Churg-Strauss syndrome history and symptoms: Difference between revisions
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==Symptoms== | ==Symptoms== | ||
The initial signs that are seen in patients presenting with Eosinophilic granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Eosinophilic granulomatosis with polyangiitis: | The initial signs that are seen in patients presenting with Eosinophilic granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Eosinophilic granulomatosis with polyangiitis:<ref name="pmid25500434">{{cite journal| author=Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Ruoppolo G et al.| title=Churg-Strauss syndrome. | journal=Autoimmun Rev | year= 2015 | volume= 14 | issue= 4 | pages= 341-8 | pmid=25500434 | doi=10.1016/j.autrev.2014.12.004 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25500434 }}</ref> | ||
===Prodromal phase=== | ===Prodromal phase=== | ||
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* Otitis media | * Otitis media | ||
* Sensorineural hearing loss | * Sensorineural hearing loss | ||
* Asthenia | |||
===Eosinophilic phase=== | ===Eosinophilic phase=== | ||
Revision as of 17:17, 14 November 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]
Overview
History
Obtaining a complete history is an important aspect in making a clinical diagnosis of Eosinophilic granulomatosis with polynagiitis. As it can help differentiate between the ANCA associated vasculitis and other possible causes that may mimic the disease. They include:
- Granulomatosis with polyangiitis
- Microscopic polyangiitis
- Idiopathic hyper-eosinophilic syndrome
- Drug induced
Symptoms
The initial signs that are seen in patients presenting with Eosinophilic granulomatosis with polyangiitis are non-specific in nature. The following are signs and symptoms of Eosinophilic granulomatosis with polyangiitis:[1]
Prodromal phase
- Arthralgia
- Myalgia
- Pyrexia
- Weight loss
- Asthma
- Nasal polyps
- Allergic rhinitis,
- Sinusitis
- Otitis media
- Sensorineural hearing loss
- Asthenia
Eosinophilic phase
- Peripheral eosinophilia
- Pulmonary infiltrates
- Ground glass opacities
- Thickening of the bronchial wall
- Endomyocardial infiltrates
- Arrhythmia
- Pericarditis
- Abdominal pain
Vascular phase
- Pyrexia
- Weight loss
- Fatigue
- Multiplex mononeuritis
- Cerebral infarctions
- Rapid progressive glomerulonephritis
- Pauci-immune focal and segmental necrotizing glomerulonephritis
- Palpable purpura and nodules
- Maculopapular erythematous
- Livedo reticularis
- Petechiae
- Ecchymoses
References
- ↑ Greco A, Rizzo MI, De Virgilio A, Gallo A, Fusconi M, Ruoppolo G; et al. (2015). "Churg-Strauss syndrome". Autoimmun Rev. 14 (4): 341–8. doi:10.1016/j.autrev.2014.12.004. PMID 25500434.