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{{Chronic neutrophilic leukemia}}
{{Chronic neutrophilic leukemia}}
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==Overview==
==Overview==


The [[etiology]] of Chronic neutrophilic leukemia (CNL) is unknown.
==Etiology==
==Etiology==
The etiology of CNL is currently unknown. An association between CNL and [[multiple myeloma]] has been suggested based on the observation of myeloma in 20% of CNL cases.<ref name="sta1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=8098719&query_hl=7&itool=pubmed_ExternalLink]
The [[etiology]] of CNL is currently unknown.  
Standen GR, Steers FJ, Jones L. "Clonality of chronic neutrophilic leukaemia associated with myeloma: analysis using the X-linked probe M27 beta." '''J Clin Pathol'''. 1993 Apr;46(4):297-8. '''PMID''': 8098719</ref> However, a clonal genetic abnormality has not been detected in these myeloma-associated cases of CNL, raising the possibility that the [[neutrophilia]] is a reaction due to the neoplastic [[myeloma]] cells. The postulated cell of origin is a limited-potential, marrow-derived stem cell.<ref name="yan1">[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=9495373&query_hl=10&itool=pubmed_ExternalLink]
Yanagisawa K, Ohminami H, Sato M, Takada K, Hasegawa H, Yasukawa M, Fujita S. "Neoplastic involvement of granulocytic lineage, not granulocytic-monocytic, monocytic, or erythrocytic lineage, in a patient with chronic neutrophilic leukemia." '''Am J Hematol'''. 1998 Mar;57(3):221-4. '''PMID''': 9495373</ref>


==References==
==References==
{{reflist|2}}
{{reflist|2}}
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Latest revision as of 20:57, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]

Overview

The etiology of Chronic neutrophilic leukemia (CNL) is unknown.

Etiology

The etiology of CNL is currently unknown.

References


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