Fibromuscular dysplasia

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-in-Chief: Shantanu Sinha, MD,FACC

Overview

Fibromuscular dysplasia (FMD) is a disease that can cause stenosis of the renal arteries, carotid arteries, and less commonly, the arteries of the abdomen. The disease can cause hypertension, strokes, and arterial aneurysm and dissection.

Epidemiology and Demographics

Age

Fibromuscular dysplasia tends to occur in females between 14 and 50 years of age. However, it has been found in children under the age of 14.

Sex

Fibromuscular dysplasia affects females more than males.

Pathophysiology

In individuals with FMD, the walls of one or more arteries undergo dysplasia. Due to this abnormal cellular development, the vessels may become stenosed. A sufficient decrease in blood flow through the artery can cause symptoms. Fibromuscular dysplasia is characterized by fibrous thickening of the intima, media, or adventitia of the renal artery. Up to 75% of all patients with FMD will have disease in the renal arteries. The lesions cause narrowing of the artery lumen. The second most common artery affected is the carotid artery, which is found in the neck and supplies the brain with blood. Less commonly, FMD affects the arteries in the abdomen (supplying the liver, spleen and intestines) and extremities (legs and arms). More than one artery may have evidence of FMD in 28% of people with this disease. All arteries should be checked if FMD is found in one vascular bed.

Diagnosis

Symptoms

Patients are often asymptomatic, but they may complain of the following:

Physical Examination

Neck

Abdomen

Angiography

FMD is often diagnosed incidentally in the absence of any signs or symptoms during an imaging study. Angiography with contrast will show a characteristic "string of beads" morphology in a vessel affected by FMD.

Treatment

ACE inhibitors, and Angiotensin II receptor antagonists are often initial treatments of fibromuscular dysplasia. Refractory cases are often treated by balloon angioplasty or stenting of the renal artery. Besides high blood pressure control, anti-platelet drugs and blood thinner drugs may be used. Bypass surgery is a considered treatment and also vein replacement.

See also


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