Graft-versus-host disease risk factors

Graft-versus-host disease
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Risk calculators and risk factors for Graft-versus-host disease risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]

Risk Factors

Risk factors for GvHD include:

• High degree of HLA disparity between host and donor cells
• Use of unrelated donors as the stem cell source
• Total body irradiation as the conditioning regimen prior to transplant

Protective risk factors include:

• High degree of HLA concordance between the host and donor
• Use of umbilical cord blood as the donor source (given decreased number of donor T cells)