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{{about|Deleted in bladder cancer protein 1|breast cancer|KIAA1967{{!}}Deleted in Breast Cancer 1 (DBC1)|DBC 1 (radio station)|Digital Broadcasting Corporation (Hong Kong)}}
{{PBB_Controls
{{Infobox_gene}}
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'''Deleted in bladder cancer protein 1''' is a [[protein]] that in humans is encoded by the ''DBC1'' [[gene]].<ref name="pmid9175739">{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum Mol Genet | volume = 6 | issue = 6 | pages = 913–9 |date=Jul 1997 | pmid = 9175739 | pmc =  | doi =10.1093/hmg/6.6.913  }}</ref><ref name="pmid10444335">{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=Nov 1999 | pmid = 10444335 | pmc =  | doi = 10.1006/geno.1999.5891 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref><ref name=autogenerated1>{{cite journal | vauthors = Habuchi T, Yoshida O, Knowles MA | title = A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC | journal = Hum. Mol. Genet. | volume = 6 | issue = 6 | pages = 913–9 |date=June 1997 | pmid = 9175739 | doi = 10.1093/hmg/6.6.913 | url =  }}</ref><ref name=autogenerated2>{{cite journal | vauthors = Nishiyama H, Hornigold N, Davies AM, Knowles MA | title = A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33 | journal = Genomics | volume = 59 | issue = 3 | pages = 335–8 |date=August 1999 | pmid = 10444335 | doi = 10.1006/geno.1999.5891 | url = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in [[transitional cell carcinoma]] of the bladder.  It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.<ref name="entrez" />
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Deleted in bladder cancer 1
| HGNCid = 2687
| Symbol = DBC1
| AltSymbols =; DBCCR1; FAM5A
| OMIM = 602865
| ECnumber = 
| Homologene = 8754
| MGIid = 1928478
| GeneAtlas_image1 = PBB_GE_DBC1_205818_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008219 |text = cell death}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1620
    | Hs_Ensembl = ENSG00000078725
    | Hs_RefseqProtein = NP_055433
    | Hs_RefseqmRNA = NM_014618
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 120968728
    | Hs_GenLoc_end = 121171566
    | Hs_Uniprot = O60477
    | Mm_EntrezGene = 56710
    | Mm_Ensembl = ENSMUSG00000028351
    | Mm_RefseqmRNA = NM_019967
    | Mm_RefseqProtein = NP_064351
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 68247733
    | Mm_GenLoc_end = 68440758
    | Mm_Uniprot = Q920P3
  }}
}}
'''Deleted in bladder cancer 1''', also known as '''DBC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a [[tumor suppressor gene]].
{{PBB_Summary
| section_title =
| summary_text = This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers.  It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.<ref name="entrez">{{cite web | title = Entrez Gene: DBC1 deleted in bladder cancer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1620| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Auffray C, Behar G, Bois F, ''et al.'' |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263-72 |year= 1995 |pmid= 7757816 |doi=  }}
*{{cite journal  | vauthors=Auffray C, Behar G, Bois F |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=Comptes Rendus de l'Académie des Sciences, Série III |volume=318 |issue= 2 |pages= 263–72 |year= 1995 |pmid= 7757816 |doi=  |display-authors=etal}}
*{{cite journal  | author=Habuchi T, Yoshida O, Knowles MA |title=A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC. |journal=Hum. Mol. Genet. |volume=6 |issue= 6 |pages= 913-9 |year= 1997 |pmid= 9175739 |doi= }}
*{{cite journal  | vauthors=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277–88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }}
*{{cite journal  | author=Habuchi T, Luscombe M, Elder PA, Knowles MA |title=Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. |journal=Genomics |volume=48 |issue= 3 |pages= 277-88 |year= 1998 |pmid= 9545632 |doi= 10.1006/geno.1997.5165 }}
*{{cite journal  | vauthors=Nishiyama H, Takahashi T, Kakehi Y |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171–5 |year= 2000 |pmid= 10469456 |doi=10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B |display-authors=etal}}
*{{cite journal  | author=Nishiyama H, Hornigold N, Davies AM, Knowles MA |title=A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. |journal=Genomics |volume=59 |issue= 3 |pages= 335-8 |year= 1999 |pmid= 10444335 |doi= 10.1006/geno.1999.5891 }}
*{{cite journal  | vauthors=Nishiyama H, Gill JH, Pitt E |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956–64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 |display-authors=etal}}
*{{cite journal  | author=Nishiyama H, Takahashi T, Kakehi Y, ''et al.'' |title=Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer. |journal=Genes Chromosomes Cancer |volume=26 |issue= 2 |pages= 171-5 |year= 2000 |pmid= 10469456 |doi=  }}
*{{cite journal  | vauthors=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645–9 |year= 2002 |pmid= 12442002 |doi= 10.1016/s0022-5347(05)64236-x}}
*{{cite journal  | author=Nishiyama H, Gill JH, Pitt E, ''et al.'' |title=Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. |journal=Oncogene |volume=20 |issue= 23 |pages= 2956-64 |year= 2001 |pmid= 11420708 |doi= 10.1038/sj.onc.1204432 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Wright KO, Messing EM, Reeder JE |title=Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. |journal=J. Urol. |volume=168 |issue= 6 |pages= 2645-9 |year= 2002 |pmid= 12442002 |doi= 10.1097/01.ju.0000037848.19383.88 }}
*{{cite journal  | vauthors=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82–90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Humphray SJ, Oliver K, Hunt AR |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |display-authors=etal}}
*{{cite journal  | author=Wright KO, Messing EM, Reeder JE |title=DBCCR1 mediates death in cultured bladder tumor cells. |journal=Oncogene |volume=23 |issue= 1 |pages= 82-90 |year= 2004 |pmid= 14712213 |doi= 10.1038/sj.onc.1206642 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
*{{cite journal  | vauthors=Beetz C, Brodoehl S, Patt S |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335–40 |year= 2005 |pmid= 15643521 |doi=  10.3892/or.13.2.335|display-authors=etal|doi-broken-date=2018-11-07 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Izumi H, Inoue J, Yokoi S |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997–1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 |display-authors=etal}}
*{{cite journal  | author=Beetz C, Brodoehl S, Patt S, ''et al.'' |title=Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. |journal=Oncol. Rep. |volume=13 |issue= 2 |pages= 335-40 |year= 2005 |pmid= 15643521 |doi=  }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Izumi H, Inoue J, Yokoi S, ''et al.'' |title=Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. |journal=Hum. Mol. Genet. |volume=14 |issue= 8 |pages= 997-1007 |year= 2005 |pmid= 15746151 |doi= 10.1093/hmg/ddi092 }}
*{{cite journal  | vauthors=Louhelainen JP, Hurst CD, Pitt E |title=DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. |journal=Oncogene |volume=25 |issue= 16 |pages= 2409–19 |year= 2006 |pmid= 16369496 |doi= 10.1038/sj.onc.1209228 |display-authors=etal}}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Louhelainen JP, Hurst CD, Pitt E, ''et al.'' |title=DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. |journal=Oncogene |volume=25 |issue= 16 |pages= 2409-19 |year= 2006 |pmid= 16369496 |doi= 10.1038/sj.onc.1209228 }}
}}
}}
{{refend}}
{{refend}}


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{{gene-9-stub}}

Latest revision as of 07:38, 10 January 2019

This article is about Deleted in bladder cancer protein 1. For breast cancer, see Deleted in Breast Cancer 1 (DBC1). For DBC 1 (radio station), see Digital Broadcasting Corporation (Hong Kong).
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.[1][2][3][4][5]

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.[3]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

  1. ↑ Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  2. ↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
  3. ↑ 3.0 3.1 "Entrez Gene: DBC1 deleted in bladder cancer 1".
  4. ↑ Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
  5. ↑ Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics. 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Further reading



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