501 |name-list-format=vanc|author2=Irvine AD |author3=Lam H |display-authors=3 |last4=Buckley |first4=Colin |last5=Bingham |first5=E. Ann |last6=Panteleyev |first6=Andrei A. |last7=Ahmad |first7=Mahmud |last8=McGrath |first8=John A. |last9=Christiano |first9=Angela M.}}</ref><ref>{{cite journal |author=Sprecher E |title=Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias |journal=Am. J. Hum. Genet. |volume=64 |issue= 5 |pages= 1323–9 |year= 1999 |pmid= 10205263 |doi=10.1086/302368 |pmc=1377868 |name-list-format=vanc|author2=Bergman R |author3=Szargel R |display-authors=3 |last4=Friedman-Birnbaum |first4=Rachel |last5=Cohen |first5=Nadine}}</ref>
<ref name=hr2>{{cite journal  | author=Ahmad W |title=A homozygous nonsense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia |journal=J. Invest. Dermatol. |volume=113 |issue= 2 |pages= 281–3 |year= 1999 |pmid= 10469319 |doi= 10.1046/j.1523-1747.1999.00686.x  |name-list-format=vanc| author2=Nomura K  | author3=McGrath JA |display-authors=3 |last4=Hashimoto  | first4=Isao  | last5=Christiano  | first5=s}}</ref>
<ref>{{cite journal  | author=Hillmer AM |title=Variant 1859G→A (Arg620Gln) of the "Hairless" Gene: Absence of Association with Papular Atrichia or Androgenetic Alopecia |journal=Am. J. Hum. Genet. |volume=69 |issue= 1 |pages= 235–7 |year= 2001 |pmid= 11410842 |doi=10.1086/321273  | pmc=1226040  |name-list-format=vanc| author2=Kruse R  | author3=Betz RC  | display-authors=3  | last4=Schumacher  | first4=Johannes  | last5=Heyn  | first5=Uwe  | last6=Propping  | first6=Peter  | last7=Nöthen  | first7=Markus M.  | last8=Cichon  | first8=Sven  }}</ref>
<ref>{{cite journal  | author=Potter GB |title=The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2687–701 |year= 2001 |pmid= 11641275 |doi= 10.1101/gad.916701  | pmc=312820  |name-list-format=vanc| author2=Beaudoin GM  | author3=DeRenzo CL  | display-authors=3  | last4=Zarach  | first4=JM  | last5=Chen  | first5=SH  | last6=Thompson  | first6=CC }}</ref>
The protein contains a [[Zinc finger]] domain.<ref name=hr2/><ref name=hr1/>
==See also==
*[[Corepressor (genetics)|Corepressor]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ahmad M, Abbas H, Haque S |title=Alopecia universalis as a single abnormality in an inbred Pakistani kindred. |journal=Am. J. Med. Genet. |volume=46 |issue= 4 |pages= 369-71 |year= 1993 |pmid= 8357006 |doi= 10.1002/ajmg.1320460405 }}
*{{cite journal  |vauthors=Ahmad M, Abbas H, Haque S |title=Alopecia universalis as a single abnormality in an inbred Pakistani kindred |journal=Am. J. Med. Genet. |volume=46 |issue= 4 |pages= 369–71 |year= 1993 |pmid= 8357006 |doi= 10.1002/ajmg.1320460405 }}
*{{cite journal  | author=Ahmad W, Faiyaz ul Haque M, Brancolini V, ''et al.'' |title=Alopecia universalis associated with a mutation in the human hairless gene. |journal=Science |volume=279 |issue= 5351 |pages= 720-4 |year= 1998 |pmid= 9445480 |doi=  }}
*{{cite journal  | author=Cichon S |title=Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1671–9 |year= 1998 |pmid= 9736769 |doi=10.1093/hmg/7.11.1671 |name-list-format=vanc| author2=Anker M | author3=Vogt IR | display-authors=3  | last4=Rohleder  | first4=H  | last5=Pützstück  | first5=M  | last6=Hillmer  | first6=A  | last7=Farooq  | first7=SA  | last8=Al-Dhafri  | first8=KS  | last9=Ahmad  | first9=M }}
*{{cite journal | author=Nöthen MM, Cichon S, Vogt IR, ''et al.'' |title=A gene for universal congenital alopecia maps to chromosome 8p21-22. |journal=Am. J. Hum. Genet. |volume=62 |issue= 2 |pages= 386-90 |year= 1998 |pmid= 9463324 |doi=  }}
*{{cite journal  |vauthors=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021–8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
*{{cite journal  | author=Cichon S, Anker M, Vogt IR, ''et al.'' |title=Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia. |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1671-9 |year= 1998 |pmid= 9736769 |doi= }}
*{{cite journal  | author=Hillmer AM |title=The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach |journal=Br. J. Dermatol. |volume=146 |issue= 4 |pages= 601–8 |year= 2002 |pmid= 11966690 |doi=10.1046/j.1365-2133.2002.04766.x |name-list-format=vanc| author2=Kruse R  | author3=Macciardi F  | display-authors=3  | last4=Heyn  | first4=U.  | last5=Betz  | first5=R.C.  | last6=Ruzicka  | first6=T. | last7=Propping  | first7=P.  | last8=Nothen  | first8=M.M. | last9=Cichon  | first9=S.  }}
*{{cite journal  | author=Ahmad W, Irvine AD, Lam H, ''et al.'' |title=A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers. |journal=Am. J. Hum. Genet. |volume=63 |issue= 4 |pages= 984-91 |year= 1998 |pmid= 9758627 |doi=  }}
*{{cite journal  | author=Henn W |title=Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis |journal=J. Am. Acad. Dermatol. |volume=47 |issue= 4 |pages= 519–23 |year= 2002 |pmid= 12271294 |doi=10.1067/mjd.2002.124609 |name-list-format=vanc| author2=Zlotogorski A | author3=Lam H  | display-authors=3  | last4=Martinez-Mir  | first4=Amalia  | last5=Zaun  | first5=Hansotto  | last6=Christiano  | first6=Angela M. }}
*{{cite journal  | author=Ahmad W, Zlotogorski A, Panteleyev AA, ''et al.'' |title=Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family. |journal=Genomics |volume=56 |issue= 2 |pages= 141-8 |year= 1999 |pmid= 10051399 |doi= 10.1006/geno.1998.5699 }}
*{{cite journal  |vauthors=Klein I, Bergman R, Indelman M, Sprecher E |title=A novel missense mutation affecting the human hairless thyroid receptor interacting domain 2 causes congenital atrichia |journal=J. Invest. Dermatol. |volume=119 |issue= 4 |pages= 920–2 |year= 2002 |pmid= 12406339 |doi= 10.1046/j.1523-1747.2002.00268.x }}
*{{cite journal  | author=Sprecher E, Bergman R, Szargel R, ''et al.'' |title=Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias. |journal=Am. J. Hum. Genet. |volume=64 |issue= 5 |pages= 1323-9 |year= 1999 |pmid= 10205263 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Ahmad W, Nomura K, McGrath JA, ''et al.'' |title=A homozygous nonsense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia. |journal=J. Invest. Dermatol. |volume=113 |issue= 2 |pages= 281-3 |year= 1999 |pmid= 10469319 |doi= 10.1046/j.1523-1747.1999.00686.x }}
*{{cite journal  | author=Fernández A |title=Linkage mapping of the porcine hairless gene (HR ) to chromosome 14 |journal=Anim. Genet. |volume=34 |issue= 4 |pages= 317–8 |year= 2004 |pmid= 12873232 |doi=10.1046/j.1365-2052.2003.01032.x |name-list-format=vanc| author2=Silió L  | author3=Noguera JL  | display-authors=3  | last4=Sanchez  | first4=A. | last5=Ovilo  | first5=C. }}
*{{cite journal  | author=Hillmer AM, Kruse R, Betz RC, ''et al.'' |title=Variant 1859G-->A (Arg620Gln) of the "hairless" gene: absence of association with papular atrichia or androgenic alopecia. |journal=Am. J. Hum. Genet. |volume=69 |issue= 1 |pages= 235-7 |year= 2001 |pmid= 11410842 |doi= }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Potter GB, Beaudoin GM, DeRenzo CL, ''et al.'' |title=The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor. |journal=Genes Dev. |volume=15 |issue= 20 |pages= 2687-701 |year= 2001 |pmid= 11641275 |doi= 10.1101/gad.916701 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein | first7=SL | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
*{{cite journal |vauthors=Xie Z, Chang S, Oda Y, Bikle DD |title=Hairless suppresses vitamin D receptor transactivation in human keratinocytes |journal=Endocrinology |volume=147 |issue= 1 |pages= 314–23 |year= 2006 |pmid= 16269453 |doi= 10.1210/en.2005-1111 }}
*{{cite journal  | author=Hillmer AM, Kruse R, Macciardi F, ''et al.'' |title=The hairless gene in androgenetic alopecia: results of a systematic mutation screening and a family-based association approach. |journal=Br. J. Dermatol. |volume=146 |issue= 4 |pages= 601-8 |year= 2002 |pmid= 11966690 |doi=  }}
*{{cite journal  | author=Betz RC |title=Identification of mutations in the human hairless gene in two new families with congenital atrichia |journal=Arch. Dermatol. Res. |volume=299 |issue= 3 |pages= 157–61 |year= 2007 |pmid= 17372750 |doi= 10.1007/s00403-007-0747-8 |name-list-format=vanc| author2=Indelman M  | author3=Pforr J  | display-authors=3  | last4=Schreiner  | first4=Felix  | last5=Bauer  | first5=Ralf  | last6=Bergman  | first6=Reuven  | last7=Lentze  | first7=Michael J.  | last8=Nöthen  | first8=Markus M.  | last9=Cichon  | first9=Sven }}
*{{cite journal  | author=Henn W, Zlotogorski A, Lam H, ''et al.'' |title=Atrichia with papular lesions resulting from compound heterozygous mutations in the hairless gene: A lesson for differential diagnosis of alopecia universalis. |journal=J. Am. Acad. Dermatol. |volume=47 |issue= 4 |pages= 519-23 |year= 2002 |pmid= 12271294 |doi= }}
*{{cite journal | author=Klein I, Bergman R, Indelman M, Sprecher E |title=A novel missense mutation affecting the human hairless thyroid receptor interacting domain 2 causes congenital atrichia. |journal=J. Invest. Dermatol. |volume=119 |issue= 4 |pages= 920-2 |year= 2002 |pmid= 12406339 |doi= 10.1046/j.1523-1747.2002.00268.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Fernández A, Silió L, Noguera JL, ''et al.'' |title=Linkage mapping of the porcine hairless gene (HR ) to chromosome 14. |journal=Anim. Genet. |volume=34 |issue= 4 |pages= 317-8 |year= 2004 |pmid= 12873232 |doi=  }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Xie Z, Chang S, Oda Y, Bikle DD |title=Hairless suppresses vitamin D receptor transactivation in human keratinocytes. |journal=Endocrinology |volume=147 |issue= 1 |pages= 314-23 |year= 2006 |pmid= 16269453 |doi= 10.1210/en.2005-1111 }}
*{{cite journal | author=Betz RC, Indelman M, Pforr J, ''et al.'' |title=Identification of mutations in the human hairless gene in two new families with congenital atrichia. |journal=Arch. Dermatol. Res. |volume=299 |issue= 3 |pages= 157-61 |year= 2007 |pmid= 17372750 |doi= 10.1007/s00403-007-0747-8 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{MeshName|HR+protein,+human}}
 
{{Transcription coregulators}}
 
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[[Category:Transcription coregulators]]
 
 
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Revision as of 14:03, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein hairless is a protein that in humans is encoded by the HR gene.[1][2][3]


This gene encodes a protein whose function has been linked to hair growth. A similar protein in rat functions as a transcriptional corepressor for thyroid hormone and interacts with histone deacetylases.[3]

Human Genetics

Variations in this gene is involved in low levels of hair (baldness / alopecia / hypotrichosis)[4] Mutations in this gene in humans have been documented in cases of autosomal recessive congenital alopecia [5] and atrichia with papular lesions.[6][7] [8] [9] [10]

The protein contains a Zinc finger domain.[8][6]

See also

References

  1. ↑ Ahmad W, Zlotogorski A, Panteleyev AA, Lam H, Ahmad M, ul Haque MF, Abdallah HM, Dragan L, Christiano AM (Apr 1999). "Genomic organization of the human hairless gene (HR) and identification of a mutation underlying congenital atrichia in an Arab Palestinian family". Genomics. 56 (2): 141–8. doi:10.1006/geno.1998.5699. PMID 10051399.
  2. ↑ Nothen MM, Cichon S, Vogt IR, Hemmer S, Kruse R, Knapp M, Holler T, Faiyaz ul Haque M, Haque S, Propping P, Ahmad M, Rietschel M (Apr 1998). "A gene for universal congenital alopecia maps to chromosome 8p21-22". Am J Hum Genet. 62 (2): 386–90. doi:10.1086/301717. PMC 1376893. PMID 9463324.
  3. ↑ 3.0 3.1 "Entrez Gene: HR hairless homolog (mouse)".
  4. ↑ Zhong Z, Zhong M, Lu Y, Lu L, Wang J, Xu D, Wang F, Xu G, Chen J (Mar 2016). "Identification of mutations in U2HR in two Chinese families with Marie Unna hereditary hypotrichosis". Clin Exp Dermatol. 41 (2): 175–8.
  5. ↑ Ahmad W, Faiyaz ul Haque M, Brancolini V, et al. (1998). "Alopecia universalis associated with a mutation in the human hairless gene". Science. 279 (5351): 720–4. doi:10.1126/science.279.5351.720. PMID 9445480.
  6. ↑ 6.0 6.1 Ahmad W, Irvine AD, Lam H, et al. (1998). "A missense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia in a family of Irish travellers". Am. J. Hum. Genet. 63 (4): 984–91. doi:10.1086/302069. PMC 1377501. PMID 9758627.
  7. ↑ Sprecher E, Bergman R, Szargel R, et al. (1999). "Identification of a genetic defect in the hairless gene in atrichia with papular lesions: evidence for phenotypic heterogeneity among inherited atrichias". Am. J. Hum. Genet. 64 (5): 1323–9. doi:10.1086/302368. PMC 1377868. PMID 10205263.
  8. ↑ 8.0 8.1 Ahmad W, Nomura K, McGrath JA, et al. (1999). "A homozygous nonsense mutation in the zinc-finger domain of the human hairless gene underlies congenital atrichia". J. Invest. Dermatol. 113 (2): 281–3. doi:10.1046/j.1523-1747.1999.00686.x. PMID 10469319.
  9. ↑ Hillmer AM, Kruse R, Betz RC, et al. (2001). "Variant 1859G→A (Arg620Gln) of the "Hairless" Gene: Absence of Association with Papular Atrichia or Androgenetic Alopecia". Am. J. Hum. Genet. 69 (1): 235–7. doi:10.1086/321273. PMC 1226040. PMID 11410842.
  10. ↑ Potter GB, Beaudoin GM, DeRenzo CL, et al. (2001). "The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor". Genes Dev. 15 (20): 2687–701. doi:10.1101/gad.916701. PMC 312820. PMID 11641275.

Further reading

External links


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