Chronic neutrophilic leukemia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]
Overview
The etiology of Chronic neutrophilic leukemia (CNL) is unknown. An association between CNL and multiple myeloma has been suggested.
Etiology
The etiology of CNL is currently unknown. An association between CNL and multiple myeloma has been suggested based on the observation of myeloma in 20% of CNL cases.[1] However, a clonal genetic abnormality has not been detected in these myeloma-associated cases of CNL, raising the possibility that the neutrophilia is a reaction due to the neoplastic myeloma cells. The postulated cell of origin is a limited-potential, marrow-derived stem cell.[2]
References
- ↑ [1] Standen GR, Steers FJ, Jones L. "Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta." J Clin Pathol. 1993 Apr;46(4):297-8. PMID: 8098719
- ↑ [2] Yanagisawa K, Ohminami H, Sato M, Takada K, Hasegawa H, Yasukawa M, Fujita S. "Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia." Am J Hematol. 1998 Mar;57(3):221-4. PMID: 9495373