Delta-like 1: Difference between revisions

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Identifiers
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Orthologs
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Latest revision as of 21:05, 30 August 2017

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.^[1]

Function

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.^[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2^[2]^[3]^[4]

References

↑ ^1.0 ^1.1 "Entrez Gene: DLL1 delta-like 1 (Drosophila)".
↑ Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.
↑ Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302.
↑ Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.

Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004.
Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718.
Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480.
Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256.
Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134.
Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135.
Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood. 95 (5): 1616–25. PMID 10688816.
Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687.
Shimizu K, Chiba S, Saito T, Kumano K, Hirai H (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133.
Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. doi:10.1084/jem.194.7.991. PMC 2193482. PMID 11581320.
Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMC 125840. PMID 11823422.
Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964.
Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162.
Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852.
Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMC 139279. PMID 12482954.
Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. doi:10.3892/ijo.22.5.1073. PMID 12684674.
Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. doi:10.1073/pnas.1230693100. PMC 164639. PMID 12794186.
LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: DLL1 delta-like 1 (Drosophila)".

[pmid11346656-2] Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (July 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. 276 (28): 25753–8. doi:10.1074/jbc.M103473200. PMID 11346656.

[pmid9244302-3] Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S (July 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell. 90 (2): 281–91. doi:10.1016/s0092-8674(00)80336-0. PMID 9244302.

[pmid10958687-4] Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (September 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687.

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[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Delta-like protein 1''' is a [[protein]] that in humans is encoded by the ''DLL1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLL1 delta-like 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Delta-like 1 (Drosophila)
- | HGNCid = 2908
- | Symbol = DLL1
- | AltSymbols =; DELTA1; Delta
- | OMIM = 606582
- | ECnumber =
- | Homologene = 4104
- | MGIid = 104659
- | GeneAtlas_image1 = PBB_GE_DLL1_gnf1h00074_at_tn.png
- | Function = {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0031410 |text = cytoplasmic vesicle}}
- | Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0001709 |text = cell fate determination}} {{GNF_GO|id=GO:0001757 |text = somite specification}} {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0007219 |text = Notch signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007368 |text = determination of left/right symmetry}} {{GNF_GO|id=GO:0007386 |text = compartment specification}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0009912 |text = auditory receptor cell fate commitment}} {{GNF_GO|id=GO:0030097 |text = hemopoiesis}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0030155 |text = regulation of cell adhesion}} {{GNF_GO|id=GO:0042472 |text = inner ear morphogenesis}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0045596 |text = negative regulation of cell differentiation}} {{GNF_GO|id=GO:0045608 |text = negative regulation of auditory receptor cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 28514
-    | Hs_Ensembl = ENSG00000198719
-    | Hs_RefseqProtein = NP_005609
-    | Hs_RefseqmRNA = NM_005618
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 170433219
-    | Hs_GenLoc_end = 170441486
-    | Hs_Uniprot = O00548
-    | Mm_EntrezGene = 13388
-    | Mm_Ensembl = ENSMUSG00000014773
-    | Mm_RefseqmRNA = NM_007865
-    | Mm_RefseqProtein = NP_031891
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 15073094
-    | Mm_GenLoc_end = 15080203
-    | Mm_Uniprot = Q6PFV7
-  }}
-}}
-'''Delta-like 1 (Drosophila)''', also known as '''DLL1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DLL1 delta-like 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family.  It plays a role in mediating cell fate decisions during [[hematopoiesis]]. It may play a role in cell-to-cell communication.<ref name="entrez"/>
-{{PBB_Summary
-| section_title =
-| summary_text = DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family.  It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.<ref name="entrez">{{cite web | title = Entrez Gene: DLL1 delta-like 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+Delta-like 1 has been shown to [[Protein-protein interaction|interact]] with [[NOTCH2]]<ref name = pmid11346656>{{cite journal | vauthors = Shimizu K, Chiba S, Saito T, Kumano K, Takahashi T, Hirai H | title = Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 25753–8 | date = July 2001 | pmid = 11346656 | doi = 10.1074/jbc.M103473200 }}</ref><ref name = pmid9244302>{{cite journal | vauthors = Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S | title = Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane | journal = Cell | volume = 90 | issue = 2 | pages = 281–91 | date = July 1997 | pmid = 9244302 | doi =  10.1016/s0092-8674(00)80336-0}}</ref><ref name = pmid10958687>{{cite journal | vauthors = Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H | title = Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 | journal = Mol. Cell. Biol. | volume = 20 | issue = 18 | pages = 6913–22 | date = September 2000 | pmid = 10958687 | pmc = 88767 | doi =  10.1128/mcb.20.18.6913-6922.2000}}</ref>
+{{Div col end}}
+== References ==
+{{reflist}}
+{{Clear}}
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Watt FM | title = The stem cell compartment in human interfollicular epidermis | journal = J. Dermatol. Sci. | volume = 28 | issue = 3 | pages = 173–80 | year = 2002 | pmid = 11912004 | doi = 10.1016/S0923-1811(02)00003-8 }}
-| citations =
+* {{cite journal | vauthors = Lewis AK, Frantz GD, Carpenter DA, de Sauvage FJ, Gao WQ | title = Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear | journal = Mech. Dev. | volume = 78 | issue = 1–2 | pages = 159–63 | year = 1999 | pmid = 9858718 | doi = 10.1016/S0925-4773(98)00165-8 }}
-*{{cite journal  | author=Watt FM |title=The stem cell compartment in human interfollicular epidermis. |journal=J. Dermatol. Sci. |volume=28 |issue= 3 |pages= 173-80 |year= 2002 |pmid= 11912004 |doi=  }}
+* {{cite journal | vauthors = Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C | title = Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation | journal = Dev. Biol. | volume = 204 | issue = 2 | pages = 420–31 | year = 1999 | pmid = 9882480 | doi = 10.1006/dbio.1998.9092 }}
-*{{cite journal  | author=Lewis AK, Frantz GD, Carpenter DA, ''et al.'' |title=Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear. |journal=Mech. Dev. |volume=78 |issue= 1-2 |pages= 159-63 |year= 1999 |pmid= 9858718 |doi=  }}
+* {{cite journal | vauthors = Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S | title = Human Ligands of the Notch Receptor | journal = Am. J. Pathol. | volume = 154 | issue = 3 | pages = 785–94 | year = 1999 | pmid = 10079256 | pmc = 1866435 | doi = 10.1016/S0002-9440(10)65325-4 }}
-*{{cite journal  | author=Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C |title=Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation. |journal=Dev. Biol. |volume=204 |issue= 2 |pages= 420-31 |year= 1999 |pmid= 9882480 |doi= 10.1006/dbio.1998.9092 }}
+* {{cite journal | vauthors = Beckers J, Clark A, Wünsch K, Hrabé De Angelis M, Gossler A | title = Expression of the mouse Delta1 gene during organogenesis and fetal development | journal = Mech. Dev. | volume = 84 | issue = 1–2 | pages = 165–8 | year = 1999 | pmid = 10473134 | doi = 10.1016/S0925-4773(99)00065-9 }}
-*{{cite journal  | author=Gray GE, Mann RS, Mitsiadis E, ''et al.'' |title=Human ligands of the Notch receptor. |journal=Am. J. Pathol. |volume=154 |issue= 3 |pages= 785-94 |year= 1999 |pmid= 10079256 |doi=  }}
+* {{cite journal | vauthors = Morrison A, Hodgetts C, Gossler A, Hrabé de Angelis M, Lewis J | title = Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear | journal = Mech. Dev. | volume = 84 | issue = 1–2 | pages = 169–72 | year = 1999 | pmid = 10473135 | doi = 10.1016/S0925-4773(99)00066-0 }}
-*{{cite journal  | author=Beckers J, Clark A, Wünsch K, ''et al.'' |title=Expression of the mouse Delta1 gene during organogenesis and fetal development. |journal=Mech. Dev. |volume=84 |issue= 1-2 |pages= 165-8 |year= 1999 |pmid= 10473134 |doi=  }}
+* {{cite journal | vauthors = Han W, Ye Q, Moore MA | title = A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells | journal = Blood | volume = 95 | issue = 5 | pages = 1616–25 | year = 2000 | pmid = 10688816 | doi =  }}
-*{{cite journal  | author=Morrison A, Hodgetts C, Gossler A, ''et al.'' |title=Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear. |journal=Mech. Dev. |volume=84 |issue= 1-2 |pages= 169-72 |year= 1999 |pmid= 10473135 |doi=  }}
+* {{cite journal | vauthors = Shimizu K, Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H | title = Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2 | journal = Mol. Cell. Biol. | volume = 20 | issue = 18 | pages = 6913–22 | year = 2000 | pmid = 10958687 | pmc = 88767 | doi = 10.1128/MCB.20.18.6913-6922.2000 }}
-*{{cite journal  | author=Han W, Ye Q, Moore MA |title=A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. |journal=Blood |volume=95 |issue= 5 |pages= 1616-25 |year= 2000 |pmid= 10688816 |doi=  }}
+* {{cite journal | vauthors = Shimizu K, Chiba S, Saito T, Kumano K, Hirai H | title = Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors | journal = Biochem. Biophys. Res. Commun. | volume = 276 | issue = 1 | pages = 385–9 | year = 2000 | pmid = 11006133 | doi = 10.1006/bbrc.2000.3469 }}
-*{{cite journal  | author=Shimizu K, Chiba S, Hosoya N, ''et al.'' |title=Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6913-22 |year= 2000 |pmid= 10958687 |doi=  }}
+* {{cite journal | vauthors = Jaleco AC, Neves H, Hooijberg E, Gameiro P, Clode N, Haury M, Henrique D, Parreira L | title = Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation | journal = J. Exp. Med. | volume = 194 | issue = 7 | pages = 991–1002 | year = 2001 | pmid = 11581320 | pmc = 2193482 | doi = 10.1084/jem.194.7.991 }}
-*{{cite journal  | author=Shimizu K, Chiba S, Saito T, ''et al.'' |title=Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. |journal=Biochem. Biophys. Res. Commun. |volume=276 |issue= 1 |pages= 385-9 |year= 2000 |pmid= 11006133 |doi= 10.1006/bbrc.2000.3469 }}
+* {{cite journal | vauthors = Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H | title = Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain | journal = EMBO J. | volume = 21 | issue = 3 | pages = 294–302 | year = 2002 | pmid = 11823422 | pmc = 125840 | doi = 10.1093/emboj/21.3.294 }}
-*{{cite journal  | author=Jaleco AC, Neves H, Hooijberg E, ''et al.'' |title=Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. |journal=J. Exp. Med. |volume=194 |issue= 7 |pages= 991-1002 |year= 2001 |pmid= 11581320 |doi=  }}
+* {{cite journal | vauthors = Panin VM, Shao L, Lei L, Moloney DJ, Irvine KD, Haltiwanger RS | title = Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe | journal = J. Biol. Chem. | volume = 277 | issue = 33 | pages = 29945–52 | year = 2002 | pmid = 12036964 | doi = 10.1074/jbc.M204445200 }}
-*{{cite journal  | author=Shimizu K, Chiba S, Saito T, ''et al.'' |title=Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain. |journal=EMBO J. |volume=21 |issue= 3 |pages= 294-302 |year= 2002 |pmid= 11823422 |doi= 10.1093/emboj/21.3.294 }}
+* {{cite journal | vauthors = Sakamoto K, Yamaguchi S, Ando R, Miyawaki A, Kabasawa Y, Takagi M, Li CL, Perbal B, Katsube K | title = The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway | journal = J. Biol. Chem. | volume = 277 | issue = 33 | pages = 29399–405 | year = 2002 | pmid = 12050162 | doi = 10.1074/jbc.M203727200 }}
-*{{cite journal  | author=Panin VM, Shao L, Lei L, ''et al.'' |title=Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29945-52 |year= 2002 |pmid= 12036964 |doi= 10.1074/jbc.M204445200 }}
+* {{cite journal | vauthors = Ohishi K, Varnum-Finney B, Bernstein ID | title = Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells | journal = J. Clin. Invest. | volume = 110 | issue = 8 | pages = 1165–74 | year = 2002 | pmid = 12393852 | pmc = 150801 | doi = 10.1172/JCI16167 }}
-*{{cite journal  | author=Sakamoto K, Yamaguchi S, Ando R, ''et al.'' |title=The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 29399-405 |year= 2002 |pmid= 12050162 |doi= 10.1074/jbc.M203727200 }}
+* {{cite journal | vauthors = Karlström H, Beatus P, Dannaeus K, Chapman G, Lendahl U, Lundkvist J | title = A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 17119–24 | year = 2003 | pmid = 12482954 | pmc = 139279 | doi = 10.1073/pnas.252624099 }}
-*{{cite journal  | author=Ohishi K, Varnum-Finney B, Bernstein ID |title=Delta-1 enhances marrow and thymus repopulating ability of human CD34(+)CD38(-) cord blood cells. |journal=J. Clin. Invest. |volume=110 |issue= 8 |pages= 1165-74 |year= 2002 |pmid= 12393852 |doi=  }}
+* {{cite journal | vauthors = Tohda S, Murata-Ohsawa M, Sakano S, Nara N | title = Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines | journal = Int. J. Oncol. | volume = 22 | issue = 5 | pages = 1073–9 | year = 2003 | pmid = 12684674 | doi = 10.3892/ijo.22.5.1073 }}
-*{{cite journal  | author=Karlström H, Beatus P, Dannaeus K, ''et al.'' |title=A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 17119-24 |year= 2003 |pmid= 12482954 |doi= 10.1073/pnas.252624099 }}
+* {{cite journal | vauthors = Six E, Ndiaye D, Laabi Y, Brou C, Gupta-Rossi N, Israel A, Logeat F | title = The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 13 | pages = 7638–43 | year = 2003 | pmid = 12794186 | pmc = 164639 | doi = 10.1073/pnas.1230693100 }}
-*{{cite journal  | author=Tohda S, Murata-Ohsawa M, Sakano S, Nara N |title=Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines. |journal=Int. J. Oncol. |volume=22 |issue= 5 |pages= 1073-9 |year= 2003 |pmid= 12684674 |doi=  }}
+* {{cite journal | vauthors = LaVoie MJ, Selkoe DJ | title = The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments | journal = J. Biol. Chem. | volume = 278 | issue = 36 | pages = 34427–37 | year = 2003 | pmid = 12826675 | doi = 10.1074/jbc.M302659200 }}
-*{{cite journal  | author=Six E, Ndiaye D, Laabi Y, ''et al.'' |title=The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 13 |pages= 7638-43 |year= 2003 |pmid= 12794186 |doi= 10.1073/pnas.1230693100 }}
-*{{cite journal  | author=LaVoie MJ, Selkoe DJ |title=The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34427-37 |year= 2003 |pmid= 12826675 |doi= 10.1074/jbc.M302659200 }}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
-}}
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-{{protein-stub}}
+{{Notch signaling pathway}}
-{{WikiDoc Sources}}
+{{gene-6-stub}}

v t e Signaling pathway: notch signaling pathway
Receptor on signaling cell	Delta DLL1 DLL3 DLL4
Ligand	Jagged JAG1 JAG2
Receptor on receiving cell	Notch 1 Notch 2 Notch 3 Notch 4

Delta-like 1: Difference between revisions

Latest revision as of 21:05, 30 August 2017

Contents

Function

Interactions

References

Further reading

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