Clubbing causes: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Bot: Automated text replacement (-{{columns-list|3| +{{columns-list|))
 
(44 intermediate revisions by one other user not shown)
Line 4: Line 4:


==Overview==
==Overview==
Life threatening causes of clubbing include [[lung cancer]], [[tetralogy of fallot]], [[transposition of great vessels]], and [[tricuspid atresia]]. Other common causes of clubbing are [[bronchiectasis]], [[cystic fibrosis]],  [[cirrhosis]], and  [[empyema]].
==Causes==
==Causes==
===Life Threatening Causes===
===Life Threatening Causes===
*[[Aneurysm]]
*[[Lung cancer]]
*[[Tetralogy of Fallot]]
*[[Transposition of the great vessels]]
*[[Tricuspid atresia]]
*[[Truncus arteriosus]]


===Common Causes===
===Common Causes===
 
*[[Bronchiectasis]]
*[[Cystic fibrosis]]
*[[Celiac disease]]
*[[Cirrhosis]]
*[[Empyema]]
*[[Graves disease]]
*[[Lung abscess]]


=== Causes by Organ System ===
=== Causes by Organ System ===
{|style="width: 80%; height: 100px; text-align: justify; text-justify: distribute;" border="1"
{|style="width: 80%; height: 100px; text-align: justify; text-justify: distribute;" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Congenital heart disease cyanotic|Cyanotic congenital heart disease]], [[Right-to-left shunt|Right-to-left shunting]], [[Bacterial endocarditis]], [[Tetralogy of fallot]], [[Total anomalous pulmonary venous connection]], [[Transposition of the great vessels]], [[Tricuspid atresia]], [[Truncus arteriosus]], [[Arteriovenous malformation]]s , [[Arterial vascular prosthesis infections]], [[Atrial myxoma]], [[Pulmonic stenosis]]  
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[ Aneurysm]], [[arterial vascular prosthesis infections]], [[arteriovenous fistula]], [[arteriovenous malformations]], [[atrial myxoma]], [[atrial septal defect]], [[cerebrovascular insult]], [[hypoxia|chronic hypoxia]], [[common ventricle]], [[Congenital heart disease|congenital cardiovascular malformations]], [[congestive heart failure]],  [[Congenital heart disease cyanotic|cyanotic congenital heart disease]], [[Congenital heart disease|conotruncal heart malformations]], [[double outlet right ventricle]], [[Eisenmenger syndrome]], [[endocarditis]], [[ erythromelalgia ]], [[patent ductus arteriosus]], [[Pulmonary hypertension|pulmonary thromboembolic hypertension]], [[Right-to-left shunt|right-to-left shunting]], [[subacute bacterial endocarditis]], [[Taussig-Bing syndrome]], [[tetralogy of fallot]], [[total anomalous pulmonary venous connection]], [[transposition of the great vessels]], [[tricuspid atresia]], [[truncus arteriosus]], [[pulmonic stenosis]], [[heart cancer]], [[ventricular septal defect]].
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
| '''Chemical / poisoning'''
|bgcolor="Beige"| [[Cannabis]], [[Lipoid pneumonia]],
|bgcolor="Beige"| [[Ammonia|Ammonia inhalation]], [[chlorine|chlorine inhalation]], [[Diacetyl|diacetyl inhalation]], [[Hydrogen bromide |hydrogen bromide inhalation]], [[Hydrogen chloride |hydrogen chloride inhalation]], [[Hydrogen fluoride |hydrogen fluoride inhalation]], [[Hydrogen sulfide |hydrogen sulfide inhalation]], [[Methyl isocyanate |methyl isocyanate inhalation]], [[Nitrogen oxide |nitrogen oxide inhalation]], [[Ozone|Ozone inhalation]], [[Phosgene|phosgene inhalation]], [[Polyamide|polyamide-amine dyes inhalation]], [[Sulfur dioxide |sulfur dioxide inhalation]], [[Thionyl chloride |thionyl chloride inhalation]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Hereditary haemorrhagic telangiectasia]], [[hidrotic ectodermal dysplasia]], Shell nail syndrome
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Cannabis]], [[Interferon gamma]]
|bgcolor="Beige"| [[Cannabis]], [[dexfenfluramine]], [[fenfluramine]], [[Interferon gamma]], [[Senna]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| [[Nasopharyngeal carcinoma]]
|bgcolor="Beige"| [[Hereditary hemorrhagic telangiectasia]], [[nasopharyngeal carcinoma]]
|-  
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| [[Thyroid cancer]], [[Thyrotoxicosis]]
|bgcolor="Beige"| [[Graves disease]], [[Thyroid cancer]], [[Thyrotoxicosis]], [[POEMS syndrome]]
 
|-  
|-  
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"| [[Mesothelioma]], [[Silicosis]]
|bgcolor="Beige"| [[Mesothelioma]], [[silicosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Ulcerative colitis]], [[Crohn disease]], [[Primary biliary cirrhosis]], [[Cirrhosis]] of the liver, [[Leiomyoma]] of the esophagus, [[Achalasia]], and [[Peptic ulcer]] of the esophagus, [[Celiac sprue]], [[Hepatoma]]
|bgcolor="Beige"| [[Achalasia]],[[celiac sprue]], [[chronic liver disease]], [[obstructive jaundice |chronic obstructive jaundice]], [[Cirrhosis|cirrhosis of  liver]], [[Crohn disease]], [[cystic fibrosis]], [[Gastrointestinal cancer|gastrointestinal neoplasms]], [[hepatoma]], [[hepatopulmonary syndrome]], [[Inflammatory bowel disease]], [[Leiomyoma|leiomyoma of the esophagus]], [[Liver Cancer |liver tumors]], [[malabsorption]], [[oesophageal cancer]], [[Peutz-Jeghers syndrome]], [[primary biliary cirrhosis]], [[small bowel lymphoma]], [[stomach cancer]], [[ulcerative colitis]], [[Whipple disease]]  
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Cystic fibrosis]]
|bgcolor="Beige|[[Celiac disease]],  [[crohn's disease]], [[Cystic fibrosis]], [[Situs inversus |dextrocardia-bronchiectasis-sinusitis]], [[Ebstein's anomaly]], [[Eisenmenger syndrome]],  [[Peutz-Jeghers Syndrome]], [[Taussig-Bing syndrome ]], [[hereditary haemorrhagic telangiectasia]], [[Ivemark syndrome]], [[Jansen's metaphyseal chondrodysplasia ]], [[pachydermoperiostosis]]  
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| [[Myelofibrosis]]
|bgcolor="Beige"| [[Hodgkin lymphoma]], [[Myelofibrosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| [[Cannabis]]
|bgcolor="Beige"|No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| [[Tuberculosis]], [[Empyema]]
|bgcolor="Beige"| [[Aspergillosis]], [[empyema]], [[Infective endocarditis]], [[lymphadenitis]], [[pulmonary abscess]], [[pulmonary tuberculosis]], [[subacute bacterial endocarditis]], [[tuberculosis]],
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
| '''Musculoskeletal / Ortho'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Jansen's metaphyseal chondrodysplasia]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| [[Cerebrovascular insult]]
|bgcolor="Beige"| [[Cerebrovascular insult]], [[hereditary hemorrhagic telangiectasia]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
| '''Nutritional / Metabolic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Celiac sprue]], [[cystic fibrosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 78: Line 92:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| [[Thyroid cancer]], [[Thymus cancer]], [[Hodgkin's disease]], [[POEMS syndrome]], [[Metastatic]] [[melanoma]], [[Mesothelioma]], [[Nasopharyngeal carcinoma]], [[Myelofibrosis]], [[Atrial myxoma]],   
|bgcolor="Beige"| [[Atrial myxoma]], [[bronchial carcinoma]], [[Hodgkin's disease]], [[lung cancer]], [[mesothelioma]], [[melanoma|metastatic  melanoma]], [[myelofibrosis ]], [[nasopharyngeal carcinoma]], [[pancoast tumor]], [[pleural fibroma]], [[pleural mesothelioma]],[[POEMS syndrome]], [[Stomach cancer]]
|-
[[thyroid cancer]], [[thymus cancer]]
  |-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Opthalmologic'''
| '''Opthalmologic'''
Line 86: Line 101:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
| '''Overdose / Toxicity'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Cannabis]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 94: Line 109:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| [[Lung cancer]], [[Cystic fibrosis]], [[Interstitial lung disease]], [[Idiopathic pulmonary fibrosis]], [[Sarcoidosis]],[[Lipoid pneumonia]], [[Empyema]], [[Pleural mesothelioma]], [[Pulmonary artery sarcoma]], [[Cryptogenic fibrosing alveolitis]], [[Pulmonary metastasis]], [[Bronchiectasis]]  
|bgcolor="Beige"|[[Asbestosis]], [[Asthma|asthma complicated by infection]], [[berylliosis]],[[bronchial carcinoma]],[[bronchiectasis]], [[bronchiolitis obliterans]], [[bronchogenic carcinoma]], [[hypoxia|chronic hypoxia]],[[chronic obstructive pulmonary disease ]],[[cryptogenic fibrosing alveolitis]],[[cystic fibrosis]], [[emphysema]],[[empyema]],[[extrathoracic disease]], [[extrinsic allergic alveolitis]], [[Interstitial fibrosis |familial interstitial fibrosis]], [[pulmonary arterial hypertension |familial pulmonary arterial hypertension]], [[fibrosing alveolitis]], [[Hamman-Rich Syndrome ]], [[hepatopulmonary syndrome]], [[hypersensitivity pneumonitis]],[[hypertrophic pulmonary osteoarthropathy]], [[Diffuse interstitial fibrosis|idiopathic diffuse interstitial fibrosis]], [[idiopathic pulmonary fibrosis]], [[idiopathic pulmonary haemosiderosis]], [[idiopathic pulmonary hypertension ]], [[interstitial fibrosis]], [[interstitial lung disease]],[[interstitial pneumonitis]], [[lipoid pneumonia]],[[lung cancer]], [[Hypertrophic osteoarthropathy|Marie-bamberg syndrome]],[[pancoast tumor]], [[pleural fibroma]], [[pleural mesothelioma]],[[polyarteritis nodosa]],[[primary pulmonary hypertension]], [[pulmonary abscess]], [[pulmonary alveolar proteinosis]], [[pulmonary arteriovenous malformation]], [[pulmonary artery sarcoma]],[[pulmonary artery sclerosis]], [[pulmonary fibrosis]], [[Granuloma|pulmonary granuloma]], [[pulmonary hypertension]], [[Lymphoma|pulmonary lymphoma]], [[pulmonary metastases]], [[Pulmonary surfactant-associated protein B|pulmonary surfactant protein b, deficiency]], [[Pulmonary hypertension|pulmonary thromboembolic hypertension]], [[pulmonary tuberculosis]], [[pulmonic stenosis]], [[sarcoidosis]], [[Secondary pulmonary hypertension]], [[silicosis]], [[Pulmonary surfactant|surfactant metabolism dysfunction]].
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Renal / Electrolyte'''
| '''Renal / Electrolyte'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Polyarteritis nodosa]]
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy'''
| '''Rheum / Immune / Allergy'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Alpha heavy chain disease]], [[celiac sprue]], [[crohn's disease]], [[Fischer syndrome]], [[Graves disease]], [[Kindler syndrome|Kindler-weary bullous acrokeratotic poikiloderma]], [[lymphoid interstitial pneumonia]], [[polyarteritis nodosa]], [[sarcoidosis]].
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
Line 118: Line 133:
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| [[Sarcoidosis]]
|bgcolor="Beige"| Bindewald-ulmer-muller syndrome
|-
|-
|}
|}


===Causes in Alphabetical Order===
===Causes in Alphabetical Order===
* [[Achalasia]]
{{columns-list|
* [[Arteriovenous malformation]]s
 
* [[Arteriovenous shunts]]
*[[Aneurysm]]
* [[Arterial vascular prosthesis infections]] <ref name="pmid16721260">{{cite journal |author=Alonso-Bartolomé P, Martínez-Taboada VM, Pina T, Blanco R, Rodriguez-Valverde V |title=Hypertrophic osteoarthropathy secondary to vascular prosthesis infection: report of 3 cases and review of the literature |journal=Medicine (Baltimore) |volume=85 |issue=3 |pages=183–91 |year=2006 |month=May |pmid=16721260 |doi=10.1097/01.md.0000224714.27508.8b |url=}}</ref>
*[[Erythromelalgia ]]
* [[Atrial myxoma]]
*[[Achalasia]]
* [[Biliary cirrhosis]]
*[[Alpha heavy chain disease]]
* [[Bronchial carcinoma]]<ref>Sridhar KS, Lobo CF, Altman RD. Digital clubbing and lung cancer. ''Chest'' 1998;114:1535-37. PMID 9872183</ref>
*[[Ammonia |Ammonia inhalation]]
* [[Bronchiectasis]]
*[[Arterial vascular prosthesis infections ]]  
* [[Cannabis]] <ref name="pmid18238953">{{cite journal |author=Schuller A, Cottin V, Hot A, Cordier JF |title=Finger clubbing and altered carbon monoxide transfer capacity in cannabis smokers |journal=Eur. Respir. J. |volume=31 |issue=2 |pages=473–4 |year=2008 |month=February |pmid=18238953 |doi=10.1183/09031936.00150907 |url=}}</ref>
*[[Arteriovenous fistula]]
* [[Celiac Sprue]]<ref name="pmid16238129">{{cite journal |author=Gajewska J, Ambroszkiewicz J, Hozyasz KK |title=[The impairement of bone formation and resorption in 25-year-old man with neglected celiac disease] |language=Polish |journal=Wiad. Lek. |volume=58 |issue=5-6 |pages=338–41 |year=2005 |pmid=16238129 |doi= |url=}}</ref>
*[[Arteriovenous malformations]]
* [[Cerebrovascular insult]]
*[[Arteriovenous shunts]]
* Chronic obstructive [[jaundice]]
*[[Asbestosis]]
* [[Cirrhosis]]
*[[Aspergillosis]]
* [[Crohn's disease]]
*[[Asthma|Asthma complicated by infection]]
* [[Cyanotic congenital heart disease]]<ref name="pmid3909407">{{cite journal |author=Pineda CJ, Guerra J, Weisman MH, Resnick D, Martinez-Lavin M |title=The skeletal manifestations of clubbing: a study in patients with cyanotic congenital heart disease and hypertrophic osteoarthropathy |journal=Semin. Arthritis Rheum. |volume=14 |issue=4 |pages=263–73 |year=1985 |month=May |pmid=3909407 |doi= |url=}}</ref>
*[[Atrial myxoma]]
**[[Tetralogy of Fallot]]  
*[[Atrial septal defect]]
**[[Total anomalous venous connection]]  
*[[Berylliosis]]  
**[[Transposition of the great vessels]]  
*[[Biliary cirrhosis]]
**[[Tricuspid atresia]]  
*[[Bindewald-ulmer-muller syndrome]]
**[[Truncus arteriosus]]  
*[[Bronchial carcinoma]]  
* [[Cystic Fibrosis]]<ref name="pmid16504602">{{cite journal |author=Van Ginderdeuren F, Van Cauwelaert K, Malfroot A |title=Influence of digital clubbing on oxygen saturation measurements by pulse-oximetry in cystic fibrosis patients |journal=J. Cyst. Fibros. |volume=5 |issue=2 |pages=125–8 |year=2006 |month=May |pmid=16504602 |doi=10.1016/j.jcf.2006.01.007 |url=}}</ref>
*[[Bronchiectasis]]
* [[Endocarditis]]<ref name="pmid18843516">{{cite journal |author=Ozdemir B, Sentürk T, Kaderli AA, ''et al.'' |title=Postoperative regression of clubbing at an unexpected rate in a patient with aortic and mitral valve replacement due to infective endocarditis |journal=Ir J Med Sci |volume= |issue= |pages= |year=2008 |month=October |pmid=18843516 |doi=10.1007/s11845-008-0231-2 |url=}}</ref>
*[[Bronchiolitis obliterans ]]
* [[Empyema]]
*[[Bronchogenic carcinoma]]
* [[Emphysema]]
*[[Cannabis]]
* [[Heart failure]]
*[[Cardiac tumor]]
* [[Hepatoma]]
*[[Celiac sprue]]  
* [[Hodgkin's lymphoma]]<ref name="pmid5553121">{{cite journal |author=Mullins GM, Lenhard RE |title=Digital clubbing in Hodgkin's disease |journal=Johns Hopkins Med J |volume=128 |issue=3 |pages=153–7 |year=1971 |month=March |pmid=5553121 |doi= |url=}}</ref>
*[[Cerebrovascular insult]]
*[[Chlorine|Chlorine inhalation]]
*[[hypoxia|Chronic hypoxia]]
*[[Chronic liver disease]]
*[[Obstructive jaundice |Chronic obstructive jaundice]]
*[[Chronic obstructive pulmonary disease]]
*[[Cirrhosis]]
*[[Celiac disease]]  
*[[Common ventricle]]
*[[tuberculosis|Complicated tuberculosis]]
*[[Congenital]]
*[[Arteriovenous shunts|Congenital arteriovenous shunt]]
*[[Congenital heart disease|Congenital cardiovascular malformations]]
*[[Congenital heart defects ]]
*[[Cyanotic heart disease|Congenital cyanotic heart disease]]
*[[Congestive heart failure]]
*[[Congenital heart disease|Conotruncal heart malformations]]
*[[Cranio osteoarthropathy]]
*[[Crohn's disease]]
*[[Cryptogenic fibrosing alveolitis]]
*[[Cystic fibrosis]]
*[[Deafness ]]
*[[Dexfenfluramine]]
*[[Situs inversus |Dextrocardia-bronchiectasis-sinusitis]]
*[[Diacetyl|Diacetyl inhalation]]
*[[Double outlet right ventricle]]
*[[Ebstein's anomaly]]
*[[Eisenmenger syndrome]]  
*[[Emphysema]]
*[[Endocarditis]]  
*[[Esophageal achalasia]]
*[[Extrathoracic disease]]
*[[Extrinsic allergic alveolitis]]
*[[Tetralogy of Fallot |Fallot syndrome]]
*[[Interstitial fibrosis |Familial interstitial fibrosis]]
*[[pulmonary arterial hypertension |Familial pulmonary arterial hypertension]]
*[[Fenfluramine]]
*[[Fibrosing alveolitis]]
*[[Fischer syndrome]]
*[[Gastrointestinal cancer|Gastrointestinal neoplasms]]
*[[Graves disease]]
*[[Hereditary haemorrhagic telangiectasia |Haemorrhagic telangiectasia]]
*[[Hamman-Rich Syndrome ]]
*[[Hepatoma]]
*[[Hepatopulmonary syndrome]]
*[[Hereditary haemorrhagic telangiectasia]]  
*[[Hidrotic ectodermal dysplasia]]  
*[[Hodgkin lymphoma]]  
*[[Hydrogen bromide |Hydrogen bromide inhalation]]
*[[Hydrogen chloride |Hydrogen chloride inhalation]]
*[[Hydrogen fluoride |Hydrogen fluoride inhalation]]
*[[Hydrogen sulfide |Hydrogen sulfide inhalation]]
*[[Hypersensitivity pneumonitis]]
*[[Hypertrophic pulmonary osteoarthropathy]]
*[[Diffuse interstitial fibrosis|Idiopathic diffuse interstitial fibrosis]]
*[[Idiopathic pulmonary fibrosis]]
*[[Idiopathic pulmonary haemosiderosis]]
*[[Idiopathic pulmonary hypertension]]
*[[Infective endocarditis]]
*[[Inflammatory bowel disease]]
*[[Interferon gamma]]
*[[Interferon gamma]]
*[[Interstitial lung disease]]
*[[Interstitial pneumonitis]]
*[[Interstitial lung disease |Interstitial pulmonary fibrosis]]
*[[Ivemark syndrome]]
*[[Jansen's metaphyseal chondrodysplasia ]]
*[[Kindler syndrome|Kindler-weary bullous acrokeratotic poikiloderma]]
*[[Liver Cancer |Liver tumors]]
*[[Lung abscess]]
*[[Lung cancer]]
*[[Lymphadenitis]]
*[[Lymphoid interstitial pneumonia]]
*[[Malabsorption]]
*[[Hypertrophic osteoarthropathy|Marie-bamberg syndrome]]
*[[Mesothelioma]]
*[[Mesothelioma of the pleura]]
*[[Metastatic melanoma]]
*[[Methyl isocyanate |Methyl isocyanate inhalation]]
*[[Mycobacterium tuberculosis]]
*[[Myelofibrosis]]
*[[Myxomas]]
*[[Nasopharyngeal carcinoma]]
*[[Nitrogen oxide |Nitrogen oxide inhalation]]
*[[Oesophageal cancer]]
*[[Overactive thyroid gland]]
*[[Ozone|Ozone inhalation]]
*[[Pachydermoperiostosis]]
*[[Pancoast tumor ]]
*[[Patent ductus arteriosus]]
*[[Peripheral shunt]]
*[[Peutz-Jeghers syndrome]]
*[[Phosgene|Phosgene inhalation]]
*[[Pleural fibroma ]]
*[[POEMS syndrome ]]
*[[Polyamide|Polyamide-amine dyes inhalation]]
*[[Polyarteritis nodosa]]
*[[Primary biliary cirrhosis]]
*[[Primary pulmonary hypertension]]
*[[Pulmonary alveolar proteinosis]]
*[[Aneurysm|Pulmonary arterio-veinous aneurysm]]
*[[Pulmonary arteriovenous malformation]]
*[[Pulmonary artery sarcoma]]
*[[Pulmonary artery sclerosis]]
*[[Pulmonary fibrosis]]
*[[Granuloma|Pulmonary granuloma]]
*[[Pulmonary hypertension]]
*[[Lymphoma |Pulmonary lymphoma]]
*[[Pulmonary metastases]]
*[[Pulmonary surfactant-associated protein B|pulmonary surfactant protein b, deficiency]]
*[[Pulmonary hypertension|Pulmonary thromboembolic hypertension]]
*[[Pulmonary tuberculosis]]
*[[Pulmonic stenosis]]
*[[Right-to-left shunt|Right-to-left cardiac shunts]]
*[[Sarcoidosis]]
*[[Secondary pulmonary hypertension]]
*[[Senna]]
*[[Shell nail syndrome]]
*[[Silicosis]]
*[[Small bowel lymphoma]]
*[[Sprue]]
*[[Stomach cancer]]
*[[Subacute bacterial endocarditis]]
*[[Sulfur dioxide|Sulphur dioxide inhalation]]
*[[Pulmonary surfactant|Surfactant metabolism dysfunction]]
*[[Taussig-Bing syndrome ]]
*[[Tetralogy of fallot]]
*[[Thionyl chloride|Thionyl chloride inhalation]]
*[[Thyroid cancer]]
*[[Thyrotoxicosis]]
*[[Total anomalous venous connection]]
*[[Transposition of the great vessels]]
*[[Tricuspid atresia]]
*[[Truncus arteriosus]]
*[[Tuberculosis]]
*[[Ulcerative colitis]]
*[[Vascular anomaly|Vascular anomalies]]
*[[Ventricular septal defect]]
*[[Whipple disease]]


* [[Interstitial lung disease]]
}}
* [[Liver tumor]]s
* [[Lung abscess]]<ref name="pmid17273583">{{cite journal |author=Moreira Jda S, Camargo Jde J, Felicetti JC, Goldenfun PR, Moreira AL, Porto Nda S |title=Lung abscess: analysis of 252 consecutive cases diagnosed between 1968 and 2004 |journal=J Bras Pneumol |volume=32 |issue=2 |pages=136–43 |year=2006 |pmid=17273583 |doi= |url=}}</ref>
* [[Metastatic melanoma]]<ref name="pmid16314744">{{cite journal |author=Thompson MA, Warner NB, Hwu WJ |title=Hypertrophic osteoarthropathy associated with metastatic melanoma |journal=Melanoma Res. |volume=15 |issue=6 |pages=559–61 |year=2005 |month=December |pmid=16314744 |doi= |url=}}</ref>
* [[Mesothelioma]]<ref name="pmid9659538">{{cite journal |author=McGavin C, Hughes P |title=Finger clubbing in malignant mesothelioma and benign asbestos pleural disease |journal=Respir Med |volume=92 |issue=4 |pages=691–2 |year=1998 |month=April |pmid=9659538 |doi= |url=}}</ref>
* [[Myelofibrosis]]<ref name="pmid18038138">{{cite journal |author=Saghafi M, Azarian A, Nohesara N |title=Primary hypertrophic osteoarthropathy with myelofibrosis |journal=Rheumatol. Int. |volume=28 |issue=6 |pages=597–600 |year=2008 |month=April |pmid=18038138 |doi=10.1007/s00296-007-0477-4 |url=}}</ref>
* [[Nasopharyngeal carcinoma]]<ref name="pmid19402293">{{cite journal |author=Ali N, Abbasi AN, Karsan F, Hashmi R, Badar QA, Sheikh AJ |title=A case of finger clubbing associated with nasopharyngeal carcinoma in a young girl, and review of pathophysiology |journal=J Pak Med Assoc |volume=59 |issue=4 |pages=253–4 |year=2009 |month=April |pmid=19402293 |doi= |url=}}</ref>
* [[Pachydermoperiostosis]]
* [[POEMS syndrome]] ([[polyneuropathy]], [[organomegaly]], [[endocrinopathy]], [[monoclonal gammopathy]], and [[skin changes]]): a rare paraneoplastic syndrome secondary to a plasma cell dyscrasia in which clubbing may be seen. Other findings including peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma proliferative disorder, skin changes, sclerotic bone lesions, Castleman disease, thrombocytosis, papilledema, peripheral edema, pleural effusions, ascites, and white nails.
* [[Primary biliary cirrhosis]]<ref name="pmid2295472">{{cite journal |author=Stoller JK, Moodie D, Schiavone WA, ''et al.'' |title=Reduction of intrapulmonary shunt and resolution of digital clubbing associated with primary biliary cirrhosis after liver transplantation |journal=Hepatology |volume=11 |issue=1 |pages=54–8 |year=1990 |month=January |pmid=2295472 |doi= |url=}}</ref>
* [[Pulmonic stenosis]]
* [[Pulmonary artery sarcoma]]<ref name="pmid8769527">{{cite journal |author=Loredo JS, Fedullo PF, Piovella F, Moser KM |title=Digital clubbing associated with pulmonary artery sarcoma |journal=Chest |volume=109 |issue=6 |pages=1651–3 |year=1996 |month=June |pmid=8769527 |doi= |url=}}</ref>
* [[Pulmonary artery sclerosis]]
* [[Pulmonary fibrosis]]
* [[Pulmonary metastases]]
* [[Right-to-left cardiac shunt]]s
* [[Sarcoidosis]] of the lungs <ref name="pmid">{{cite journal |author=West SG, Gilbreath RE, Lawless OJ |title=Painful clubbing and sarcoidosis |journal=JAMA |volume=246 |issue=12 |pages=1338–9 |year=1981 |month=September |pmid= |doi= |url=}}</ref>
* [[Silicosis]]<ref name="pmid3340919">{{cite journal |author=Ehrlich RI, Gerston KF, Lalloo UG |title=Accelerated silicosis in a foundry shotblaster. A case report |journal=S. Afr. Med. J. |volume=73 |issue=2 |pages=128–30 |year=1988 |month=January |pmid=3340919 |doi= |url=}}</ref>
* [[Sprue]]
* [[Thyroid cancer]]
* [[Thyrotoxicosis]]
* [[Tuberculosis]]
* [[Ulcerative colitis]]
* [[Vascular anomalies]]


==References==
==References==

Latest revision as of 20:36, 10 January 2020

Clubbing Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Clubbing from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

Echocardiography or Ultrasound

Other Diagnostic Studies

Treatment

Medical Therapy

Case Studies

Case #1

Clubbing causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Clubbing causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Clubbing causes

CDC on Clubbing causes

Clubbing causes in the news

Blogs on Clubbing causes

Directions to Hospitals Treating Clubbing

Risk calculators and risk factors for Clubbing causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2]

Overview

Life threatening causes of clubbing include lung cancer, tetralogy of fallot, transposition of great vessels, and tricuspid atresia. Other common causes of clubbing are bronchiectasis, cystic fibrosis, cirrhosis, and empyema.

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular Aneurysm, arterial vascular prosthesis infections, arteriovenous fistula, arteriovenous malformations, atrial myxoma, atrial septal defect, cerebrovascular insult, chronic hypoxia, common ventricle, congenital cardiovascular malformations, congestive heart failure, cyanotic congenital heart disease, conotruncal heart malformations, double outlet right ventricle, Eisenmenger syndrome, endocarditis, erythromelalgia , patent ductus arteriosus, pulmonary thromboembolic hypertension, right-to-left shunting, subacute bacterial endocarditis, Taussig-Bing syndrome, tetralogy of fallot, total anomalous pulmonary venous connection, transposition of the great vessels, tricuspid atresia, truncus arteriosus, pulmonic stenosis, heart cancer, ventricular septal defect.
Chemical / poisoning Ammonia inhalation, chlorine inhalation, diacetyl inhalation, hydrogen bromide inhalation, hydrogen chloride inhalation, hydrogen fluoride inhalation, hydrogen sulfide inhalation, methyl isocyanate inhalation, nitrogen oxide inhalation, Ozone inhalation, phosgene inhalation, polyamide-amine dyes inhalation, sulfur dioxide inhalation, thionyl chloride inhalation
Dermatologic Hereditary haemorrhagic telangiectasia, hidrotic ectodermal dysplasia, Shell nail syndrome
Drug Side Effect Cannabis, dexfenfluramine, fenfluramine, Interferon gamma, Senna
Ear Nose Throat Hereditary hemorrhagic telangiectasia, nasopharyngeal carcinoma
Endocrine Graves disease, Thyroid cancer, Thyrotoxicosis, POEMS syndrome
Environmental Mesothelioma, silicosis
Gastroenterologic Achalasia,celiac sprue, chronic liver disease, chronic obstructive jaundice, cirrhosis of liver, Crohn disease, cystic fibrosis, gastrointestinal neoplasms, hepatoma, hepatopulmonary syndrome, Inflammatory bowel disease, leiomyoma of the esophagus, liver tumors, malabsorption, oesophageal cancer, Peutz-Jeghers syndrome, primary biliary cirrhosis, small bowel lymphoma, stomach cancer, ulcerative colitis, Whipple disease
Genetic Celiac disease, crohn's disease, Cystic fibrosis, dextrocardia-bronchiectasis-sinusitis, Ebstein's anomaly, Eisenmenger syndrome, Peutz-Jeghers Syndrome, Taussig-Bing syndrome , hereditary haemorrhagic telangiectasia, Ivemark syndrome, Jansen's metaphyseal chondrodysplasia , pachydermoperiostosis
Hematologic Hodgkin lymphoma, Myelofibrosis
Iatrogenic No underlying causes
Infectious Disease Aspergillosis, empyema, Infective endocarditis, lymphadenitis, pulmonary abscess, pulmonary tuberculosis, subacute bacterial endocarditis, tuberculosis,
Musculoskeletal / Ortho Jansen's metaphyseal chondrodysplasia
Neurologic Cerebrovascular insult, hereditary hemorrhagic telangiectasia
Nutritional / Metabolic Celiac sprue, cystic fibrosis
Obstetric/Gynecologic No underlying causes
Oncologic Atrial myxoma, bronchial carcinoma, Hodgkin's disease, lung cancer, mesothelioma, metastatic melanoma, myelofibrosis , nasopharyngeal carcinoma, pancoast tumor, pleural fibroma, pleural mesothelioma,POEMS syndrome, Stomach cancer

thyroid cancer, thymus cancer

Opthalmologic No underlying causes
Overdose / Toxicity Cannabis
Psychiatric No underlying causes
Pulmonary Asbestosis, asthma complicated by infection, berylliosis,bronchial carcinoma,bronchiectasis, bronchiolitis obliterans, bronchogenic carcinoma, chronic hypoxia,chronic obstructive pulmonary disease ,cryptogenic fibrosing alveolitis,cystic fibrosis, emphysema,empyema,extrathoracic disease, extrinsic allergic alveolitis, familial interstitial fibrosis, familial pulmonary arterial hypertension, fibrosing alveolitis, Hamman-Rich Syndrome , hepatopulmonary syndrome, hypersensitivity pneumonitis,hypertrophic pulmonary osteoarthropathy, idiopathic diffuse interstitial fibrosis, idiopathic pulmonary fibrosis, idiopathic pulmonary haemosiderosis, idiopathic pulmonary hypertension , interstitial fibrosis, interstitial lung disease,interstitial pneumonitis, lipoid pneumonia,lung cancer, Marie-bamberg syndrome,pancoast tumor, pleural fibroma, pleural mesothelioma,polyarteritis nodosa,primary pulmonary hypertension, pulmonary abscess, pulmonary alveolar proteinosis, pulmonary arteriovenous malformation, pulmonary artery sarcoma,pulmonary artery sclerosis, pulmonary fibrosis, pulmonary granuloma, pulmonary hypertension, pulmonary lymphoma, pulmonary metastases, pulmonary surfactant protein b, deficiency, pulmonary thromboembolic hypertension, pulmonary tuberculosis, pulmonic stenosis, sarcoidosis, Secondary pulmonary hypertension, silicosis, surfactant metabolism dysfunction.
Renal / Electrolyte Polyarteritis nodosa
Rheum / Immune / Allergy Alpha heavy chain disease, celiac sprue, crohn's disease, Fischer syndrome, Graves disease, Kindler-weary bullous acrokeratotic poikiloderma, lymphoid interstitial pneumonia, polyarteritis nodosa, sarcoidosis.
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous Bindewald-ulmer-muller syndrome

Causes in Alphabetical Order

References

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Clubbing_causes&oldid=1594737"