Fibromuscular dysplasia

Jump to navigation Jump to search

For patient information page, click here

WikiDoc Resources for Fibromuscular dysplasia

Articles

Most recent articles on Fibromuscular dysplasia

Most cited articles on Fibromuscular dysplasia

Review articles on Fibromuscular dysplasia

Articles on Fibromuscular dysplasia in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Fibromuscular dysplasia

Images of Fibromuscular dysplasia

Photos of Fibromuscular dysplasia

Podcasts & MP3s on Fibromuscular dysplasia

Videos on Fibromuscular dysplasia

Evidence Based Medicine

Cochrane Collaboration on Fibromuscular dysplasia

Bandolier on Fibromuscular dysplasia

TRIP on Fibromuscular dysplasia

Clinical Trials

Ongoing Trials on Fibromuscular dysplasia at Clinical Trials.gov

Trial results on Fibromuscular dysplasia

Clinical Trials on Fibromuscular dysplasia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Fibromuscular dysplasia

NICE Guidance on Fibromuscular dysplasia

NHS PRODIGY Guidance

FDA on Fibromuscular dysplasia

CDC on Fibromuscular dysplasia

Books

Books on Fibromuscular dysplasia

News

Fibromuscular dysplasia in the news

Be alerted to news on Fibromuscular dysplasia

News trends on Fibromuscular dysplasia

Commentary

Blogs on Fibromuscular dysplasia

Definitions

Definitions of Fibromuscular dysplasia

Patient Resources / Community

Patient resources on Fibromuscular dysplasia

Discussion groups on Fibromuscular dysplasia

Patient Handouts on Fibromuscular dysplasia

Directions to Hospitals Treating Fibromuscular dysplasia

Risk calculators and risk factors for Fibromuscular dysplasia

Healthcare Provider Resources

Symptoms of Fibromuscular dysplasia

Causes & Risk Factors for Fibromuscular dysplasia

Diagnostic studies for Fibromuscular dysplasia

Treatment of Fibromuscular dysplasia

Continuing Medical Education (CME)

CME Programs on Fibromuscular dysplasia

International

Fibromuscular dysplasia en Espanol

Fibromuscular dysplasia en Francais

Business

Fibromuscular dysplasia in the Marketplace

Patents on Fibromuscular dysplasia

Experimental / Informatics

List of terms related to Fibromuscular dysplasia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-in-Chief: Shantanu Sinha, MD,FACC

Overview

Fibromuscular dysplasia (FMD) is a disease that can cause stenosis of the renal arteries, carotid arteries, and less commonly, the arteries of the abdomen. The disease can cause hypertension, strokes, and arterial aneurysm and dissection.

In individuals with FMD, the walls of one or more arteries undergo dysplasia. Due to this abnormal cellular development, the vessels may become stenosed. A sufficient decrease in blood flow through the artery can cause symptoms. However, FMD is often diagnosed incidentally in the absence of any signs or symptoms during an imaging study.

Epidemiology and Demographics

Age

Fibromuscular dysplasia tends to occur in females between 14 and 50 years of age. However, it has been found in children under the age of 14.

Sex

Fibromuscular dysplasia affects females more than males.

Pathophysiology

Fibromuscular dysplasia is characterized by fibrous thickening of the intima, media, or adventitia of the renal artery. Up to 75% of all patients with FMD will have disease in the renal arteries (Fenves, 1999). The lesions cause narrowing of the artery lumen. The second most common artery affected is the carotid artery, which is found in the neck and supplies the brain with blood. Less commonly, FMD affects the arteries in the abdomen (supplying the liver, spleen and intestines) and extremities (legs and arms). More than one artery may have evidence of FMD in 28% of people with this disease (Luscher, 1986). All arteries should be checked if found.

Signs and Symptoms

As a result of renal artery stenosis, the kidney's afferent arteriolar pressure falls. The renin-angiotensin system is activated, causing fluid retention and hypertension. Symptoms of craniocervical involvement include headaches and lightheadedness, although patients are often asymptomatic. On physical examination, one may detect neurological symptoms secondary to a stroke, a bruit over an affected artery, and diminished distal pulses.

Angiography

Angiography with contrast will show a characteristic "string of beads" morphology in a vessel affected by FMD.

Treatment

ACE inhibitors, and Angiotensin II receptor antagonists are often initial treatments of fibromuscular dysplasia. Refractory cases are often treated by balloon angioplasty or stenting of the renal artery. Besides high blood pressure control, anti-platelet drugs and blood thinner drugs may be used. Bypass surgery is a considered treatment and also vein replacement.

See also


Template:SIB

de:Fibromuskuläre Dysplasie

Template:WH Template:WS