Diphtheria history and symptoms: Difference between revisions

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==Overview==
==Overview==
[[Respiratory]] [[diphtheria]] presents with a wide range of [[systemic]] and [[respiratory]] symptoms.<ref name="pmid490806">{{cite journal |vauthors=Dobie RA, Tobey DN |title=Clinical features of diphtheria in the respiratory tract |journal=JAMA |volume=242 |issue=20 |pages=2197–201 |year=1979 |pmid=490806 |doi= |url=}}</ref>
==History and Symptoms==
==History and Symptoms==
[[Respiratory]] [[diphtheria]] presents with a wide range of [[systemic]] and [[respiratory]] symptoms, which include:
[[Respiratory]] [[diphtheria]] presents with a wide range of [[systemic]] and [[respiratory]] symptoms, including:<ref name="pmid490806">{{cite journal |vauthors=Dobie RA, Tobey DN |title=Clinical features of diphtheria in the respiratory tract |journal=JAMA |volume=242 |issue=20 |pages=2197–201 |year=1979 |pmid=490806 |doi= |url=}}</ref>
===Respiratory Symptoms===
===Respiratory Symptoms===
*Sore throat: most common presenting symptom
*[[Sore throat]] (most common presenting symptom)
*[[Cough]]
*[[Cough]]
*Runny nose ([[rhinorrhea]])
*Runny nose ([[rhinorrhea]])
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*Coughing of blood ([[hemoptysis]])
*Coughing of blood ([[hemoptysis]])


===Systemic Sympmtoms===
===Systemic Symptoms===
*[[Fever]]
*[[Fever]]
*[[Chills]]
*[[Chills]]
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*[[Vomiting]]
*[[Vomiting]]
*Muscle pain ([[myalgia]])
*Muscle pain ([[myalgia]])
*Neck swelling due to [[cervical adenopathy]]
*Neck swelling due to [[cervical]] [[adenopathy]]


===Cutaneous (Skin) Diphtheria===
===Cutaneous (Skin) Diphtheria===


[[Image:A diphtheria skin lesion on the leg. PHIL 1941 lores.jpg|thumb|left|A diphtheria skin lesion on the leg.]]
[[Image:A diphtheria skin lesion on the leg. PHIL 1941 lores.jpg|thumb|left|A diphtheria skin lesion on the leg. <ref name= "CDC cutaneous">Center for Disease Control and Prevention http://phil.cdc.gov/phil/details.asp​ Accessed on Oct. 7, 2016.</ref>]]


In the United States, cutaneous diphtheria has been most often associated with homeless persons. Skin infections are quite common in the tropics and are probably responsible for the high levels of natural immunity found in these populations. Skin infections may be manifested by a scaling rash or by ulcers with clearly demarcated edges and membrane, but any chronic skin lesion may harbor C. diphtheriae along with other organisms. Generally, the organisms isolated from recent cases in the United States were nontoxigenic. The severity of the skin disease with toxigenic strains appears to be less than in other forms of infection with toxigenic strains. Skin diseases associated with nontoxigenic strains are no longer reported to the National Notifiable Diseases Surveillance System in the United States.
[[Cutaneous]] [[diphtheria]] usually presents with [[ulcers]] or pustular [[lesions]], which can involve different parts of the body. Lesions may be covered by a grayish-white pseudomembrane, similar to tonsillar exudates of [[respiratory]] [[diphtheria]].<ref name="pmid27373251">{{cite journal |vauthors=Rappold LC, Vogelgsang L, Klein S, Bode K, Enk AH, Haenssle HA |title=Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report |journal=J Dtsch Dermatol Ges |volume=14 |issue=7 |pages=734–6 |year=2016 |pmid=27373251 |doi=10.1111/ddg.12722 |url=}}</ref>
Other sites of involvement include the mucous membranes of the conjunctiva and vulvovaginal area, as well as the external auditory canal.


==References==
==References==
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[[Category:Infectious disease]]




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Latest revision as of 21:23, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dima Nimri, M.D. [2]

Overview

Respiratory diphtheria presents with a wide range of systemic and respiratory symptoms.[1]

History and Symptoms

Respiratory diphtheria presents with a wide range of systemic and respiratory symptoms, including:[1]

Respiratory Symptoms

Systemic Symptoms

Cutaneous (Skin) Diphtheria

A diphtheria skin lesion on the leg. [2]

Cutaneous diphtheria usually presents with ulcers or pustular lesions, which can involve different parts of the body. Lesions may be covered by a grayish-white pseudomembrane, similar to tonsillar exudates of respiratory diphtheria.[3]

References

  1. 1.0 1.1 Dobie RA, Tobey DN (1979). "Clinical features of diphtheria in the respiratory tract". JAMA. 242 (20): 2197–201. PMID 490806.
  2. Center for Disease Control and Prevention http://phil.cdc.gov/phil/details.asp​ Accessed on Oct. 7, 2016.
  3. Rappold LC, Vogelgsang L, Klein S, Bode K, Enk AH, Haenssle HA (2016). "Primary cutaneous diphtheria: management, diagnostic workup, and treatment as exemplified by a rare case report". J Dtsch Dermatol Ges. 14 (7): 734–6. doi:10.1111/ddg.12722. PMID 27373251.



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