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{{ | {{about|Deleted in bladder cancer protein 1|breast cancer|KIAA1967{{!}}Deleted in Breast Cancer 1 (DBC1)|DBC 1 (radio station)|Digital Broadcasting Corporation (Hong Kong)}} | ||
{{Infobox_gene}} | {{Infobox_gene}} | ||
'''Deleted in bladder cancer protein 1''' is a [[protein]] that in humans is encoded by the ''DBC1'' [[gene]].<ref name="pmid9175739">{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum Mol Genet | volume = 6 | issue = 6 | pages = 913–9 |date=Jul 1997 | pmid = 9175739 | pmc = | doi =10.1093/hmg/6.6.913 }}</ref><ref name="pmid10444335">{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=Nov 1999 | pmid = 10444335 | pmc = | doi = 10.1006/geno.1999.5891 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref><ref name=autogenerated1>{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum. Mol. Genet. | volume = 6 | issue = 6 | pages = 913–9 |date=June 1997 | pmid = 9175739 | doi = 10.1093/hmg/6.6.913 | url = }}</ref><ref name=autogenerated2>{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=August 1999 | pmid = 10444335 | doi = 10.1006/geno.1999.5891 | url = }}</ref> | '''Deleted in bladder cancer protein 1''' is a [[protein]] that in humans is encoded by the ''DBC1'' [[gene]].<ref name="pmid9175739">{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum Mol Genet | volume = 6 | issue = 6 | pages = 913–9 |date=Jul 1997 | pmid = 9175739 | pmc = | doi =10.1093/hmg/6.6.913 }}</ref><ref name="pmid10444335">{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=Nov 1999 | pmid = 10444335 | pmc = | doi = 10.1006/geno.1999.5891 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref><ref name=autogenerated1>{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum. Mol. Genet. | volume = 6 | issue = 6 | pages = 913–9 |date=June 1997 | pmid = 9175739 | doi = 10.1093/hmg/6.6.913 | url = }}</ref><ref name=autogenerated2>{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=August 1999 | pmid = 10444335 | doi = 10.1006/geno.1999.5891 | url = }}</ref> | ||
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{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal= | *{{cite journal | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi= |display-authors=etal}} | ||
*{{cite journal | vauthors=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277–88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }} | *{{cite journal | vauthors=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277–88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }} | ||
*{{cite journal | vauthors=Nishiyama H, Takahashi T, Kakehi Y |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171–5 |year= 2000 |pmid= 10469456 |doi=10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B |display-authors=etal}} | *{{cite journal | vauthors=Nishiyama H, Takahashi T, Kakehi Y |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171–5 |year= 2000 |pmid= 10469456 |doi=10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B |display-authors=etal}} | ||
*{{cite journal | vauthors=Nishiyama H, Gill JH, Pitt E |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956–64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 |display-authors=etal}} | *{{cite journal | vauthors=Nishiyama H, Gill JH, Pitt E |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956–64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 |display-authors=etal}} | ||
*{{cite journal | vauthors=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645–9 |year= 2002 |pmid= 12442002 |doi= 10. | *{{cite journal | vauthors=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645–9 |year= 2002 |pmid= 12442002 |doi= 10.1016/s0022-5347(05)64236-x}} | ||
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | *{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}} | ||
*{{cite journal | vauthors=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82–90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }} | *{{cite journal | vauthors=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82–90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }} | ||
*{{cite journal | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}} | *{{cite journal | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}} | ||
*{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | *{{cite journal | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} | ||
*{{cite journal | vauthors=Beetz C, Brodoehl S, Patt S |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335–40 |year= 2005 |pmid= 15643521 |doi= 10.3892/or.13.2.335|display-authors=etal}} | *{{cite journal | vauthors=Beetz C, Brodoehl S, Patt S |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335–40 |year= 2005 |pmid= 15643521 |doi= 10.3892/or.13.2.335|display-authors=etal|doi-broken-date=2018-11-07 }} | ||
*{{cite journal | vauthors=Izumi H, Inoue J, Yokoi S |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997–1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 |display-authors=etal}} | *{{cite journal | vauthors=Izumi H, Inoue J, Yokoi S |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997–1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 |display-authors=etal}} | ||
*{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | *{{cite journal | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}} | ||
Revision as of 13:12, 7 November 2018
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Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[1][2][3][4][5]
This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[3]
The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.
References
- ↑ Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
- ↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
- ↑ 3.0 3.1 "Entrez Gene: DBC1 deleted in bladder cancer 1".
- ↑ Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
- ↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
Further reading
- Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
- Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33". Genomics. 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID 9545632.
- Nishiyama H, Takahashi T, Kakehi Y, et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer". Genes Chromosomes Cancer. 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456.
- Nishiyama H, Gill JH, Pitt E, et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1". Oncogene. 20 (23): 2956–64. doi:10.1038/sj.onc.1204432. PMID 11420708.
- Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors". J. Urol. 168 (6): 2645–9. doi:10.1016/s0022-5347(05)64236-x. PMID 12442002.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells". Oncogene. 23 (1): 82–90. doi:10.1038/sj.onc.1206642. PMID 14712213.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Beetz C, Brodoehl S, Patt S, et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335 (inactive 2018-11-07). PMID 15643521.
- Izumi H, Inoue J, Yokoi S, et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers". Hum. Mol. Genet. 14 (8): 997–1007. doi:10.1093/hmg/ddi092. PMID 15746151.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Louhelainen JP, Hurst CD, Pitt E, et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway". Oncogene. 25 (16): 2409–19. doi:10.1038/sj.onc.1209228. PMID 16369496.
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