Cyamemazine: Difference between revisions

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              __NOTOC__
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==Overview==
 
'''Cyamemazine''' ('''Tercian'''), also known as '''cyamepromazine''', is a [[typical antipsychotic]] [[drug]] of the [[phenothiazine]] [[chemical class|class]] which was introduced by [[Theraplix]] in [[France]] in 1972 and later in [[Portugal]] as well.<ref name="urlIndex nominum, international drug ... - Google Books">{{cite book | url = http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA280&dq=cyamemazine%20tercian&as_brr=3&pg=PA280#v=onepage&q=&f=false | title = Index nominum, international drug ... - Google Books | format = | work = | accessdate = }}</ref><ref name="isbn0-412-46630-9">{{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 | page = 534 | isbn = 0-412-46630-9 | oclc = | doi = | url = http://books.google.com/books?id=DeX7jgInYFMC&lpg=RA1-PA534&as_brr=3&pg=RA1-PA534#v=onepage&q=&f=false}}</ref><ref name="urlPharmaceutical manufacturing ... - Google Books">{{cite book | url = http://books.google.com/books?id=X2EyLsG4bcUC&lpg=PA397&dq=cyamemazine%20introduced&as_brr=3&pg=PA397#v=onepage&q=&f=false | title = Pharmaceutical manufacturing ... - Google Books | format = | work = | accessdate = }}</ref><ref name="pmid19393381">{{cite journal | author = Bret P, Bret MC, Queuille E | title = [Prescribing patterns of antipsychotics in 13 French psychiatric hospitals] | language = French | journal = L'Encéphale | volume = 35 | issue = 2 | pages = 129–38 |date=April 2009 | pmid = 19393381 | doi = 10.1016/j.encep.2008.03.007 | url = http://www.masson.fr/masson/S0013-7006(08)00103-6}}</ref> It is used for the treatment of [[schizophrenia]] and, especially, for [[psychosis]]-associated [[anxiety]], due to its unique [[anxiolytic]] efficacy.<ref name="urlStahls Essential Psychopharmacology - Cambridge University Press">{{cite web | url = http://stahlonline.cambridge.org/prescribers_drug.jsf?page=0521683505c20_p115-120.html.therapeutics&name=Cyamemazine | title = Stahl's Essential Psychopharmacology - Cambridge University Press | format = | work = | accessdate = }}</ref><ref name="pmid11423169">{{cite journal | author = Bourin M, Nic Dhonnchadha BA, Claude Colombel M, Dib M, Hascoët M | title = Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice | journal = Behavioural Brain Research | volume = 124 | issue = 1 | pages = 87–95 |date=September 2001 | pmid = 11423169 | doi = 10.1016/S0166-4328(01)00238-8| url = http://linkinghub.elsevier.com/retrieve/pii/S0166432801002388}}</ref>
'''Cyamemazine''' ('''Tercian'''), also known as '''cyamepromazine''', is a [[typical antipsychotic]] [[drug]] of the [[phenothiazine]] [[chemical class|class]] which was introduced by [[Theraplix]] in [[France]] in 1972 and later in [[Portugal]] as well.<ref name="urlIndex nominum, international drug ... - Google Books">{{cite book | url = http://books.google.com/books?id=5GpcTQD_L2oC&lpg=PA280&dq=cyamemazine%20tercian&as_brr=3&pg=PA280#v=onepage&q=&f=false | title = Index nominum, international drug ... - Google Books | format = | work = | accessdate = }}</ref><ref name="isbn0-412-46630-9">{{cite book | author = David J. Triggle | title = Dictionary of Pharmacological Agents | publisher = Chapman & Hall/CRC | location = Boca Raton | year = 1996 | page = 534 | isbn = 0-412-46630-9 | oclc = | doi = | url = http://books.google.com/books?id=DeX7jgInYFMC&lpg=RA1-PA534&as_brr=3&pg=RA1-PA534#v=onepage&q=&f=false}}</ref><ref name="urlPharmaceutical manufacturing ... - Google Books">{{cite book | url = http://books.google.com/books?id=X2EyLsG4bcUC&lpg=PA397&dq=cyamemazine%20introduced&as_brr=3&pg=PA397#v=onepage&q=&f=false | title = Pharmaceutical manufacturing ... - Google Books | format = | work = | accessdate = }}</ref><ref name="pmid19393381">{{cite journal | author = Bret P, Bret MC, Queuille E | title = [Prescribing patterns of antipsychotics in 13 French psychiatric hospitals] | language = French | journal = L'Encéphale | volume = 35 | issue = 2 | pages = 129–38 |date=April 2009 | pmid = 19393381 | doi = 10.1016/j.encep.2008.03.007 | url = http://www.masson.fr/masson/S0013-7006(08)00103-6}}</ref> It is used for the treatment of [[schizophrenia]] and, especially, for [[psychosis]]-associated [[anxiety]], due to its unique [[anxiolytic]] efficacy.<ref name="urlStahls Essential Psychopharmacology - Cambridge University Press">{{cite web | url = http://stahlonline.cambridge.org/prescribers_drug.jsf?page=0521683505c20_p115-120.html.therapeutics&name=Cyamemazine | title = Stahl's Essential Psychopharmacology - Cambridge University Press | format = | work = | accessdate = }}</ref><ref name="pmid11423169">{{cite journal | author = Bourin M, Nic Dhonnchadha BA, Claude Colombel M, Dib M, Hascoët M | title = Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice | journal = Behavioural Brain Research | volume = 124 | issue = 1 | pages = 87–95 |date=September 2001 | pmid = 11423169 | doi = 10.1016/S0166-4328(01)00238-8| url = http://linkinghub.elsevier.com/retrieve/pii/S0166432801002388}}</ref>


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{{Antipsychotics}}
{{Antipsychotics}}
{{Adrenergics}}
 
{{Cholinergics}}
{{Dopaminergics}}
{{Histaminergics}}
{{Serotonergics}}
{{Tricyclics}}


[[Category:Phenothiazines]]
[[Category:Phenothiazines]]
[[Category:Nitriles]]
[[Category:Nitriles]]
 
[[Category:Drug]]
 
{{nervous-system-drug-stub}}

Latest revision as of 19:27, 18 August 2015

Cyamemazine
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AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, IM, IV
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability10-70%
MetabolismHepatic
Elimination half-life10 hours
ExcretionUrine
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC19H21N3S
Molar mass323.46 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Cyamemazine (Tercian), also known as cyamepromazine, is a typical antipsychotic drug of the phenothiazine class which was introduced by Theraplix in France in 1972 and later in Portugal as well.[1][2][3][4] It is used for the treatment of schizophrenia and, especially, for psychosis-associated anxiety, due to its unique anxiolytic efficacy.[5][6]

Cyamemazine differs from other phenothiazine neuroleptics in that aside from the usual profile of dopamine, α1-adrenergic, H1, and mACh receptor antagonism,[7] it additionally produces potent blockade of several serotonin receptors, including 5-HT2A, 5-HT2C, and 5-HT7.[7][8][9][10] These actions have been implicated in cyamemazine's anxiolytic effects (5-HT2C) and lack of extrapyramidal side effects (5-HT2A),[7][8] and despite being classified as a typical, it actually behaves like an atypical antipsychotic.[11]

See also

References

  1. ↑ Index nominum, international drug ... - Google Books.
  2. ↑ David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 534. ISBN 0-412-46630-9.
  3. ↑ Pharmaceutical manufacturing ... - Google Books.
  4. ↑ Bret P, Bret MC, Queuille E (April 2009). "[Prescribing patterns of antipsychotics in 13 French psychiatric hospitals]". L'Encéphale (in French). 35 (2): 129–38. doi:10.1016/j.encep.2008.03.007. PMID 19393381.
  5. ↑ "Stahl's Essential Psychopharmacology - Cambridge University Press".
  6. ↑ Bourin M, Nic Dhonnchadha BA, Claude Colombel M, Dib M, Hascoët M (September 2001). "Cyamemazine as an anxiolytic drug on the elevated plus maze and light/dark paradigm in mice". Behavioural Brain Research. 124 (1): 87–95. doi:10.1016/S0166-4328(01)00238-8. PMID 11423169.
  7. ↑ 7.0 7.1 7.2 Hameg A, Bayle F, Nuss P, Dupuis P, Garay RP, Dib M (February 2003). "Affinity of cyamemazine, an anxiolytic antipsychotic drug, for human recombinant dopamine vs. serotonin receptor subtypes". Biochemical Pharmacology. 65 (3): 435–40. doi:10.1016/S0006-2952(02)01515-0. PMID 12527336.
  8. ↑ 8.0 8.1 Alvarez-Guerra M, d'Alché-Birée F, Wolf WA, Vargas F, Dib M, Garay RP (January 2000). "5-HT3- and 5-HT2C-antagonist properties of cyamemazine: significance for its clinical anxiolytic activity". Psychopharmacology. 147 (4): 412–7. doi:10.1007/s002130050010. PMID 10672635.
  9. ↑ Alvarez-Guerra M, Hameg A, Bayle F, Dib M, Garay RP (November 2002). "5-HT2A receptor antagonist properties of cyamemazine in rat and guinea pig smooth muscle". European Journal of Pharmacology. 454 (2–3): 235–9. doi:10.1016/S0014-2999(02)02489-5. PMID 12421652.
  10. ↑ Benyamina A, Arbus C, Nuss P, Garay RP, Neliat G, Hameg A (January 2008). "Affinity of cyamemazine metabolites for serotonin, histamine and dopamine receptor subtypes". European Journal of Pharmacology. 578 (2–3): 142–7. doi:10.1016/j.ejphar.2007.09.025. PMID 17936750.
  11. ↑ Peinado J, Hameg A, Garay RP, Bayle F, Nuss P, Dib M (February 2003). "Reduction of extracellular dopamine and metabolite concentrations in rat striatum by low doses of acute cyamemazine". Naunyn-Schmiedeberg's Archives of Pharmacology. 367 (2): 134–9. doi:10.1007/s00210-002-0665-4. PMID 12595954.
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