Chronic myelogenous leukemia laboratory tests: Difference between revisions
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*[[Fluorescent in situ hybridization]] (FISH) | *[[Fluorescent in situ hybridization]] (FISH) | ||
:*Similar to cytogenetics, but more specific | :*Similar to cytogenetics, but more specific | ||
Revision as of 21:52, 10 November 2015
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Chronic myelogenous leukemia Microchapters |
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Differentiating Chronic myelogenous leukemia from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Chronic myelogenous leukemia laboratory tests On the Web |
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American Roentgen Ray Society Images of Chronic myelogenous leukemia laboratory tests |
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Directions to Hospitals Treating Chronic myelogenous leukemia |
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Risk calculators and risk factors for Chronic myelogenous leukemia laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
Laboratory findings consistent with the diagnosis of chronic myelogenous leukemia include leukocytosis, thrombocytopenia, and anemia.
Laboratory Findings
Laboratory findings associated with chronic myelogenous leukemia include:[1]
- Increased granulocytes of all types, especially basophils and eosinophils
- Thrombocytopenia
- Anemia
- Blood chemistry
- The following may be elevated:
- Blood urea nitrogen (BUN)
- Creatinine
- Phosphate
- Lactate dehydrogenase (LDH)
- Alanine aminotransferase (ALT)
- Aspartate transaminase (AST)
- Uric acid
- Bleeding and clotting factor
- The following blood levels may be elevated:
- Prothrombin time (PT) or international normalized ratio (INR)
- Partial thromboplastin time (PTT)
- Cytochemistry helps determine the type of cells that are present
- Flow cytometry helps determine the type of cells that are present
- Chromosome changes that may occur in some people with leukemia include:
- Translocations
- Inversions
- Loss or gain of a chromosome number
- Similar to cytogenetics, but more specific
- Polymerase chain reaction
- Helpful to detect specific abnormalities in blood or bone marrow cells. Abnormalities can be found even if very few leukemia cells are present in a tissue sample.
Gallery
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![Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]](/images/b/ba/CML.jpg)
Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]
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![A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]](/images/4/4c/Leukemia-flurescent.jpg)
A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]
![Blast crisis of chronic myelogenous leukemia (CML). Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of chronic myelogenous leukemia.[2]](/index.php/File:CML.jpg)
![A photomicrograph of leukemia cells using Direct Fluorescent Antibody staining technique (DFA).[2]](/index.php/File:Leukemia-flurescent.jpg)
References
- ↑ Canadian Cancer Society.2015.http://www.cancer.ca/en/cancer-information/cancer-type/leukemia-chronic-myelogenous-cml/diagnosis/?region=ab
- ↑ 2.0 2.1 Center for Disease Control and Prevention. Public Health Image Library 2015.http://phil.cdc.gov/phil/details_linked.asp?pid=6