Graft-versus-host disease risk factors: Difference between revisions

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*Use of unrelated donors as the stem cell source<ref name="pmid22770714">{{cite journal| author=Rezvani AR, Storb RF| title=Prevention of graft-vs.-host disease. | journal=Expert Opin Pharmacother | year= 2012 | volume= 13 | issue= 12 | pages= 1737-50 | pmid=22770714 | doi=10.1517/14656566.2012.703652 | pmc=3509175 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22770714  }} </ref>
*Use of unrelated donors as the stem cell source<ref name="pmid22770714">{{cite journal| author=Rezvani AR, Storb RF| title=Prevention of graft-vs.-host disease. | journal=Expert Opin Pharmacother | year= 2012 | volume= 13 | issue= 12 | pages= 1737-50 | pmid=22770714 | doi=10.1517/14656566.2012.703652 | pmc=3509175 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22770714  }} </ref>
*Total body irradiation as the conditioning regimen prior to transplant<ref name="pmid22770714">{{cite journal| author=Rezvani AR, Storb RF| title=Prevention of graft-vs.-host disease. | journal=Expert Opin Pharmacother | year= 2012 | volume= 13 | issue= 12 | pages= 1737-50 | pmid=22770714 | doi=10.1517/14656566.2012.703652 | pmc=3509175 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22770714  }} </ref>
*Total body irradiation as the conditioning regimen prior to transplant<ref name="pmid22770714">{{cite journal| author=Rezvani AR, Storb RF| title=Prevention of graft-vs.-host disease. | journal=Expert Opin Pharmacother | year= 2012 | volume= 13 | issue= 12 | pages= 1737-50 | pmid=22770714 | doi=10.1517/14656566.2012.703652 | pmc=3509175 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22770714  }} </ref>
*Prior acute GvHD<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139  }} </ref>
*Use of peripheral blood stem cells<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139  }} </ref>
*Use of a T-cell replete graft<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139  }} </ref>
*Viral infection, since this can contribute to immune activation<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139  }} </ref>
*Male host<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139  }} </ref>
*Multiparous female donor<ref name="pmid24914139">{{cite journal| author=Socié G, Ritz J| title=Current issues in chronic graft-versus-host disease. | journal=Blood | year= 2014 | volume= 124 | issue= 3 | pages= 374-84 | pmid=24914139 | doi=10.1182/blood-2014-01-514752 | pmc=4102710 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24914139  }} </ref>


Protective risk factors include:
Protective risk factors include:

Revision as of 02:39, 18 June 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]

Overview

Risk Factors

Risk factors for GvHD include:

  • High degree of HLA disparity between host and donor cells[1]
  • Use of unrelated donors as the stem cell source[1]
  • Total body irradiation as the conditioning regimen prior to transplant[1]
  • Prior acute GvHD[2]
  • Use of peripheral blood stem cells[2]
  • Use of a T-cell replete graft[2]
  • Viral infection, since this can contribute to immune activation[2]
  • Male host[2]
  • Multiparous female donor[2]


Protective risk factors include:

  • High degree of HLA concordance between the host and donor
  • Use of umbilical cord blood as the donor source (given decreased number of donor T cells)

References

  1. ↑ 1.0 1.1 1.2 Rezvani AR, Storb RF (2012). "Prevention of graft-vs.-host disease". Expert Opin Pharmacother. 13 (12): 1737–50. doi:10.1517/14656566.2012.703652. PMC 3509175. PMID 22770714.
  2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Socié G, Ritz J (2014). "Current issues in chronic graft-versus-host disease". Blood. 124 (3): 374–84. doi:10.1182/blood-2014-01-514752. PMC 4102710. PMID 24914139.

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