Cowden syndrome natural history, complications and prognosis: Difference between revisions

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===Natural History===
===Natural History===
*The [[symptoms]] of [[cowden syndrome]] usually varies and develops in ranging from 4 to 75 years.<ref name="pmid11455162">{{cite journal |vauthors=Hildenbrand C, Burgdorf WH, Lautenschlager S |title=Cowden syndrome-diagnostic skin signs |journal=Dermatology (Basel) |volume=202 |issue=4 |pages=362–6 |date=2001 |pmid=11455162 |doi=10.1159/000051684 |url=}}</ref>  
*The [[symptoms]] of [[cowden syndrome]] usually tend to develop in second decade of life but varies and develops in ranging from 4 to 75 years.<ref name="pmid11455162">{{cite journal |vauthors=Hildenbrand C, Burgdorf WH, Lautenschlager S |title=Cowden syndrome-diagnostic skin signs |journal=Dermatology (Basel) |volume=202 |issue=4 |pages=362–6 |date=2001 |pmid=11455162 |doi=10.1159/000051684 |url=}}</ref><ref name="pmid3698331">{{cite journal |vauthors=Starink TM, van der Veen JP, Arwert F, de Waal LP, de Lange GG, Gille JJ, Eriksson AW |title=The Cowden syndrome: a clinical and genetic study in 21 patients |journal=Clin. Genet. |volume=29 |issue=3 |pages=222–33 |date=March 1986 |pmid=3698331 |doi= |url=}}</ref>  
*If left untreated, [[patients]] with [[cowden syndrome]] may prone to develop many [[Cancer|cancers]].<ref name="pmid232796352">{{cite journal |vauthors=Baker WD, Soisson AP, Dodson MK |title=Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report |journal=J. Obstet. Gynaecol. Res. |volume=39 |issue=4 |pages=876–8 |date=April 2013 |pmid=23279635 |doi=10.1111/j.1447-0756.2012.02052.x |url=}}</ref>
*If left untreated, [[patients]] with [[cowden syndrome]] may prone to develop many [[Cancer|cancers]].<ref name="pmid232796352">{{cite journal |vauthors=Baker WD, Soisson AP, Dodson MK |title=Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report |journal=J. Obstet. Gynaecol. Res. |volume=39 |issue=4 |pages=876–8 |date=April 2013 |pmid=23279635 |doi=10.1111/j.1447-0756.2012.02052.x |url=}}</ref>



Latest revision as of 13:57, 5 March 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

Overview

Cowden syndrome follows an autosomal dominant pattern of inheritance. If left untreated, patients with cowden syndrome may prone to develop manu cancers.Common complications of cowden syndrome include breast, colon cancer and endometrial cancer. Prognosis is generally ranges from excellent to poor.

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

References

  1. Hildenbrand C, Burgdorf WH, Lautenschlager S (2001). "Cowden syndrome-diagnostic skin signs". Dermatology (Basel). 202 (4): 362–6. doi:10.1159/000051684. PMID 11455162.
  2. Starink TM, van der Veen JP, Arwert F, de Waal LP, de Lange GG, Gille JJ, Eriksson AW (March 1986). "The Cowden syndrome: a clinical and genetic study in 21 patients". Clin. Genet. 29 (3): 222–33. PMID 3698331.
  3. Baker WD, Soisson AP, Dodson MK (April 2013). "Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report". J. Obstet. Gynaecol. Res. 39 (4): 876–8. doi:10.1111/j.1447-0756.2012.02052.x. PMID 23279635.
  4. FitzGerald MG, Marsh DJ, Wahrer D, Bell D, Caron S, Shannon KE, Ishioka C, Isselbacher KJ, Garber JE, Eng C, Haber DA (August 1998). "Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer". Oncogene. 17 (6): 727–31. doi:10.1038/sj.onc.1201984. PMID 9715274.
  5. Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E (November 2013). "Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria". J. Natl. Cancer Inst. 105 (21): 1607–16. doi:10.1093/jnci/djt277. PMID 24136893.
  6. Baker WD, Soisson AP, Dodson MK (April 2013). "Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report". J. Obstet. Gynaecol. Res. 39 (4): 876–8. doi:10.1111/j.1447-0756.2012.02052.x. PMID 23279635.

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