Diphtheria history and symptoms: Difference between revisions

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==Overview==
==Overview==
[[Respiratory]] [[diphtheria]] presents with a wide range of [[systemic]] and [[respiratory]] symptoms.<ref name="pmid490806">{{cite journal |vauthors=Dobie RA, Tobey DN |title=Clinical features of diphtheria in the respiratory tract |journal=JAMA |volume=242 |issue=20 |pages=2197–201 |year=1979 |pmid=490806 |doi= |url=}}</ref>


==History and Symptoms==
==History and Symptoms==
[[Image:A diphtheria skin lesion on the leg. PHIL 1941 lores.jpg|thumb|left|A diphtheria skin lesion on the leg.]]
[[Respiratory]] [[diphtheria]] presents with a wide range of [[systemic]] and [[respiratory]] symptoms, including:<ref name="pmid490806">{{cite journal |vauthors=Dobie RA, Tobey DN |title=Clinical features of diphtheria in the respiratory tract |journal=JAMA |volume=242 |issue=20 |pages=2197–201 |year=1979 |pmid=490806 |doi= |url=}}</ref>
===Respiratory Symptoms===
*[[Sore throat]] (most common presenting symptom)
*[[Cough]]
*Runny nose ([[rhinorrhea]])
*[[Hoarseness]] of voice
*Nasal obstruction
*Coughing of blood ([[hemoptysis]])


The respiratory form has an [[incubation period]] of 2-5 days. The onset of disease is usually gradual. Symptoms include [[fatigue]], [[fever]], a mild [[sore throat]] and problems swallowing. Children infected have symptoms that include [[nausea]], [[vomiting]], [[chills]], and a high [[fever]], although some do not show symptoms until the infection has progressed further. In 10% of cases, patients experience neck swelling. These cases are associated with a higher risk of death.
===Systemic Symptoms===
*[[Fever]]
*[[Chills]]
*[[Malaise]]
*[[Palpitations]]
*[[Nausea]]
*[[Vomiting]]
*Muscle pain ([[myalgia]])
*Neck swelling due to [[cervical]] [[adenopathy]]


In addition to symptoms at the site of infection ([[sore throat]]), the patient may experience more '''generalized symptoms''', such as listlessness, [[pallor]], and [[fast heart rate]]. These symptoms are caused by the [[toxin]] released by the bacterium. [[Low blood pressure]] may develop in these patients. Longer-term effects of the diphtheria toxin include [[cardiomyopathy]] and [[peripheral neuropathy]] (sensory type).<ref>[http://www.neuro.wustl.edu/neuromuscular/nother/toxic.htm#diphtheria Toxic Neuropathies]. Neuromuscular Disease Center Washington University, St. Louis, MO  USA</ref>
===Cutaneous (Skin) Diphtheria===


The cutaneous form of diphtheria is often a [[secondary infection]] of a preexisting skin disease. Signs of cutaneous diphtheria infection develop an average of seven days after the appearance of the primary skin disease.
[[Image:A diphtheria skin lesion on the leg. PHIL 1941 lores.jpg|thumb|left|A diphtheria skin lesion on the leg. <ref name= "CDC cutaneous">Center for Disease Control and Prevention http://phil.cdc.gov/phil/details.asp​ Accessed on Oct. 7, 2016.</ref>]]
<br clear="left"/>
 
[[Cutaneous]] [[diphtheria]] usually presents with [[ulcers]] or pustular [[lesions]], which can involve different parts of the body. Lesions may be covered by a grayish-white pseudomembrane, similar to tonsillar exudates of [[respiratory]] [[diphtheria]].<ref name="pmid27373251">{{cite journal |vauthors=Rappold LC, Vogelgsang L, Klein S, Bode K, Enk AH, Haenssle HA |title=Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report |journal=J Dtsch Dermatol Ges |volume=14 |issue=7 |pages=734–6 |year=2016 |pmid=27373251 |doi=10.1111/ddg.12722 |url=}}</ref>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 21:23, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

Respiratory diphtheria presents with a wide range of systemic and respiratory symptoms.[1]

History and Symptoms

Respiratory diphtheria presents with a wide range of systemic and respiratory symptoms, including:[1]

Respiratory Symptoms

Systemic Symptoms

Cutaneous (Skin) Diphtheria

A diphtheria skin lesion on the leg. [2]

Cutaneous diphtheria usually presents with ulcers or pustular lesions, which can involve different parts of the body. Lesions may be covered by a grayish-white pseudomembrane, similar to tonsillar exudates of respiratory diphtheria.[3]

References

  1. 1.0 1.1 Dobie RA, Tobey DN (1979). "Clinical features of diphtheria in the respiratory tract". JAMA. 242 (20): 2197–201. PMID 490806.
  2. Center for Disease Control and Prevention http://phil.cdc.gov/phil/details.asp​ Accessed on Oct. 7, 2016.
  3. Rappold LC, Vogelgsang L, Klein S, Bode K, Enk AH, Haenssle HA (2016). "Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report". J Dtsch Dermatol Ges. 14 (7): 734–6. doi:10.1111/ddg.12722. PMID 27373251.



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