DBC1

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[1][2][3][4][5]

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[3]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

  1. Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  2. Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
  3. 3.0 3.1 "Entrez Gene: DBC1 deleted in bladder cancer 1".
  4. Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  5. Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Further reading