Gastrointestinal stromal tumor staging: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{CMG}}{{AE}}{{PSD}} | {{CMG}}{{AE}}{{PSD}} | ||
{{Gastrointestinal stromal tumor}} | {{Gastrointestinal stromal tumor}} | ||
==Overview== | ==Overview== | ||
According to the American Joint Committee on Cancer, there are 4 stages of | According to the American Joint Committee on Cancer, there are 4 stages of gastrointestinal stromal tumor based on the [[tumor]] spread. | ||
==Stage Information for GIST== | ==Stage Information for GIST== | ||
According to the [[TNM]] (for GIST at All Sites) a formal [[Staging (pathology)|staging]] system for gastrointestinal stromal tumors (GIST) appeared for the first time in the 7th edition of the [[American Joint Committee on Cancer]] ([[American Joint Committee on Cancer|AJCC]]), [[Cancer]] [[Cancer staging|Staging]] Manual. Because of the limited availability of [[mutation]] testing, [[mutation]] status is not included in the [[American Joint Committee on Cancer|AJCC]] system. In addition, since nodal involvement is so rare, and nodal dissection is not indicated, the designation N0/pN0 should be used in the absence of information about the regional nodes. Note that treatment decisions may not be based strictly on the stage of [[disease]]. | |||
==Definitions of TNM (for GIST at All Sites)== | ==Definitions of TNM (for GIST at All Sites)== | ||
===Primary tumor=== | ===Primary tumor=== | ||
*TX:Primary tumor cannot be assessed | *TX: Primary [[tumor]] cannot be assessed | ||
*T0:No evidence for primary tumor | *T0: No evidence for primary [[tumor]] | ||
*T1:Tumor ≤2 cm | *T1: [[Tumor]] ≤2 cm | ||
*T2:Tumor >2 cm but not >5 cm | *T2: [[Tumor]] >2 cm but not >5 cm | ||
*T3:Tumor >5 cm but not >10 cm | *T3: [[Tumor]] >5 cm but not >10 cm | ||
*T4:Tumor >10 cm in greatest dimension | *T4: [[Tumor]] >10 cm in greatest dimension | ||
===Regional Lymph Nodes (N)=== | ===Regional Lymph Nodes (N)=== | ||
*NX:Regional lymph nodes cannot be assessed | *NX: Regional [[Lymph node|lymph nodes]] cannot be assessed | ||
*N0:No regional lymph node metastasis | *N0: No regional [[lymph node]] [[metastasis]] | ||
*N1:Regional lymph node metastasis | *N1: Regional [[lymph node]] [[metastasis]] | ||
===Distant Metastasis (M)=== | ===Distant Metastasis (M)=== | ||
*M0:No distant metastasis | *M0: No distant [[metastasis]] | ||
*M1:Distant metastasis | *M1: Distant [[metastasis]] | ||
==Anatomic Stage/Prognostic Groups== | ==Anatomic Stage/Prognostic Groups== | ||
===Gastric GIST=== | ===Gastric GIST=== | ||
{| {{table}} | <ref>{{Cite web | title = Stage Information for GIST | ||
| align="center" style="background:# | | url =http://www.cancer.gov/types/soft-tissue-sarcoma/hp/gist-treatment-pdq#section/_32 }}</ref> | ||
| align="center" style="background:# | {| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;" | ||
| align="center" style="background:# | | align="center" style="background:#4479BA" |'''Group''' | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''T''' | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''N''' | ||
| align="center" style="background:#4479BA;" |'''M''' | |||
| align="center" style="background:#4479BA;" |'''Mitotic Rate''' | |||
|- | |- | ||
| Stage IA||T1 or T2||N0||M0||Low | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IA||T1 or T2||N0||M0||Low | ||
|- | |- | ||
| Stage IB||T3||N0||M0||Low | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IB||T3||N0||M0||Low | ||
|- | |- | ||
| Stage II||T1||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage II||T1||N0||M0||High | ||
|- | |- | ||
| ||T2||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||T2||N0||M0||High | ||
|- | |- | ||
| ||T4||N0||M0||Low | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||T4||N0||M0||Low | ||
|- | |- | ||
| Stage IIIA||T3||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IIIA||T3||N0||M0||High | ||
|- | |- | ||
| Stage IIIB||T4||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IIIB||T4||N0||M0||High | ||
|- | |- | ||
| Stage IV||Any T||N1||M0||Any rate | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IV||Any T||N1||M0||Any rate | ||
|- | |- | ||
| ||Any T||Any N||M1||Any rate | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||Any T||Any N||M1||Any rate | ||
|- | |- | ||
|} | |} | ||
===Small Intestine GIST=== | ===Small Intestine GIST=== | ||
<ref>{{Cite web | title = Stage Information for GIST | |||
| url =http://www.cancer.gov/types/soft-tissue-sarcoma/hp/gist-treatment-pdq#section/_32 }}</ref> | |||
{| {{table}} | {| {{table}} cellpadding="4" cellspacing="0" style="border:#c9c9c9 1px solid; margin: 1em 1em 1em 0; border-collapse: collapse;" | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''Group''' | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''T''' | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''N''' | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''M''' | ||
| align="center" style="background:# | | align="center" style="background:#4479BA;" |'''Mitotic rate''' | ||
|- | |- | ||
| Stage I||T1 or T2||N0||M0||Low | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage I||T1 or T2||N0||M0||Low | ||
|- | |- | ||
| Stage II||T3||N0||M0||Low | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage II||T3||N0||M0||Low | ||
|- | |- | ||
| Stage IIIA||T1||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IIIA||T1||N0||M0||High | ||
|- | |- | ||
| ||T4||N0||M0||Low | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||T4||N0||M0||Low | ||
|- | |- | ||
| Stage IIIB||T2||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IIIB||T2||N0||M0||High | ||
|- | |- | ||
| ||T3||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||T3||N0||M0||High | ||
|- | |- | ||
| ||T4||N0||M0||High | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||T4||N0||M0||High | ||
|- | |- | ||
| Stage IV||Any T||N1||M0||Any rate | | style="background: #DCDCDC; padding: 5px; text-align: center;" | Stage IV||Any T||N1||M0||Any rate | ||
|- | |- | ||
| ||Any T||Any N||M1||Any rate | | style="background: #DCDCDC; padding: 5px; text-align: center;" | ||Any T||Any N||M1||Any rate | ||
|- | |- | ||
|} | |} | ||
==References== | ==References== | ||
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{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
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[[Category:Surgery]] |
Latest revision as of 22:41, 6 March 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Gastrointestinal stromal tumor Microchapters |
Differentiating Gastrointestinal stromal tumor from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Gastrointestinal stromal tumor staging On the Web |
American Roentgen Ray Society Images of Gastrointestinal stromal tumor staging |
Directions to Hospitals Treating Gastrointestinal stromal tumor |
Risk calculators and risk factors for Gastrointestinal stromal tumor staging |
Overview
According to the American Joint Committee on Cancer, there are 4 stages of gastrointestinal stromal tumor based on the tumor spread.
Stage Information for GIST
According to the TNM (for GIST at All Sites) a formal staging system for gastrointestinal stromal tumors (GIST) appeared for the first time in the 7th edition of the American Joint Committee on Cancer (AJCC), Cancer Staging Manual. Because of the limited availability of mutation testing, mutation status is not included in the AJCC system. In addition, since nodal involvement is so rare, and nodal dissection is not indicated, the designation N0/pN0 should be used in the absence of information about the regional nodes. Note that treatment decisions may not be based strictly on the stage of disease.
Definitions of TNM (for GIST at All Sites)
Primary tumor
- TX: Primary tumor cannot be assessed
- T0: No evidence for primary tumor
- T1: Tumor ≤2 cm
- T2: Tumor >2 cm but not >5 cm
- T3: Tumor >5 cm but not >10 cm
- T4: Tumor >10 cm in greatest dimension
Regional Lymph Nodes (N)
- NX: Regional lymph nodes cannot be assessed
- N0: No regional lymph node metastasis
- N1: Regional lymph node metastasis
Distant Metastasis (M)
- M0: No distant metastasis
- M1: Distant metastasis
Anatomic Stage/Prognostic Groups
Gastric GIST
Group | T | N | M | Mitotic Rate |
Stage IA | T1 or T2 | N0 | M0 | Low |
Stage IB | T3 | N0 | M0 | Low |
Stage II | T1 | N0 | M0 | High |
T2 | N0 | M0 | High | |
T4 | N0 | M0 | Low | |
Stage IIIA | T3 | N0 | M0 | High |
Stage IIIB | T4 | N0 | M0 | High |
Stage IV | Any T | N1 | M0 | Any rate |
Any T | Any N | M1 | Any rate |
Small Intestine GIST
Group | T | N | M | Mitotic rate |
Stage I | T1 or T2 | N0 | M0 | Low |
Stage II | T3 | N0 | M0 | Low |
Stage IIIA | T1 | N0 | M0 | High |
T4 | N0 | M0 | Low | |
Stage IIIB | T2 | N0 | M0 | High |
T3 | N0 | M0 | High | |
T4 | N0 | M0 | High | |
Stage IV | Any T | N1 | M0 | Any rate |
Any T | Any N | M1 | Any rate |
References