Cowden syndrome natural history, complications and prognosis: Difference between revisions
Jump to navigation
Jump to search
| (9 intermediate revisions by the same user not shown) | |||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
If left untreated, | [[Cowden syndrome]] follows an [[autosomal dominant]] pattern of [[inheritance]]. If left untreated, patients with [[cowden syndrome]] may prone to develop manu [[cancers]].Common [[complications]] of [[cowden syndrome]] include [[breast]], [[colon]] [[cancer]] and [[endometrial cancer]]. [[Prognosis]] is generally ranges from excellent to poor. | ||
Common complications of [ | |||
Prognosis is generally excellent | |||
==Natural History, Complications, and Prognosis== | ==Natural History, Complications, and Prognosis== | ||
===Natural History=== | ===Natural History=== | ||
*The symptoms of [[cowden syndrome]] usually varies and develops in ranging from | *The [[symptoms]] of [[cowden syndrome]] usually tend to develop in second decade of life but varies and develops in ranging from 4 to 75 years.<ref name="pmid11455162">{{cite journal |vauthors=Hildenbrand C, Burgdorf WH, Lautenschlager S |title=Cowden syndrome-diagnostic skin signs |journal=Dermatology (Basel) |volume=202 |issue=4 |pages=362–6 |date=2001 |pmid=11455162 |doi=10.1159/000051684 |url=}}</ref><ref name="pmid3698331">{{cite journal |vauthors=Starink TM, van der Veen JP, Arwert F, de Waal LP, de Lange GG, Gille JJ, Eriksson AW |title=The Cowden syndrome: a clinical and genetic study in 21 patients |journal=Clin. Genet. |volume=29 |issue=3 |pages=222–33 |date=March 1986 |pmid=3698331 |doi= |url=}}</ref> | ||
*If left untreated, [[patients]] with [[cowden syndrome]] may prone to develop many [[Cancer|cancers]].<ref name="pmid232796352">{{cite journal |vauthors=Baker WD, Soisson AP, Dodson MK |title=Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report |journal=J. Obstet. Gynaecol. Res. |volume=39 |issue=4 |pages=876–8 |date=April 2013 |pmid=23279635 |doi=10.1111/j.1447-0756.2012.02052.x |url=}}</ref> | |||
*If left untreated, [ | |||
===Complications=== | ===Complications=== | ||
*Common complications of [ | *Common [[complications]] of [[cowden syndrome]] include:<ref name="pmid9715274">{{cite journal |vauthors=FitzGerald MG, Marsh DJ, Wahrer D, Bell D, Caron S, Shannon KE, Ishioka C, Isselbacher KJ, Garber JE, Eng C, Haber DA |title=Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer |journal=Oncogene |volume=17 |issue=6 |pages=727–31 |date=August 1998 |pmid=9715274 |doi=10.1038/sj.onc.1201984 |url=}}</ref><ref name="pmid24136893">{{cite journal |vauthors=Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E |title=Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria |journal=J. Natl. Cancer Inst. |volume=105 |issue=21 |pages=1607–16 |date=November 2013 |pmid=24136893 |doi=10.1093/jnci/djt277 |url=}}</ref><ref name="pmid23279635">{{cite journal |vauthors=Baker WD, Soisson AP, Dodson MK |title=Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report |journal=J. Obstet. Gynaecol. Res. |volume=39 |issue=4 |pages=876–8 |date=April 2013 |pmid=23279635 |doi=10.1111/j.1447-0756.2012.02052.x |url=}}</ref> | ||
**[ | **[[Breast cancer]] | ||
**[ | **[[Colon cancer]] | ||
**[ | **[[Endometrial cancer]] | ||
**[[Bladder cancer]] ([[transitional cell carcinoma]]) | |||
**[[Renal cell carcinoma]] | |||
**[[Non-Hodgkin lymphoma]] | |||
**[[Acute myelogenous leukemia]] | |||
**[[Osteosarcoma]] | |||
===Prognosis=== | ===Prognosis=== | ||
Latest revision as of 13:57, 5 March 2019
|
Cowden syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Cowden syndrome natural history, complications and prognosis On the Web |
|
American Roentgen Ray Society Images of Cowden syndrome natural history, complications and prognosis |
|
FDA on Cowden syndrome natural history, complications and prognosis |
|
CDC on Cowden syndrome natural history, complications and prognosis |
|
Cowden syndrome natural history, complications and prognosis in the news |
|
Blogs on Cowden syndrome natural history, complications and prognosis |
|
Risk calculators and risk factors for Cowden syndrome natural history, complications and prognosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
Cowden syndrome follows an autosomal dominant pattern of inheritance. If left untreated, patients with cowden syndrome may prone to develop manu cancers.Common complications of cowden syndrome include breast, colon cancer and endometrial cancer. Prognosis is generally ranges from excellent to poor.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of cowden syndrome usually tend to develop in second decade of life but varies and develops in ranging from 4 to 75 years.[1][2]
- If left untreated, patients with cowden syndrome may prone to develop many cancers.[3]
Complications
- Common complications of cowden syndrome include:[4][5][6]
Prognosis
- Prognosis is generally ranges from excellent to poor, and the mortality rate of patients with cowden syndrome is based on malignant tumors associated with it.
- The presence of benign tumours is associated with a particularly poor prognosis among patients with cowden syndrome.
References
- ↑ Hildenbrand C, Burgdorf WH, Lautenschlager S (2001). "Cowden syndrome-diagnostic skin signs". Dermatology (Basel). 202 (4): 362–6. doi:10.1159/000051684. PMID 11455162.
- ↑ Starink TM, van der Veen JP, Arwert F, de Waal LP, de Lange GG, Gille JJ, Eriksson AW (March 1986). "The Cowden syndrome: a clinical and genetic study in 21 patients". Clin. Genet. 29 (3): 222–33. PMID 3698331.
- ↑ Baker WD, Soisson AP, Dodson MK (April 2013). "Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report". J. Obstet. Gynaecol. Res. 39 (4): 876–8. doi:10.1111/j.1447-0756.2012.02052.x. PMID 23279635.
- ↑ FitzGerald MG, Marsh DJ, Wahrer D, Bell D, Caron S, Shannon KE, Ishioka C, Isselbacher KJ, Garber JE, Eng C, Haber DA (August 1998). "Germline mutations in PTEN are an infrequent cause of genetic predisposition to breast cancer". Oncogene. 17 (6): 727–31. doi:10.1038/sj.onc.1201984. PMID 9715274.
- ↑ Pilarski R, Burt R, Kohlman W, Pho L, Shannon KM, Swisher E (November 2013). "Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria". J. Natl. Cancer Inst. 105 (21): 1607–16. doi:10.1093/jnci/djt277. PMID 24136893.
- ↑ Baker WD, Soisson AP, Dodson MK (April 2013). "Endometrial cancer in a 14-year-old girl with Cowden syndrome: a case report". J. Obstet. Gynaecol. Res. 39 (4): 876–8. doi:10.1111/j.1447-0756.2012.02052.x. PMID 23279635.