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{{Cholangitis}}
{{Cholangitis}}


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==Overview==
==Overview==


Parasites are commonly associated with cholangitis outside of the United States.  Parasites associated with cholangitis include the Ascaris, Opisthorchis, Clonorchis, Fasciola and Echinococcus.  Ascaris is thought to be the etiologic agent of recurrent pyogenic cholangitis (Oriental cholangiohepatitis) found in Hong Kong, Southeast Asia, Columbia, Italy and South Africa.  As they migrate to the biliary tree, they bring gut flora with them predisposing to bacterial infection. Dying worms lead to [[inflammation]], [[granulomatous]] scarring and [[fibrosis]] which may lead to [[biliary cirrhosis]]. Opisthorchis and Clonorchis are transmitted by raw fish in Asia, Europe and Siberia and “frequently” lead to the development of [[cholangiocarcinoma]].  Fasciola is transmitted by colonized watercress and does not predispose to cholangiocarcinoma.
==Epidemiology and Demographics==
===Prevalence===
*Within a span of ten years, 15–26% of people will suffer one or more episodes of [[biliary colic]], [[abdominal]] pain due to the passage of [[gallstones]] through the [[bile duct]] into the [[digestive tract]].<ref name="efg123"> Cholangitis. Wikipedia (2016). https://en.wikipedia.org/wiki/Ascending_cholangitis#Epidemiology Accessed on April 8, 2016</ref>
*2–3% of people will develop complications of obstruction in the form of acute cholangitis.
*The prevalence of gallstone diseases increase with age and body mass index, a mark of obesity.
**The risk is also increased in those who lose weight rapidly (after weight loss surgery, for example) due to alterations in the composition of the bile that makes it prone to form stones.
 
===Age===
*The condition mostly occurs in adults, with a reported median age at onset of 50-60 years.<ref name="efg123"> Cholangitis. Wikipedia (2016). https://en.wikipedia.org/wiki/Ascending_cholangitis#Epidemiology Accessed on April 8, 2016</ref>
 
===Gender===
*Gallstones are slightly more common in women than in men, and pregnancy increases the risk further.<ref name="efg123"> Cholangitis. Wikipedia (2016). https://en.wikipedia.org/wiki/Ascending_cholangitis#Epidemiology Accessed on April 8, 2016</ref>
 
===Race===
The prevalence of cholangitis does not vary by race.
 
===Developed Countries===
*In Western countries, about 15% of all people have gallstones in their [[gallbladder]], but the majority are unaware of this and have no symptoms.<ref name="efg123"> Cholangitis. Wikipedia (2016). https://en.wikipedia.org/wiki/Ascending_cholangitis#Epidemiology Accessed on April 8, 2016</ref>
   
===Underdeveloped Countries===
*Parasites, specifically including the species Ascaris, Opisthorchis, Clonorchis, Fasciola and Echinococcus, are commonly associated with cholangitis outside of the United States.<ref name="urlRadioGraphics: Biliary Infections: Spectrum of Imaging Findings and Management">{{cite web |url=http://pubs.rsna.org/doi/abs/10.1148/rg.297095051 |title=RadioGraphics: Biliary Infections: Spectrum of Imaging Findings and Management |format= |work= |accessdate=}}</ref>  
**Ascaris is thought to be the etiologic agent of recurrent pyogenic cholangitis (Oriental cholangiohepatitis) found in Hong Kong, Southeast Asia, Columbia, Italy and South Africa.  


==References==
==References==

Revision as of 21:30, 8 April 2016

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Epidemiology and Demographics

Prevalence

  • Within a span of ten years, 15–26% of people will suffer one or more episodes of biliary colic, abdominal pain due to the passage of gallstones through the bile duct into the digestive tract.[1]
  • 2–3% of people will develop complications of obstruction in the form of acute cholangitis.
  • The prevalence of gallstone diseases increase with age and body mass index, a mark of obesity.
    • The risk is also increased in those who lose weight rapidly (after weight loss surgery, for example) due to alterations in the composition of the bile that makes it prone to form stones.

Age

  • The condition mostly occurs in adults, with a reported median age at onset of 50-60 years.[1]

Gender

  • Gallstones are slightly more common in women than in men, and pregnancy increases the risk further.[1]

Race

The prevalence of cholangitis does not vary by race.

Developed Countries

  • In Western countries, about 15% of all people have gallstones in their gallbladder, but the majority are unaware of this and have no symptoms.[1]

Underdeveloped Countries

  • Parasites, specifically including the species Ascaris, Opisthorchis, Clonorchis, Fasciola and Echinococcus, are commonly associated with cholangitis outside of the United States.[2]
    • Ascaris is thought to be the etiologic agent of recurrent pyogenic cholangitis (Oriental cholangiohepatitis) found in Hong Kong, Southeast Asia, Columbia, Italy and South Africa.

References

  1. 1.0 1.1 1.2 1.3 Cholangitis. Wikipedia (2016). https://en.wikipedia.org/wiki/Ascending_cholangitis#Epidemiology Accessed on April 8, 2016
  2. "RadioGraphics: Biliary Infections: Spectrum of Imaging Findings and Management".


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