Autoimmune polyendocrine syndrome differential diagnosis: Difference between revisions

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==Overview==
==Overview==
[Disease name] must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].
Autoimmune polyendocrine syndrome must be differentiated from other conditions which lead to ployendoicrine disorders such as . APS commonly involves disorders such asThe following table characterises the difference among various subtypes of APS.
 
OR
 
[Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].


==Differentiating X from other Diseases==
==Differentiating X from other Diseases==

Revision as of 19:36, 5 October 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

Autoimmune polyendocrine syndrome must be differentiated from other conditions which lead to ployendoicrine disorders such as . APS commonly involves disorders such asThe following table characterises the difference among various subtypes of APS.

Differentiating X from other Diseases

  • Autoimmune polyendocrine syndrome must be differentiated among its subtype. The following table characterises the difference among various subtypes of APS.
Characterstic Autoimmune

polyendocrine syndrome

type 1

Autoimmune

polyendocrine syndrome

type 2

Autoimmune

polyendocrine syndrome

type 3

Inheritance Autosomal recessive Autosomal dominant X-linked
Gene(s) involved AIRE (transcription factor) Polygenic FOXP3 (transcription factor)
HLA genptype HLA-D3 and HLA-D4 HLA-DQ2 and HLA-DQ8; HLA-DRB1*0404 None
Pathogenesis Autoreactive T cells escape

negative selection

Unknown Defective T cell regulation leading to T cell

activation and proliferation

Age of onset Infancy Infancy and adulthood Neonatal
Clinical features

(most common)

Candidiasis

Hypoparathyroidism

Addison’s disease

Addison’s disease

Diabetes mellitus type 1A

Autoimmune thyroiditis

Neonatal diabetes

Malabsorption

Diabetes 18% 20-50% >60%
Other manifestations Hepatitis, malabsorption, asplenism,

oophoritis, alopecia and vitiligo

Autoimmune gastritis, celiac disease,

oophoritis and vitiligo

Autoimmune thyroiditis, haemolytic anemia,

thrombocytopenia and lymphadenopathy

Gender predisposition Equal in males and females Females>males Males (X-linked)
Immunodeficiency Immunodeficienct No defined immunodeficiency Immunodeficienct
Prevalence Rare Common Very rare

Autoimmune polyendocrine syndrome [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as [differential dx1], [differential dx2], and [differential dx3].

  • [Disease name] must be differentiated from [[differential dx1], [differential dx2], and [differential dx3].
  • As [disease name] manifests in a variety of clinical forms, differentiation must be established in accordance with the particular subtype. [Subtype name 1] must be differentiated from other diseases that cause [clinical feature 1], such as [differential dx1] and [differential dx2]. In contrast, [subtype name 2] must be differentiated from other diseases that cause [clinical feature 2], such as [differential dx3] and [differential dx4].

Preferred Table

Diseases Laboratory Findings Physical Examination History and Symptoms Other Findings
Lab Test 1 Lab Test 2 Lab Test 3 Lab Test 4 Physical Finding 1 Physical Finding 2 Physical Finding 3 Physical Finding 4 Finding 1 Finding 2 Finding 3 Finding 4
Differential Diagnosis 1 +
Differential Diagnosis 2 -
Differential Diagnosis 3
Differential Diagnosis 4
Differential Diagnosis 5

References

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