Dermoid cyst overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Historical Perspective
The term "dermoid cyst" was first coined by Leblanc, in 1831 following the removal of a lesion that resembled skin at the base of a horse's skull.[1] Dermoid cysts were first clearly described in 1885 by Bytlin. In 1891, Chairi was the first to propose that the tumors in the floor of the mouth originated from the entrapment of epidermoid cells during the embryonic age.[2]
Classification
Dermoid cysts may be classified according to the mode of occurrence into congenital and aquired types and into several subtypes based on the anatomical location.[3][4][5]
Pathophysiology
Dermoid cyst arises from the entrapment of the embryonal ectodermal cells during the fetal development and are generally formed of skin, hair follicles, hair follicles, teeth and sebaceous glands.[6] Acquired dermoid cysts may result from iatrogenic or traumatic implantation of the epithelial cells that subsequently grow.[2][6] On gross pathology, uniloculated cysts lined by skin, containing sebaceous glands, hair follicles, and teeth are characteristic findings of dermoid cysts.[6] On microscopic histopathological analysis, fibro collagenous cysts lined by stratified squamous epithelium, with epidermal appendages such as hair follicles, sweat and sebaceous glands are characteristic findings of dermoid cysts.[7][8]
Differential Diagnosis
Dermoid cyst must be differentiated from teratoma, as well as other common benign tumors that develop in the head and neck, ovaries, or spine (such as pilar cysts, steatocystoma, pilomatrixoma, encephalocele, vascular malformations, lipoleiomyoma, pilonidal cyst, and lipoma).[5][3][8][8][9]
Epidemiology and Demographics
Dermoid cysts are rare benign tumors. Spinal dermoid cysts commonly affect individuals in their second or third decades of life.[8] Males are more commonly affected with spinal dermoid cysts than females.[8] Dermoid cysts in other locations affect men and women equally. There is no racial predilection to the dermoid cysts.
Natural History, complications and Prognosis
The majority of patients with dermoid cysts are asymptomatic. If left untreated, dermoid cysts gradually increase in size and produce symptoms depending upon their anatomical location. Common complications of ovarian dermoid cysts include torsion, rupture, and infection.[10][11] Common complications of periorbital dermoid cysts include inflammation and recurrence when not completely excised.[10] Rupture is the most common complication of spinal dermoid cysts.[10] Common complications of intracranial dermoid cysts include compression of adjacent structures from the mass effect and rupture of the cysts.[12][13] Infection is the most common complication of dermoid cysts of the floor of the mouth.[2] Malignant transformation usually into squamous cell carcinoma is a rare complication of dermoid cysts.[14][11] Depending on the anatomical location of the tumor, the prognosis may vary.
History and Symptoms
Congenital dermoid cysts localized to the scalp, neck or trunk are usually visible at birth and gradually grow in size. The majority of patients with ovarian dermoid cysts are asymptomatic. They are discovered incidentally on routine physical exam or imaging for other reasons.[1] Large ovarian dermoid cysts may present with abdominal pain or abdominal mass.[15] Symptoms of spinal dermoid cyst may include motor disturbances (hemiplegia), sensory disturbances, bowel and/or bladder dysfunction, fecal retention or incontinence, and urinary retention or incontinence. Headache is the most prominent symptom of intracranial dermoid cyst.[16] Symptoms of dermoid cysts of the floor of the mouth may include dysphagia, dysarthria, dyspnea (when the lesions are quiet large), and speech delay.[2]
Physical Examination
Physical examination findings in patients with dermoid cyst may include a painless swelling that may be freely mobile or fixed to the skin and deeper structures. Congenital dermoid cysts localized to the scalp, neck or trunk are usually visible at birth. A tuft of hairs emanating from a midline nasal depression or nodule may represent a nasal dermoid cyst. A tarsal dermoid cyst may present as a firm, non tender nodule in the eyelid. Periorbital demoid cysts usually appear on the lateral aspect of the eyebrow. Dermoid cysts of the scalp or orbit may cause pressure erosion of the underlying bone which appears as a punched out defect in the skull x rays. A double-chin appearance is a common finding if the cyst develops below the mylohyoid muscle.[17][18][18][19][20][2]
X Ray
X rays may be helpful in the diagnosis of dermoid cysts. Findings on pelvic x ray suggestive of ovarian demoid cyst may include calcifications and tooth components.[21] On x-rays, dermoid cysts are characterized by a focal lucency due to the fatty sebum.[22] X rays may appear normal in other dermoid cysts.
CT
- ↑ 1.0 1.1 Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994). "Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature". Obstet Gynecol. 84 (1): 22–8. PMID 8008317.
- ↑ 2.0 2.1 2.2 2.3 2.4 Makos C, Noussios G, Peios M, Gougousis S, Chouridis P (2011). "Dermoid cysts of the floor of the mouth: two case reports". Case Rep Med. 2011: 362170. doi:10.1155/2011/362170. PMC 3172983. PMID 21922020.
- ↑ 3.0 3.1 Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 4, 2016.
- ↑ Spinal dermoid cyst. Radiopedia. http://radiopaedia.org/articles/spinal-dermoid-cyst Accessed on February 10, 2016.
- ↑ 5.0 5.1 Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A; et al. (2012). "A case of sublingual dermoid cyst: extending the limits of the oral approach". Case Rep Otolaryngol. 2012: 634949. doi:10.1155/2012/634949. PMC 3465894. PMID 23056976.
- ↑ 6.0 6.1 6.2 Elsheikh, Tarik (2002), Dermoid Cyst (Mature Cystic Teratoma) of the Cecum, Muncie, IN: Archives of Pathology & Laboratory Medicine, p. 97-99, retrieved February 2, 2016
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 18, 2016.
- ↑ 8.0 8.1 8.2 8.3 8.4 Sharma M, Mally R, Velho V (2013). "Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]". Asian Spine J. 7 (1): 50–4. doi:10.4184/asj.2013.7.1.50. PMC 3596585. PMID 23508636.
- ↑ Intracranial dermoid cyst. Radiopaedia.org. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 5, 2016.
- ↑ 10.0 10.1 10.2 Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 11, 2016
- ↑ 11.0 11.1 Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Radiopedia. Accessed on February 11, 2016
- ↑ Intracranial dermoid cyst. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.
- ↑ Jacquin A, Béjot Y, Hervieu M, Biotti D, Caillier M, Ricolfi FC; et al. (2010). "[Rupture of intracranial dermoid cyst with disseminated lipid droplets]". Rev Neurol (Paris). 166 (4): 451–7. doi:10.1016/j.neurol.2009.09.003. PMID 19846186.
- ↑ Osborn AG, Preece MT (2006). "Intracranial cysts: radiologic-pathologic correlation and imaging approach". Radiology. 239 (3): 650–64. doi:10.1148/radiol.2393050823. PMID 16714456.
- ↑ Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma. Accessed on February 11, 2016.
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.
- ↑ Madke B, Nayak C, Giri A, Jain M (2013). "Nasal dermoid sinus cyst in a young female". Indian Dermatol Online J. 4 (4): 380–1. doi:10.4103/2229-5178.120669. PMC 3853920. PMID 24350035.
- ↑ 18.0 18.1 Koreen IV, Kahana A, Gausas RE, Potter HD, Lemke BN, Elner VM (2009). "Tarsal dermoid cyst: clinical presentation and treatment". Ophthal Plast Reconstr Surg. 25 (2): 146–7. doi:10.1097/IOP.0b013e31819aae6e. PMID 19300165.
- ↑ Dermoid cyst. Wikipedia.https://en.wikipedia.org/wiki/Dermoid_cyst.Accessed on February 22, 2016
- ↑ Maurice SM, Burstein FD (2012). "Disappearing dermoid: fact or fiction?". J Craniofac Surg. 23 (1): e31–3. doi:10.1097/SCS.0b013e3182420981. PMID 22337456.
- ↑ Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Accessed on February 17, 2016.
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 17, 2016.