Fever of unknown origin medical therapy: Difference between revisions
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{ | {{Siren|Fever of unknown origin}} | ||
{{Fever of unknown origin}} | {{Fever of unknown origin}} | ||
{{CMG}} | {{CMG}} | ||
{{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; | {{SK}} febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO | ||
==Overview== | ==Overview== | ||
Since FUO can have variety of etiologies therefore it does not have a standard treatment regimen. However the treatment is usually directed towards the target from potential clues in the History and Physical examination.<ref name="pmid26031980">{{cite journal| author=Mulders-Manders C, Simon A, Bleeker-Rovers C| title=Fever of unknown origin. | journal=Clin Med (Lond) | year= 2015 | volume= 15 | issue= 3 | pages= 280-4 | pmid=26031980 | doi=10.7861/clinmedicine.15-3-280 | pmc=4953114 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26031980 }}</ref><ref name="pmid32462043">{{cite journal| author=Wright WF, Auwaerter PG| title=Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma. | journal=Open Forum Infect Dis | year= 2020 | volume= 7 | issue= 5 | pages= ofaa132 | pmid=32462043 | doi=10.1093/ofid/ofaa132 | pmc=7237822 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=32462043 }}</ref> | |||
==Medical Therapy== | ==Medical Therapy== | ||
=== Empiric antibiotics === | |||
Use of empiric antibiotics should not be encouraged unless the patient is neutropenic or immunocompromised, so that proper workup can be done and a more targeted treatment be given. | |||
=== Steroids === | |||
* Steroids should not be given early as it can mask effects of many diseases. | |||
* however they can be given early in cases of Giant cell temporal arteritis to prevent blindness. | |||
* they are used in rheumatologic causes of FUO. | |||
=== NSAIDS === | |||
Non-steroidal anti-inflammatory drugs are given when no cause is found despite extensive work up. | |||
=== Anakinra === | |||
Interleukin 1 antagonist are give in cases of autoimmune disorders. If no symptomatic improvement occurs after 2 weeks drug should be stopped. | |||
<br /> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Ailments of unknown etiology]] | [[Category:Ailments of unknown etiology]] | ||
Latest revision as of 15:19, 25 January 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: febris continua e causa ignota; febris e causa ignota; febris E.C.I.; fever/pyrexia of obscured/undetermined/uncertain/unidentifiable/unknown focus/origin/source; fever/pyrexia without a focus/origin/source; FUO; PUO
Overview
Since FUO can have variety of etiologies therefore it does not have a standard treatment regimen. However the treatment is usually directed towards the target from potential clues in the History and Physical examination.[1][2]
Medical Therapy
Empiric antibiotics
Use of empiric antibiotics should not be encouraged unless the patient is neutropenic or immunocompromised, so that proper workup can be done and a more targeted treatment be given.
Steroids
- Steroids should not be given early as it can mask effects of many diseases.
- however they can be given early in cases of Giant cell temporal arteritis to prevent blindness.
- they are used in rheumatologic causes of FUO.
NSAIDS
Non-steroidal anti-inflammatory drugs are given when no cause is found despite extensive work up.
Anakinra
Interleukin 1 antagonist are give in cases of autoimmune disorders. If no symptomatic improvement occurs after 2 weeks drug should be stopped.
References
- ↑ Mulders-Manders C, Simon A, Bleeker-Rovers C (2015). "Fever of unknown origin". Clin Med (Lond). 15 (3): 280–4. doi:10.7861/clinmedicine.15-3-280. PMC 4953114. PMID 26031980.
- ↑ Wright WF, Auwaerter PG (2020). "Fever and Fever of Unknown Origin: Review, Recent Advances, and Lingering Dogma". Open Forum Infect Dis. 7 (5): ofaa132. doi:10.1093/ofid/ofaa132. PMC 7237822 Check
|pmc=value (help). PMID 32462043 Check|pmid=value (help).