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==Overview==
==Overview==
Carcinoid syndrome was first described by Siegfried Oberndorfer, a German [[pathologist]] in 1907. Endocrine related properties of carcinoids was described by Gosset and Masson in 1914.<ref name="pmid24713679">{{cite journal| author=Tsoucalas G, Karamanou M, Androutsos G| title=The eminent German pathologist Siegfried Oberndorfer (1876-1944) and his landmark work on carcinoid tumors. | journal=Ann Gastroenterol | year= 2011 | volume= 24 | issue= 2 | pages= 98-100 | pmid=24713679 | doi= | pmc=PMC3959292 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24713679  }} </ref>
The term [[Carcinoid]] was given by Siegfried Oberndorfer, a German [[pathologist]] at the University of [[Munich]] in 1907. [[Enterochromaffin cell]], the [[cell]] of origin of [[carcinoid]] [[tumour]] had been identified as early as 1897 by N. [[Kulchitsky cells|Kulchitsky]].
 
==Historical Perspective==
==Historical Perspective==
Carcinoids were first described in 1907 by Siegfried Oberndorfer, a German [[pathologist]] at the University of Munich, who coined the term ''karzinoide'', or "carcinoma-like", to describe the unique feature of behaving like a [[benign tumor]] despite having a [[malignant]] appearance microscopically.<ref name="pmid3959292">{{cite journal| author=Swiryn S, Hueter DC| title=The electrocardiogram in esophageal impaction. | journal=JAMA | year= 1986 | volume= 255 | issue= 15 | pages= 2067-8 | pmid=3959292 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3959292  }} </ref> The recognition of their endocrine-related properties were later described by Gosset and Masson in 1914, and these tumors are now known to arise from the [[enterochromaffin]] (EC) and enterochromaffin-like (ECL) cells of the gut.<ref name="pmid24713679">{{cite journal| author=Tsoucalas G, Karamanou M, Androutsos G| title=The eminent German pathologist Siegfried Oberndorfer (1876-1944) and his landmark work on carcinoid tumors. | journal=Ann Gastroenterol | year= 2011 | volume= 24 | issue= 2 | pages= 98-100 | pmid=24713679 | doi= | pmc=PMC3959292 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24713679  }} </ref>
* Theodor Langhans (1839–1915) was the first to describe the [[histology]] of a [[carcinoid tumor]] in 1867.
* The term [[Carcinoid]] was given by Siegfried Oberndorfer, a German [[pathologist]] at the University of Munich in 1907.
* Siegfried Oberndorfer referred the [[carcinoid tumor]] as "[[benign]] [[Carcinomas|carcinomas"]] as they had distinct clinical entities and named them "karzinoide"[[Carcinoma|(carcinoma]]-like).
* Karzinoide or “[[carcinoma]]-like” describes the unique feature of behaving like a [[benign]] [[tumor]] despite resembling a [[carcinoma]] microscopically.
* Rapport and colleagues isolated and named [[serotonin]] [[5-HT|(5-HT]]), initially identified as a [[vasoconstrictor]] [[substance]] in the [[serum]].<ref name="pmid18100415">{{cite journal |vauthors=RAPPORT MM, GREEN AA, PAGE IH |title=Serum vasoconstrictor, serotonin; isolation and characterization |journal=J. Biol. Chem. |volume=176 |issue=3 |pages=1243–51 |date=December 1948 |pmid=18100415 |doi= |url=}}</ref>
*<nowiki/>[[Enterochromaffin]] [[Cell|cel]]<nowiki/>l,the [[cell]] of origin of [[carcinoid tumour]] had been identified as early as 1897 by N. Kulchitsky (1856-1925).
* In 1953, F. Lembeck <nowiki/>established that [[enterochromaffin]] [[cells]] synthesizes and secretes [[serotonin]], the major [[hormone]] responsible for [[Carcinoid Syndrome|carcinoid syndrome.]]<ref name="pmid14941051">{{cite journal |vauthors=ERSPAMER V, ASERO B |title=Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine |journal=Nature |volume=169 |issue=4306 |pages=800–1 |date=May 1952 |pmid=14941051 |doi= |url=}}</ref><ref name="pmid16882492">{{cite journal |vauthors=Sippel RS, Chen H |title=Carcinoid tumors |journal=Surg. Oncol. Clin. N. Am. |volume=15 |issue=3 |pages=463–78 |date=July 2006 |pmid=16882492 |doi=10.1016/j.soc.2006.05.002 |url=}}</ref>


==References==
==References==
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==References==
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[[Category:Disease]]
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Latest revision as of 20:55, 30 April 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]

Overview

The term Carcinoid was given by Siegfried Oberndorfer, a German pathologist at the University of Munich in 1907. Enterochromaffin cell, the cell of origin of carcinoid tumour had been identified as early as 1897 by N. Kulchitsky.

Historical Perspective

References

  1. RAPPORT MM, GREEN AA, PAGE IH (December 1948). "Serum vasoconstrictor, serotonin; isolation and characterization". J. Biol. Chem. 176 (3): 1243–51. PMID 18100415.
  2. ERSPAMER V, ASERO B (May 1952). "Identification of enteramine, the specific hormone of the enterochromaffin cell system, as 5-hydroxytryptamine". Nature. 169 (4306): 800–1. PMID 14941051.
  3. Sippel RS, Chen H (July 2006). "Carcinoid tumors". Surg. Oncol. Clin. N. Am. 15 (3): 463–78. doi:10.1016/j.soc.2006.05.002. PMID 16882492.

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References

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