Churg-Strauss syndrome (patient information): Difference between revisions

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==Overview==
==Overview==
[[Eosinophilic granulomatosis with polyangiitis]] previously called [[Eosinophilic granulomatosis with polyangiitis|Churg-Strauss syndrome]] involves primarily small and medium sized blood vessels resulting in vessel inflammation. The exact cause of the disease is not known. However, various environmental factors, [[Allergen|allergens]], [[genetics]], and [[:Category:Drugs|drugs]] may play a role in triggering [[disease]] process by activating different types of white blood cells. The disease is characterized by the presence of [[asthma]], peripheral [[eosinophilia]], [[rhinosinusitis]], [[Paresthesia|tingling and numbness of hands and feet]] ([[peripheral neuropathy]]) and multiple [[Organ (anatomy)|organ]] involvements including [[skin]], [[Gastrointestinal tract|GI tract]], and [[kidney]].
[[Eosinophilic granulomatosis with polyangiitis]] previously called [[Eosinophilic granulomatosis with polyangiitis|Churg-Strauss syndrome]] involves primarily small and medium sized blood vessels resulting in vessel inflammation. The exact cause of the disease is not known. However, various environmental factors, [[Allergen|allergens]], [[genetics]], and [[:Category:Drugs|drugs]] may play a role in triggering [[disease]] process by activating different types of white blood cells. The disease is characterized by the presence of [[asthma]], [[hypereosinophilia]], [[rhinosinusitis]], [[Paresthesia|tingling and numbness of hands and feet]] ([[peripheral neuropathy]]) and multiple [[Organ (anatomy)|organ]] involvements including [[skin]], [[Gastrointestinal tract|GI tract]], and [[kidney]].


==What are the symptoms of Churg-Strauss syndrome==
==What are the symptoms of Churg-Strauss syndrome==
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==Diagnosis==
==Diagnosis==
Physical examination of lungs, heart, nervous system, skin and upper airway tract, along with the following tests can help in find
Physical examination of lungs, heart, nervous system, skin and upper airway tract, along with the following tests can help in find
* CBC with differential count
* [[Complete blood count|CBC with differential count]]
* Chest X-ray
* [[Chest X-ray]]
* CT scan of chest
* [[Computed tomography|CT scan]] of chest
* Urinalysis
* Urine analysis
* Bronchoscopy.
* Serologic test for [[Anti-neutrophil cytoplasmic antibody|anti-neutrophil cytoplasmic antibodies]] ([[Anti-neutrophil cytoplasmic antibody|ANCA]])
* Biopsy of lung, skin, kidney and nerve
* [[Biopsy]] of lung, skin, kidney and nerve


==When to seek urgent medical care?==
==When to seek urgent medical care?==

Revision as of 20:04, 12 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Eosinophilic granulomatosis with polyangiitis previously called Churg-Strauss syndrome involves primarily small and medium sized blood vessels resulting in vessel inflammation. The exact cause of the disease is not known. However, various environmental factors, allergensgenetics, and drugs may play a role in triggering disease process by activating different types of white blood cells. The disease is characterized by the presence of asthma, hypereosinophiliarhinosinusitistingling and numbness of hands and feet (peripheral neuropathy) and multiple organ involvements including skinGI tract, and kidney.

What are the symptoms of Churg-Strauss syndrome

Symptoms of eosinophilic granulomatosis with polyangiitis typically develops through three phases, include prodromal phase, eosinophilic phase, and vasculitis phase. Although these phases cannot be clinically distinguishable.

What causes Churg-Strauss syndrome?

There are no established causes for eosinophilic granulomatosis with polyangiitis. However, various allergensinfectionsvaccinations and drugs may act as a triggering agents, and are responsible for developing disease. Genetics may also play a role.

Who is at highest risk?

Any one can develop eosinophilic granulomatosis with polyangiitis. Studies shown, it occurs mostly between 40-60 years with people having chronic history of asthma and allergic manifestations.

Diagnosis

Physical examination of lungs, heart, nervous system, skin and upper airway tract, along with the following tests can help in find

When to seek urgent medical care?

You should see the doctor if you experience any of the following:

The above symptoms may also present in association with other diseases, but they have to be evaluated properly by medical professional.

Treatment Options

Where to find medical care for Churg-Strauss syndrome

Prevention

Currently, there are no established preventive measures for eosinophilic granulomatosis with polyangiitis.

What to expect (Outlook/Prognosis)?

  • With treatment, the outlook for most patients is good.
  • Studies have shown that most people who receive and cyclophosphamide are doing much better. However, the disease relapses are common.

Possible Complications

Without treatment, eosinophilic granulomatosis with polyangiitis can result in the following complications. Complications depend on organ system involvement.

Sources

References

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