Chronic lymphocytic leukemia epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]; Rim Halaby, M.D. [3]; Haytham Allaham, M.D. [4]
Overview
In 2011, the age-adjusted incidence of chronic lymphocytic leukemia (CLL) was 4.82 per 100,000 persons in the United States.[1] CLL is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age.
Epidemiology and Demographics
Prevalence
The prevalence of CLL ranges from a low of 10 per 100,000 patients, to a high of 50 per 100,000 patients with an average prevalence of 30 per 100,000 patients.
Incidence
- The incidence of CLL in developed countries is 4 per 100,000. It increases to more than 30 per 100,000 at age 80 yrs.
Age
- CLL is a disease of the elderly and is rarely encountered in individuals under the age of 40. Most (>75%) people newly diagnosed with CLL are over age 50. Thereafter the disease incidence increases with age. Of note, subclinical "disease" can be identified in up to 7-8% of individuals over the age of 70. That is, small clones of B cells with the characteristic CLL phenotype can be identified in many healthy elderly persons. The clinical significance of these cells is unknown.
- While the overall age-adjusted incidence of CLL in the United States between 2007 and 2011 is 4.4 per 100,000, the age-adjusted incidence of CLL by age category is:[1]
- Under 65 years: 1.4 per 100,000
- 65 and over: 25.2 per 100,000
Gender
- Chronic lymphocytic leukemia is more common in males, where two thirds of the patients are males.
- In the United States, the age-adjusted incidence of chronic lymphocytic leukemia by gender on 2011 is:[1]
- 6.44 per 100,000 among males
- 3.51 per 100,000 among females
Race
CLL is common in the white race compared to the black race.
Gallery
==References==
- ↑ 1.0 1.1 1.2 1.3 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2011/, based on November 2013 SEER data submission, posted to the SEER web site, April 2014.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 SEER Stat Fact Sheets: Chronic Lymphocytic Leukemia. National Cancer Institute (2015) http://seer.cancer.gov/statfacts/html/clyl.html Accessed on October, 12 2015