Clofoctol: Difference between revisions

Jump to navigation Jump to search
m (Bot: Automated text replacement (-{{SIB}} + & -{{EH}} + & -{{EJ}} + & -{{Editor Help}} + & -{{Editor Join}} +))
No edit summary
 
Line 1: Line 1:
{{drugbox
{{Drugbox
| IUPAC_name       = 2-[(2,4-dichlorophenyl)methyl]-<br>4-(2,4,4-trimethylpentan-2-yl)phenol
| Watchedfields = changed
| image             = Clofoctol.svg
| verifiedrevid = 443553734
| CAS_number        = 37693-01-9
| IUPAC_name = 2-[(2,4-dichlorophenyl)methyl]-<br>4-(2,4,4-trimethylpentan-2-yl)phenol
| ATC_prefix        = J01
| image = Clofoctol Wiki Str.png
| ATC_suffix        = XX03
 
| PubChem          = 2799
| alt = Structural formula of clofoctol
| DrugBank          =
| width = 250
| C=21|H=26|Cl=2|O=1
 
| molecular_weight  = 365.336 g/mol
<!--Clinical data-->
| bioavailability  = 98%<ref name=Gramplus/>
| tradename =
| protein_bound    =  
| Drugs.com = {{drugs.com|international|clofoctol}}
| metabolism        = [[Hepatic]] [[glucuronidation]]<ref name=Gramplus/>
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| elimination_half-life =
| pregnancy_US = <!-- A / B            / C / D / X -->
| excretion        = Biliary<ref name=Gramplus/>
| pregnancy_category =   
| pregnancy_AU     = <!-- A / B1 / B2 / B3 / C / D / X -->
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| pregnancy_US     = <!-- A / B            / C / D / X -->
| legal_CA = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| pregnancy_category=   
| legal_UK = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_AU         = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_US = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_CA         = <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_status =
| legal_UK         = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| routes_of_administration = Rectal ([[suppository]])<ref name=Gramplus/>
| legal_US         = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
 
| legal_status     =  
<!--Pharmacokinetic data-->
| routes_of_administration = Rectal ([[suppository]])<ref name=Gramplus/><ref name=BIAM/>
| bioavailability = 98%<ref name=Gramplus/>
| protein_bound = 
| metabolism = [[Hepatic]] [[glucuronidation]]<ref name=Gramplus/>
| elimination_half-life = 
| excretion = Biliary<ref name=Gramplus/>
 
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 37693-01-9
| ATC_prefix = J01
| ATC_suffix = XX03
| PubChem = 2799
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = 
| ChEMBL = 1476605
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 2697
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 704083NI0R
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07244
 
<!--Chemical data-->
| C=21 | H=26 | Cl=2 | O=1
| molecular_weight = 365.336 g/mol
| smiles = Clc1cc(Cl)ccc1Cc2cc(ccc2O)C(C)(C)CC(C)(C)C
| InChI = 1/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
| InChIKey = HQVZOORKDNCGCK-UHFFFAOYAB
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C21H26Cl2O/c1-20(2,3)13-21(4,5)16-7-9-19(24)15(11-16)10-14-6-8-17(22)12-18(14)23/h6-9,11-12,24H,10,13H2,1-5H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = HQVZOORKDNCGCK-UHFFFAOYSA-N
}}
}}
__NOTOC__
{{SI}}
{{SI}}
{{CMG}}
== Overview ==


'''Clofoctol''' is a [[bacteriostatic]] [[antibiotic]]. It is used in the treatment of [[respiratory tract]] and ear, nose and throat infections caused by [[Gram-positive]] [[bacteria]].<ref name=Gramplus>{{cite web | url = http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm | title = Gramplus | date = July 25, 2007 | accessdate = 2007-08-10 | publisher = Studio Medico Torrino | language = Italian}}</ref>
It is marketed in [[France]] under the trade name '''Octoplus''' and in [[Italy]] as '''Gramplus'''.


'''Clofoctol''' is a [[bacteriostatic]] [[antibiotic]]. It is used in the treatment of [[respiratory tract]] and ear, nose and throat infections caused by [[Gram-positive]] [[bacteria]].<ref name=Gramplus>{{cite web | url = http://www.torrinomedica.it/studio/schedefarmaci/GRAMPLUS.htm | title = Gramplus | date = [[July 25]] [[2007]] | accessdate = 2007-08-10 | publisher = Studio Medico Torrino | language = Italian}}</ref><ref name=BIAM>{{cite web | url = http://www.biam2.org/www/Sub3508.html | title = Clofoctol | date = [[July 16]] [[1999]] | accessdate = 2007-08-10 | publisher = BIAM | language = French}}</ref>
It is only functional against [[Gram-positive bacteria]].<ref name="pmid6782374">{{cite journal |author=Combe J, Simonnet F, Yablonsky F, Simonnet G |title=[Clofoctol binding by the bacteria (author's transl)] |language=French |journal=J Pharmacol |volume=11 |issue=4 |pages=411–25 |year=1980 |pmid=6782374 |doi=}}</ref>


It is marketed in [[France]] under the trade name '''Octoplus''' and in [[Italy]] as '''Gramplus'''.
It penetrates into human lung tissue.<ref name="pmid3391105">{{cite journal |author=Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M |title=A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay |journal=Drugs Exp Clin Res |volume=14 |issue=1 |pages=39–43 |year=1988 |pmid=3391105 |doi= |url=}}</ref>


==References==
==References==
{{Reflist}}
{{Reflist|2}}




{{Antibiotic-stub}}
{{Other antibacterials}}
{{Other antibacterials}}


[[Category:drug]]
[[Category:Antibiotics]]
[[Category:Antibiotics]]
 
[[Category:Phenols]]
 
[[Category:Organochlorides]]
{{WikiDoc Help Menu}}
{{WS}}

Latest revision as of 15:36, 14 April 2015

Clofoctol
Structural formula of clofoctol
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
Rectal (suppository)[1]
ATC code
Pharmacokinetic data
Bioavailability98%[1]
MetabolismHepatic glucuronidation[1]
ExcretionBiliary[1]
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC21H26Cl2O
Molar mass365.336 g/mol
3D model (JSmol)
  (verify)

WikiDoc Resources for Clofoctol

Articles

Most recent articles on Clofoctol

Most cited articles on Clofoctol

Review articles on Clofoctol

Articles on Clofoctol in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Clofoctol

Images of Clofoctol

Photos of Clofoctol

Podcasts & MP3s on Clofoctol

Videos on Clofoctol

Evidence Based Medicine

Cochrane Collaboration on Clofoctol

Bandolier on Clofoctol

TRIP on Clofoctol

Clinical Trials

Ongoing Trials on Clofoctol at Clinical Trials.gov

Trial results on Clofoctol

Clinical Trials on Clofoctol at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Clofoctol

NICE Guidance on Clofoctol

NHS PRODIGY Guidance

FDA on Clofoctol

CDC on Clofoctol

Books

Books on Clofoctol

News

Clofoctol in the news

Be alerted to news on Clofoctol

News trends on Clofoctol

Commentary

Blogs on Clofoctol

Definitions

Definitions of Clofoctol

Patient Resources / Community

Patient resources on Clofoctol

Discussion groups on Clofoctol

Patient Handouts on Clofoctol

Directions to Hospitals Treating Clofoctol

Risk calculators and risk factors for Clofoctol

Healthcare Provider Resources

Symptoms of Clofoctol

Causes & Risk Factors for Clofoctol

Diagnostic studies for Clofoctol

Treatment of Clofoctol

Continuing Medical Education (CME)

CME Programs on Clofoctol

International

Clofoctol en Espanol

Clofoctol en Francais

Business

Clofoctol in the Marketplace

Patents on Clofoctol

Experimental / Informatics

List of terms related to Clofoctol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Clofoctol is a bacteriostatic antibiotic. It is used in the treatment of respiratory tract and ear, nose and throat infections caused by Gram-positive bacteria.[1] It is marketed in France under the trade name Octoplus and in Italy as Gramplus.

It is only functional against Gram-positive bacteria.[2]

It penetrates into human lung tissue.[3]

References

  1. 1.0 1.1 1.2 1.3 1.4 "Gramplus" (in Italian). Studio Medico Torrino. July 25, 2007. Retrieved 2007-08-10.
  2. Combe J, Simonnet F, Yablonsky F, Simonnet G (1980). "[Clofoctol binding by the bacteria (author's transl)]". J Pharmacol (in French). 11 (4): 411–25. PMID 6782374.
  3. Danesi R, Gasperini M, Senesi S, Freer G, Angeletti CA, Del Tacca M (1988). "A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay". Drugs Exp Clin Res. 14 (1): 39–43. PMID 3391105.


Template:Antibiotic-stub Template:Other antibacterials