Dalteparin: Difference between revisions

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'''''For patient information, click [[Dalteparin (patient information)|here]]'''''.
{{SB}} Fragmin


==Overview==
==Overview==
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Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.<ref>{{cite journal | author=Douketis J, Cook D, Meade M ''et al.'' | title=Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin | journal=Arch Intern Med | year=2008 | volume=168 | issue=16 | pmid=18779469 | pages=1805–1812 | doi=10.1001/archinte.168.16.1805}}</ref>
Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.<ref>{{cite journal | author=Douketis J, Cook D, Meade M ''et al.'' | title=Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin | journal=Arch Intern Med | year=2008 | volume=168 | issue=16 | pmid=18779469 | pages=1805–1812 | doi=10.1001/archinte.168.16.1805}}</ref>
==Category==
==Category==


Anticoagulants:Heprin group
Anti-coagulant, low molecular weight heparin
==US Brand Names==
 


FRAGMIN<sup>®</sup>
==Prescribing Information==
==FDA Package Insert==


'''| [[Dalteparin indications and usage|Indications and Usage]]'''
===[[Fragmin injection|Fragmin (dalteparin sodium) injection, solution]]===
'''| [[Dalteparin dosage and administration|Dosage and Administration]]'''
'''| [[Dalteparin dosage forms and strengths|Dosage Forms and Strengths]]'''
'''| [[Dalteparin contraindications|Contraindications]]'''
'''| [[Dalteparin warnings and precautions|Warnings and Precautions]]'''
'''| [[Dalteparin adverse reactions|Adverse Reactions]]'''
'''| [[Dalteparin drug interactions|Drug Interactions]]'''
'''| [[Dalteparin use in specific populations|Use in Specific Populations]]'''
'''| [[Dalteparin overdosage|Overdosage]]'''
'''| [[Dalteparin description|Description]]'''
'''| [[Dalteparin clinical pharmacology|Clinical Pharmacology]]'''
'''| [[Dalteparin nonclinical toxicology|Nonclinical Toxicology]]'''
'''| [[Dalteparin clinical studies|Clinical Studies]]'''
'''| [[Dalteparin how supplied storage and handling|How Supplied/Storage and Handling]]'''
'''| [[Dalteparin patient counseling information|Patient Counseling Information]]'''
'''| [[Dalteparin labels and packages|Labels and Packages]]'''
==Mechanism of Action==
Dalteparin is a low molecular weight heparin with antithrombotic properties. It acts by enhancing the inhibition of Factor Xa and thrombin by antithrombin. In humans, dalteparin potentiates preferentially the inhibition of coagulation Factor Xa, while only slightly affecting the activated partial thromboplastin time (APTT).


==References==
==References==


{{Reflist|2}}
{{Reflist|2}}
[[Category:Heprin group]]
[[Category:Anticoagulants]]
[[Category:Cardiovascular Drugs]]
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Revision as of 13:23, 19 March 2014

Dalteparin
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
DrugBank
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KEGG
E number{{#property:P628}}
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]

Synonyms / Brand Names: Fragmin

Overview

Dalteparin is a low molecular weight heparin. It is marketed as Fragmin by Pfizer Inc. Like other low molecular weight heparins, dalteparin is used for prophylaxis or treatment of deep vein thrombosis and pulmonary embolism.

The CLOT study, published in 2003, showed that in patients with malignancy and acute venous thromboembolism, dalteparin was more effective than warfarin in reducing the risk of recurrent embolic events.[1] Dalteparin is not superior to unfractionated heparin in preventing blood clots.[2]

Heparins are cleared by the kidneys, but studies have shown that dalteparin does not accumulate even if kidney function is reduced.[3]

Category

Anti-coagulant, low molecular weight heparin


Prescribing Information

Fragmin (dalteparin sodium) injection, solution

References

  1. ↑ Lee AY, Levine MN, Baker RI, Bowden C, Kakkar AK, Prins M, Rickles FR, Julian JA, Haley S, Kovacs MJ, Gent M (2003). "Low-molecular-weight heparin versus a Coumadin for the prevention of recurrent venous thromboembolism in patients with cancer". N Engl J Med. 349 (2): 146–53. doi:10.1056/NEJMoa025313. PMID 12853587.
  2. ↑ The PROTECT Investigators for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group (2011). "Dalteparin versus unfractionated heparin in critically ill patients". doi:10.1056/NEJMoa1014475.
  3. ↑ Douketis J, Cook D, Meade M; et al. (2008). "Prophylaxis against deep vein thrombosis in critically ill patients with severe renal insufficiency with the low-molecular-weight heparin dalteparin". Arch Intern Med. 168 (16): 1805–1812. doi:10.1001/archinte.168.16.1805. PMID 18779469.
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