Chronic myelogenous leukemia laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Laboratory findings consistent with the diagnosis of chronic myelogenous leukemia in CBC include: thrombocytosis and/or marked leukocytosis (median of 100,000/µL) with a left shift, blasts usually number <2%, absolute basophilia is nearly universal, absolute eosinophilia, monocytosis and normal or elevated platelet count; thrombocytopenia suggests an alternative diagnosis or the presence of advanced stage. elevated uric acid levels and elevated histamine levels due to basophilia are other laboratory findings.[1]
Laboratory Findings
Laboratory findings consistent with the diagnosis of chronic myelogenous leukemia include:
- thrombocytosis and/or marked leukocytosis (median of 100,000/µL) with a left shift
- blasts usually number <2%
- absolute basophilia is nearly universal
- absolute eosinophilia
- monocytosis
- normal or elevated platelet count
- thrombocytopenia
- elevated uric acid levels
- elevated histamine levels due to basophilia
Gallery
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![Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]](/images/b/ba/CML.jpg)
Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]
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![A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]](/images/4/4c/Leukemia-flurescent.jpg)
A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]
![Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]](/index.php/File:CML.jpg)
![A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]](/index.php/File:Leukemia-flurescent.jpg)
References
- ↑ Thompson PA, Kantarjian HM, Cortes JE (October 2015). "Diagnosis and Treatment of Chronic Myeloid Leukemia in 2015". Mayo Clin. Proc. 90 (10): 1440–54. doi:10.1016/j.mayocp.2015.08.010. PMC 5656269. PMID 26434969.
- ↑ 2.0 2.1 Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details_linked.asp?pid=6