Glucagonoma medical therapy: Difference between revisions
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=== Management of primary tumor === | === Management of primary tumor === | ||
* Somatostatin analogs (octreotide) are the treatment of choice to control symptoms.<ref name="pmid25489112">{{cite journal| author=Rosenbaum A, Flourie B, Chagnon S, Blery M, Modigliani R| title=Octreotide (SMS 201-995) in the treatment of metastatic glucagonoma: report of one case and review of the literature. | journal=Digestion | year= 1989 | volume= 42 | issue= 2 | pages= 116-20 | pmid=2548911 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2548911 }}</ref> | * [[Somatostatin|Somatostatin analogs]] ([[octreotide]]) are the treatment of choice to control symptoms.<ref name="pmid25489112">{{cite journal| author=Rosenbaum A, Flourie B, Chagnon S, Blery M, Modigliani R| title=Octreotide (SMS 201-995) in the treatment of metastatic glucagonoma: report of one case and review of the literature. | journal=Digestion | year= 1989 | volume= 42 | issue= 2 | pages= 116-20 | pmid=2548911 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2548911 }}</ref> | ||
* [[Doxorubicin]] and [[streptozotocin]] have also been used successfully to selectively damage alpha cells of the pancreatic islets. | * [[Doxorubicin]] and [[streptozotocin]] have also been used successfully to selectively damage [[alpha cells]] of the pancreatic islets. | ||
=== Metastasis therapy === | === Metastasis therapy === | ||
==== '''Hepatic artery''' '''embolization''' ==== | ==== [[Therapeutic embolization|'''Hepatic artery''' '''embolization''']] ==== | ||
*Hepatic arterial embolization is a palliative treatment in patients with symptomatic hepatic metastases who are not candidates for surgical resection. Embolization can be performed via the infusion through an angiography catheter into hepatic arteries. | *Hepatic arterial [[embolization]] is a palliative treatment in patients with symptomatic [[Hepatic metastasis|hepatic metastases]] who are not candidates for surgical resection. [[Therapeutic embolization|Embolization]] can be performed via the infusion through an [[Angiography|angiography catheter]] into [[hepatic arteries]]. | ||
==== '''Radiofrequency ablation''' ==== | ==== '''Radiofrequency ablation''' ==== | ||
*Ablation can be performed percutaneously or laparoscopically in patients with symptomatic hepatic metastases who are not candidates for surgical resection. Ablation is applicable only to smaller lesions less than 3 cm.<ref name="pmid12967136">{{cite journal| author=Gupta S, Yao JC, Ahrar K, Wallace MJ, Morello FA, Madoff DC et al.| title=Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience. | journal=Cancer J | year= 2003 | volume= 9 | issue= 4 | pages= 261-7 | pmid=12967136 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12967136 }}</ref> | *[[Ablation]] can be performed [[percutaneously]] or [[Laparoscopic surgery|laparoscopically]] in patients with symptomatic hepatic metastases who are not candidates for surgical resection. Ablation is applicable only to smaller lesions less than 3 cm.<ref name="pmid12967136">{{cite journal| author=Gupta S, Yao JC, Ahrar K, Wallace MJ, Morello FA, Madoff DC et al.| title=Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience. | journal=Cancer J | year= 2003 | volume= 9 | issue= 4 | pages= 261-7 | pmid=12967136 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12967136 }}</ref> | ||
==== '''Molecularly therapy''' ==== | ==== '''Molecularly therapy''' ==== | ||
*Sunitinib is a radiolabeled somatostatin analog which has a role in the management of glucagonomas that are not symptomatic or have rapidly progressive metastasis. | *[[Sunitinib]] is a radiolabeled [[somatostatin]] analog which has a role in the management of glucagonomas that are not symptomatic or have rapidly progressive metastasis. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 19:19, 2 August 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
The predominant therapy for glucagonoma is surgical resection. Adjunctive chemotherapy may be required.
Medical Therapy
Management of primary tumor
- Somatostatin analogs (octreotide) are the treatment of choice to control symptoms.[1]
- Doxorubicin and streptozotocin have also been used successfully to selectively damage alpha cells of the pancreatic islets.
Metastasis therapy
Hepatic artery embolization
- Hepatic arterial embolization is a palliative treatment in patients with symptomatic hepatic metastases who are not candidates for surgical resection. Embolization can be performed via the infusion through an angiography catheter into hepatic arteries.
Radiofrequency ablation
- Ablation can be performed percutaneously or laparoscopically in patients with symptomatic hepatic metastases who are not candidates for surgical resection. Ablation is applicable only to smaller lesions less than 3 cm.[2]
Molecularly therapy
- Sunitinib is a radiolabeled somatostatin analog which has a role in the management of glucagonomas that are not symptomatic or have rapidly progressive metastasis.
References
- ↑ Rosenbaum A, Flourie B, Chagnon S, Blery M, Modigliani R (1989). "Octreotide (SMS 201-995) in the treatment of metastatic glucagonoma: report of one case and review of the literature". Digestion. 42 (2): 116–20. PMID 2548911.
- ↑ Gupta S, Yao JC, Ahrar K, Wallace MJ, Morello FA, Madoff DC; et al. (2003). "Hepatic artery embolization and chemoembolization for treatment of patients with metastatic carcinoid tumors: the M.D. Anderson experience". Cancer J. 9 (4): 261–7. PMID 12967136.