Basal cell carcinoma causes: Difference between revisions

Jump to navigation Jump to search
No edit summary
(Mahshid)
Line 53: Line 53:
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Pathology]]
[[Category:Pathology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Dermatology]]
[[Category:Surgery]]

Revision as of 02:27, 6 November 2017

Basal cell carcinoma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Basal Cell Carcinoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

CT scan

MRI

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Basal cell carcinoma causes On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Basal cell carcinoma causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Basal cell carcinoma causes

CDC on Basal cell carcinoma causes

Basal cell carcinoma causes in the news

Blogs on Basal cell carcinoma causes

Directions to Hospitals Treating Basal cell carcinoma

Risk calculators and risk factors for Basal cell carcinoma causes

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saarah T. Alkhairy, M.D.

Overview

Basal cell carcinoma may be caused by genetic mutations that are associated with genetic syndromes or by environmental causes, such as chronic sunlight exposure.

Basal Cell Carcinoma Causes

Although the exact cause is unknown, there are some environmental and genetic factors that may predispose to basal cell carcinoma.

The following table summarizes the causes of basal cell carcinoma (BCC):

Cause Description
Radiation exposure Sunlight (UV light), tanning beds, and x-rays exposure are associated with basal cell carcinoma formation[1]
Gene mutations TP53 gene mutations and the inappropriate activation of the hedgehog signaling pathway (loss-of-function mutations in tumor-suppressor protein patched homologue 1 (PTCH1) and gain-of-function mutations in sonic hedgehog (SHH), smoothened (SMO), and Gli) are associated with basal cell carcinoma[2]
Xeroderma pigmentosum This an autosomal recessive disorder; it results in the inability to repair ultraviolet-induced DNA damage; pigmentary changes are seen early in life, followed by the development of basal cell carcinoma, squamous cell carcinoma, and malignant melanoma; other features include corneal opacities, eventual blindness, and neurological deficits[3]
Epidermodysplastic verruciformis Epidermodysplastic verruciformis is an autosomal recessive disorder characterized by the development of basal cell carcinoma and squamous cell carcinoma from warts (human papillomavirus infection)[4]
Nevoid basal cell carcinoma syndrome This is an autosomal dominant disorder that can result in basal cell carcinomas, multiple odontogenic keratocysts, palmoplantar pitting, intracranial calcification, and rib anomalies[5]
Bazex Syndrome The features of Bazex syndrome include follicular atrophoderma, multiple basal cell carcinomas, and local anhidrosis[6]
Rombo syndrome Rombo syndrome is an autosomal dominant condition distinguished by basal cell carcinoma and atrophoderma vermiculatum, trichoepitheliomas, hypotrichosis milia, and peripheral vasodilation with cyanosis[7]

References

  1. Lim JL, Stern RS (2005). "High levels of ultraviolet B exposure increase the risk of non-melanoma skin cancer in psoralen and ultraviolet A-treated patients". J Invest Dermatol. 124 (3): 505–13. doi:10.1111/j.0022-202X.2005.23618.x. PMID 15737190.
  2. de Zwaan SE, Haass NK (2010). "Genetics of basal cell carcinoma". Australas J Dermatol. 51 (2): 81–92, quiz 93-4. doi:10.1111/j.1440-0960.2009.00579.x. PMID 20546211.
  3. Lear, J. T.; Smith, A. G. (1997). "Basal cell carcinoma". Postgraduate Medical Journal. 73 (863): 538–542. doi:10.1136/pgmj.73.863.538. ISSN 0032-5473.
  4. Harwood CA, Surentheran T, Sasieni P, Proby CM, Bordea C, Leigh IM; et al. (2004). "Increased risk of skin cancer associated with the presence of epidermodysplasia verruciformis human papillomavirus types in normal skin". Br J Dermatol. 150 (5): 949–57. doi:10.1111/j.1365-2133.2004.05847.x. PMID 15149508.
  5. Cohen MM (1999). "Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses". Int J Oral Maxillofac Surg. 28 (3): 216–23. PMID 10355946.
  6. Centers for Disease Control and Prevention (CDC). Sunburn prevalence among adults--United States, 1999, 2003, and 2004. MMWR Morb Mortal Wkly Rep. 2007 Jun 1. 56(21):524-8
  7. Michaëlsson G, Olsson E, Westermark P (1981). "The Rombo syndrome: a familial disorder with vermiculate atrophoderma, milia, hypotrichosis, trichoepitheliomas, basal cell carcinomas and peripheral vasodilation with cyanosis". Acta Derm Venereol. 61 (6): 497–503. PMID 6177160.