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| {{drugbox
| | __NOTOC__</font> |
| | IUPAC_name = 8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-<br>ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-<br>azabicyclo[4.2.0]oct-4-ene-5-carboxylic acid
| | {{Cefdinir}}</font> |
| | image = Cefdinir.png
| | {{CMG}}</font> |
| | CAS_number = 91832-40-5
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| | ATC_prefix = J01
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| | ATC_suffix = DD15
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| | ATC_supplemental =
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| | PubChem = 6399253
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| | DrugBank = APRD00644
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| | C = 14 | H = 13 | N = 5 | O = 5 | S = 2
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| | molecular_weight = 395.416 g/mol
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| | bioavailability = 16% to 21% (dose-dependent)
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| | protein_bound = 60% to 70%
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| | metabolism = Negligible
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| | elimination_half-life = 1.7 ± 0.6 hours
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| | excretion = [[Kidney|Renal]]
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| | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
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| | pregnancy_US = B
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| | pregnancy_category =
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| | legal_AU = <!-- Unscheduled / S2 / S4 / S8 -->
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| | legal_UK = <!-- GSL / P / POM / CD -->
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| | legal_US = Rx-only
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| | legal_status =
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| | routes_of_administration = Oral
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| }}
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| __NOTOC__
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| {{SI}} | |
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| '''Cefdinir''' (marketed by [[Abbott Laboratories]] under the [[brand name]] '''Omnicef''') is a semi-synthetic, [[broad-spectrum antibiotic]] in the third generation of the [[cephalosporin]] class, proven effective for common [[bacteria]]l [[infection]]s of the ear, sinus, throat, and skin. It was approved by the U.S. [[Food and Drug Administration]] (FDA) in December of 1997.
| | ==Overview==</font> |
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| ==Mechanism of action== | | ==Category==</font> |
| {{main|Cephalosporin}}
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| ==Indications==
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| Therapeutic uses of cefdinir include [[otitis media]], [[soft tissue]] infections, and [[respiratory tract]] infections, including sinusitis, strep throat, [[community-acquired pneumonia]] and acute exacerbations of [[bronchitis]].
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| ===Susceptible organisms===
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| Cefdinir is a [[bacteriocide|bacteriocidal]] antibiotic. It can be used to treat infections caused by several [[Gram-negative]] and [[Gram-positive]] bacteria, including:
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| ====Gram-negative====
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| *''[[Haemophilus influenzae]]''
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| *''[[Moraxella catarrhalis]]''
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| *''[[Escherichia coli]]''
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| *''[[Klebsiella]]'' spp.
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| *''[[Proteus mirabilis]]''
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| ====Gram-positive====
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| *''[[Staphylococcus aureus]]''
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| *''[[Streptococcus pneumoniae]]
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| *''[[Streptococcus pyogenes]]''
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| Like most third-generation cephalosporins (except [[Ceftazidime]]), cefdinir is not an effective treatment against infections caused by ''[[Pseudomonas aeruginosa]]''.
| | ==US Brand Names==</font> |
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| ==Side effects== | | ==FDA Package Insert==</font> |
| According to the Omnicef website, side effects include "(...) diarrhea, vaginal infections or inflammation, nausea, headache, and abdominal pain."<ref>{{cite web | title = Omnicef® capsules Patient Information | publisher = [[Abbott Laboratories]] | url = http://www.rxabbott.com/pdf/omnicef_capsules_patient_friendly.pdf | month = February | year = 2004 | accessdate = 2006-11-24}}</ref>
| | '''[[Cefdinir description|Description]]'''</font> |
| | '''| [[Cefdinir clinical pharmacology|Clinical Pharmacology]]'''</font> |
| | '''| [[Cefdinir microbiology|Microbiology]]'''</font> |
| | '''| [[Cefdinir indications and usage|Indications and Usage]]'''</font> |
| | '''| [[Cefdinir contraindications|Contraindications]]'''</font> |
| | '''| [[Cefdinir warnings|Warnings]]'''</font> |
| | '''| [[Cefdinir precautions|Precautions]]'''</font> |
| | '''| [[Cefdinir adverse reactions|Adverse Reactions]]'''</font> |
| | '''| [[Cefdinir overdosage|Overdosage]]'''</font> |
| | '''| [[Cefdinir clinical studies|Clinical Studies]]'''</font> |
| | '''| [[Cefdinir dosage and administration|Dosage and Administration]]'''</font> |
| | '''| [[Cefdinir compatibility reconstitution and stability|Compatibility, Reconstitution, and Stability]]'''</font> |
| | '''| [[Cefdinir directions for use|Directions For Use]]'''</font> |
| | '''| [[Cefdinir how supplied|How Supplied]]'''</font> |
| | '''| [[Cefdinir other size packages available|Other Size Packages Available]]'''</font> |
| | '''| [[Cefdinir labels and packages|Labels and Packages]]'''</font> |
| | ==FDA Package Insert==</font> |
| | ==Mechanisms of Action==</font> |
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| ==Available forms and dosage== | | ==References==</font> |
| [[Image:omnicef300mg.jpg|thumb|Omnicef 300 mg]]
| | {{Reflist|2}}</font> |
| Cefdinir is administered orally. It is available as capsules and a suspension.
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| Dosage, schedule, and duration of therapy varies according to the type of infection. For adults, the average dosage is between 300 and 600 mg per 12 or 24 hour period, for the duration of between 5 and 10 days. Average pediatric dosage is between 7 and 14 mg/kg (schedule and duration the same as adult).
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| == Notes ==
| | [[Category:Antibiotics]]</font> |
| * Marketed by [[Hikma|Hikma Pharmaceuticals PLC]] in [[MENA|MENA region]] under the brand name Omnicef®
| | [[Category:Wikinfect]]</font> |
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| =="Blood" in the Stool==
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| The pediatric version of Omnicef® can bind to iron in the digestive tract. In rare cases, this creates a discoloration of the stool to a rust or red color. Some patients may interpret this as blood in the stool, although in reality blood appears dark brown or black in the stool. A doctor's office can perform a simple [[stool guaiac test]] on the stool to confirm that it does not have blood. If you simply wait one hour, the red color will remain red, (while real blood will turn black).
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| On the other hand, if the reddish stool is accompanied by abdominal pain, weight loss, diarrhea, etc., it could be a C. difficile (clostridium difficile) infection caused by the antibiotic. This infection can occur as a result of taking an antibiotic. Talk to your pediatrician immediately to see if you should stop using the antibiotic.
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| ==References==
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| {{Reflist}}
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| ==External links==
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| *[http://www.omnicef.com Omnicef homepage]
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| {{CephalosporinAntiBiotics}}
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| [[Category:Cephalosporin antibiotics]] | |
| [[Category:Thiazoles]] | |
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| [[th:เซฟดิเนียร์]]
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