Chronic neutrophilic leukemia causes: Difference between revisions
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==Overview== | ==Overview== | ||
==Etiology== | |||
The etiology of CNL is currently unknown. An association between CNL and [[multiple myeloma]] has been suggested based on the observation of myeloma in 20% of CNL cases.<ref name="sta1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8098719&query_hl=7&itool=pubmed_ExternalLink] | |||
Standen GR, Steers FJ, Jones L. "Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta." '''J Clin Pathol'''. 1993 Apr;46(4):297-8. '''PMID''': 8098719</ref> However, a clonal genetic abnormality has not been detected in these myeloma-associated cases of CNL, raising the possibility that the [[neutrophilia]] is a reaction due to the neoplastic [[myeloma]] cells.<ref name="who1"/> The postulated cell of origin is a limited-potential, marrow-derived stem cell.<ref name="yan1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9495373&query_hl=10&itool=pubmed_ExternalLink] | |||
Yanagisawa K, Ohminami H, Sato M, Takada K, Hasegawa H, Yasukawa M, Fujita S. "Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia." '''Am J Hematol'''. 1998 Mar;57(3):221-4. '''PMID''': 9495373</ref> | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [3]
Overview
Etiology
The etiology of CNL is currently unknown. An association between CNL and multiple myeloma has been suggested based on the observation of myeloma in 20% of CNL cases.[1] However, a clonal genetic abnormality has not been detected in these myeloma-associated cases of CNL, raising the possibility that the neutrophilia is a reaction due to the neoplastic myeloma cells.[2] The postulated cell of origin is a limited-potential, marrow-derived stem cell.[3]
References
- ↑ [1] Standen GR, Steers FJ, Jones L. "Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta." J Clin Pathol. 1993 Apr;46(4):297-8. PMID: 8098719
- ↑
- ↑ [2] Yanagisawa K, Ohminami H, Sato M, Takada K, Hasegawa H, Yasukawa M, Fujita S. "Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia." Am J Hematol. 1998 Mar;57(3):221-4. PMID: 9495373