Antiphospholipid syndrome primary prevention: Difference between revisions

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Patients with systemic lupus erythematosus and lupus anticoagulant and/or persistently positive anticardiolipin
Asymptomatic carriers of antiphospholipid antibodies
High-risk situations (surgery, post partum, long-lasting immobilisation)
Primary thromboprophylaxis
Hydroxychloroquine and consider low-dose aspirin
No therapy or low-dose aspirin
Adequate thrombophylaxis
Patients with obstetric antiphospholipid syndrome
Low-dose aspirin or no therapy
All patients with antiphospholipid antibodies
Strict control of vascular risk factors
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 16:15, 12 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Feham Tariq, MD [2]

Overview

Primary Prevention

The primary prevention of antiphospholipid syndrome is as follows:[1][2][3]

  • Anticoagulation in patients with risk factors for arterial and venous thrombosis.
  • Minimizing the contribution of reversible risk factors for recurrent thrombosis.
  • A daily low dose of aspirin for primary thrombosis prevention in asymptomatic individuals with persistent antiphospholipid antibodies.
  • Use of statins in patients with hyperlipidemia.
Primary thromboprophylaxis
Patients with systemic lupus erythematosus and lupus anticoagulant and/or persistently positive anticardiolipin Hydroxychloroquine and consider low-dose aspirin
Patients with obstetric antiphospholipid syndrome Low-dose aspirin or no therapy
Asymptomatic carriers of antiphospholipid antibodies No therapy or low dose aspirin
All patients with antiphospholipid antibodies Strict control of vascular risk factors
High-risk situations (surgery, post partum, long-lasting immobilisation) Adequate thromboprophylaxis

References

  1. Nalli C, Andreoli L, Casu C, Tincani A (2014). "Management of recurrent thrombosis in antiphospholipid syndrome". Curr Rheumatol Rep. 16 (3): 405. doi:10.1007/s11926-013-0405-4. PMID 24449256.
  2. Erkan D, Lockshin MD (2004). "How much warfarin is enough in APS related thrombosis?". Thromb Res. 114 (5–6): 435–42. doi:10.1016/j.thromres.2004.06.010. PMID 15507275.
  3. Khamashta MA, Cuadrado MJ, Mujic F, Taub NA, Hunt BJ, Hughes GR (1995). "The management of thrombosis in the antiphospholipid-antibody syndrome". N Engl J Med. 332 (15): 993–7. doi:10.1056/NEJM199504133321504. PMID 7885428.

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